2-(3-hydroxy-4-methoxyphenyl)-8-methyl-3,4-dihydro-2H-chromen-7-ol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-(3-hydroxy-4-methoxyphenyl)-8-methyl-3,4-dihydro-2H-chromen-7-ol
• 化学式: C₁₇H₁₈O₄
• 分子量: 286.32
• InChiKey: XVHKLOFEZNFSRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING SWEET TASTE
  申请人：Chromocell Corporation

  公开号：EP3188728A1

  公开（公告）日：2017-07-12
• [EN] THERAPEUTIC RELEASE AGENTS<br/>[FR] AGENTS DE LIBÉRATION THÉRAPEUTIQUES
  申请人：ORGANON NV

  公开号：WO2008100977A2

  公开（公告）日：2008-08-21

  [EN] Pharmacological inhibition of fatty acid amide hydrolase (FAAH) activity leads to increased levels of fatty acid amides. Esters of alkylcarbamic acids are disclosed that are inhibitors of FAAH activity. Compounds disclosed herein inhibit FAAH activity. Described herein are processes for the preparation of esters of alkylcarbamic acid compounds, compositions that include them, and methods of use thereof.
  [FR] L'inhibition pharmacologique de l'activité de l'amide hydrolase d'acides gras (FAAH) entraîne une augmentation des taux d'amides d'acides gras. L'invention concerne des esters d'acides alkylcarbamiques qui constituent des inhibiteurs de l'activité de la FAAH. Les composés décrits inhibent l'activité de la FAAH. L'invention concerne aussi des procédés de préparation d'esters de composés d'acides alkylcarbamiques, des compositions renfermant ceux-ci et des procédés d'utilisation de celles-ci.
• [EN] COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING SWEET TASTE<br/>[FR] COMPOSÉS, COMPOSITIONS ET PROCÉDÉS PERMETTANT DE MODULER LE GOÛT DE SUCRÉ
  申请人：CHROMOCELL CORP

  公开号：WO2016036980A1

  公开（公告）日：2016-03-10

  The present invention provides edible compositions comprising a sweet taste modulator or bitter taste blocker of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of sugar in a food product, methods of reducing the caloric intake in a diet, and methods of enhancing sweet taste or blocking a bitter taste in a food product.
• [EN] METHODS, COMPOUNDS, AND COMPOSITIONS, FOR MODULATING SWEET TASTE<br/>[FR] PROCÉDÉS, COMPOSÉS, ET COMPOSITIONS POUR MODULER UN GOÛT SUCRÉ
  申请人：CHROMOCELL CORP

  公开号：WO2017189778A1

  公开（公告）日：2017-11-02

  The present invention provides methods of improving the taste of sweeteners and sweet taste modulator, comprising esterifying one or more hydroxyl groups of such sweetener and sweet taste modulator, edible compositions comprising such improved sweeteners and improved sweet taste modulator, food and beverage products comprising such edible composition, and methods of preparing such food products.