3-ethyl-4-piperidineacetic acid ethyl ester | 408507-84-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-ethyl-4-piperidineacetic acid ethyl ester
• 英文别名: (3-ethyl-piperidin-4-yl)-acetic acid ethyl ester；(3-ethyl-[4]piperidyl)-acetic acid ethyl ester；(3-Aethyl-[4]piperidyl)-essigsaeure-aethylester；Ethyl 3-ethyl-4-piperidineacetate；ethyl 2-(3-ethylpiperidin-4-yl)acetate
• CAS: 408507-84-6
• 化学式: C₁₁H₂₁NO₂
• 分子量: 199.293
• InChiKey: ZMYQHFQMRLPPRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-ethyl-4-piperidineacetic acid ethyl ester 、 2-[bis(4-fluorophenyl)methoxy]ethyl chloride 在 potassium carbonate 、 sodium iodide 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以21%的产率得到
  参考文献：
  名称：

  New N-(benzhydryloxyalkyl)-4-(carboxy/carbamoylmethyl) piperidine derivatives with antidepressant activity

  摘要：

  Several benzhydryloxylalkylpiperidine derivatives were prepared with the aim of obtaining new antidepressant compounds. The influence of the length of the aliphatic chain and of aromatic and piperidine ring substitutions was studied. The pharmacological activity of compounds was investigated in vivo by means of a screening comprising four pharmacological tests: antagonism of reserpine and apomorphine hypothermia; increase of yohimbine induced mortality; and antagonism of immobility in tail suspension test. An in-depth pharmacological study was performed with the more active compounds and a binding study to serotonin (5-HT), norepinephrine (NE) and dopamine (DA) reuptake sites was performed for the preferred compounds. The most active compounds [+], [-]-cis-31, 32 and 46 exhibited an interesting psychopharmacological profile after intraperitoneal administration. This profile was confirmed by the oral route for 31 and 46. In vitro, these compounds showed a non-selective inhibition of DA, NE and 5-HT uptake.

  DOI：

  10.1016/s0223-5234(97)83972-4
• 作为产物：
  描述：

  ethyl 2-(1-benzyl-3-ethylpiperidin-4-ylidene)acetate 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 生成 3-ethyl-4-piperidineacetic acid ethyl ester
  参考文献：
  名称：

  Bonjoch, Josep; Linares, Ana; Guardia, Manel, Heterocycles, 1987, vol. 26, # 8, p. 2165 - 2174

  摘要：

  DOI：

文献信息

• Skraup, Monatshefte fur Chemie, 1895, vol. 16, p. 175
  作者：Skraup

  DOI：——

  日期：——
• Rabe; Naumann, Justus Liebigs Annalen der Chemie, 1909, vol. 365, p. 363
  作者：Rabe、Naumann

  DOI：——

  日期：——
• Novel quinoline derivatives, pharmaceutical compositions containing such compounds, and method for the preparation of these compounds
  申请人：ACF CHEMIEFARMA NV

  公开号：EP0035820B1

  公开（公告）日：1984-10-10
• US3957800A
  申请人：——

  公开号：US3957800A

  公开（公告）日：1976-05-18
• US3959294A
  申请人：——

  公开号：US3959294A

  公开（公告）日：1976-05-25