4-(1-methoxy-pentylidene)-3-(4-methoxy-phenyl)-5-methyl-3-dihydro-furan-2-one | 1186524-47-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(1-methoxy-pentylidene)-3-(4-methoxy-phenyl)-5-methyl-3-dihydro-furan-2-one
• CAS: 1186524-47-9
• 化学式: C₁₈H₂₄O₄
• 分子量: 304.386
• InChiKey: PUYRQNOEBKZZOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.81
• 重原子数：
  22.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  44.76
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  4-(1-methoxy-pentylidene)-3-(4-methoxy-phenyl)-5-methyl-3-dihydro-furan-2-one 在 甲烷磺酸 作用下， 以 四氢呋喃 、 水 为溶剂， 以83%的产率得到3-(4-methoxy-phenyl)-5-methyl-4-pentanoyl-5H-furan-2-one
  参考文献：
  名称：

  Reaction of substituted alkynols with alkoxycarbene complexes of chromium: a facile synthesis of substituted α,β-unsaturated-γ-butyrolactones

  摘要：

  Substituted alpha,beta-unsaturated-gamma-butyrolactones, were synthesized from Fischer chromium carbenes and substituted alkynols in a two-step sequence. This method demonstrates a novel and mild route for the synthesis of this class of molecules. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.06.076
• 作为产物：
  描述：

  pentacarbonyl(methoxyl)(n-butyl)carbene chromium(0) 、 4-(4-methoxyphenyl)but-3-yn-2-ol 以48%的产率得到4-(1-methoxy-pentylidene)-3-(4-methoxy-phenyl)-5-methyl-3-dihydro-furan-2-one
  参考文献：
  名称：

  Reaction of substituted alkynols with alkoxycarbene complexes of chromium: a facile synthesis of substituted α,β-unsaturated-γ-butyrolactones

  摘要：

  Substituted alpha,beta-unsaturated-gamma-butyrolactones, were synthesized from Fischer chromium carbenes and substituted alkynols in a two-step sequence. This method demonstrates a novel and mild route for the synthesis of this class of molecules. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.06.076

文献信息

• Reaction of substituted alkynols with alkoxycarbene complexes of chromium: a facile synthesis of substituted α,β-unsaturated-γ-butyrolactones
  作者：Subhabrata Sen、Kailaskumar Borate、Parag Kulkarni、Nandini R. Pai

  DOI：10.1016/j.tetlet.2009.06.076

  日期：2009.9

  Substituted alpha,beta-unsaturated-gamma-butyrolactones, were synthesized from Fischer chromium carbenes and substituted alkynols in a two-step sequence. This method demonstrates a novel and mild route for the synthesis of this class of molecules. (C) 2009 Elsevier Ltd. All rights reserved.