5-(1-羟基乙基)-4-甲基噻唑 | 45657-12-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 5-(1-羟基乙基)-4-甲基噻唑
• 英文名称: 4-methyl-5-thiazolyl-ethanol
• 英文别名: 1-(4-methyl-thiazol-5-yl)-ethanol；1-(4-Methyl-thiazol-5-yl)-aethanol；4-methyl-5-hydroxyethylthiazole；4-methyl-5-thiazole ethanol；4-methyl-5-thiazolylethanol；5-<1-Hydroxy-aethyl>-4-methyl-thiazol；5-(1-Hydroxyethyl)-4-methylthiazole；1-(4-methyl-1,3-thiazol-5-yl)ethanol
• CAS: 45657-12-3
• 化学式: C₆H₉NOS
• 分子量: 143.21
• InChiKey: NKLZSLYZLRJWOY-UHFFFAOYSA-N

物化性质

• 沸点：
  146 °C(Press: 18 Torr)
• 密度：
  1.172 g/cm3(Temp: 25 °C)
• LogP：
  0.064 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  61.4
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2934100090

反应信息

• 作为反应物：
  描述：

  5-(1-羟基乙基)-4-甲基噻唑 、 tert-Butyl 4-{3-[2-(3-hydroxyphenoxy)ethoxy]-2-pyrazinyl}-1-piperazinecarboxylate 以57 mg (51%)的产率得到2-(2-{3-[2-(4-Methyl-1,3-thiazol-5-yl)ethoxy]phenoxy}ethoxy)-3-(1-piperazinyl)pyrazine, Trifluoroacetate
  参考文献：
  名称：

  Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases

  摘要：

  通式（I）的化合物： 其中变量如规范中定义的那样，对于预防或治疗人类或动物中与血清素相关，特别是5-HT2受体相关的疾病是有用的，特别是与5-HT2c受体相关的疾病，尤其是与进食障碍、记忆障碍、精神分裂症、情绪障碍、焦虑障碍、疼痛、性功能障碍和尿液障碍等疾病相关的疾病。

  公开号：

  US06465467B1
• 作为产物：
  描述：

  4-甲基-5-乙酰基噻唑 在 aluminum isopropoxide 、 异丙醇 作用下， 生成 5-(1-羟基乙基)-4-甲基噻唑
  参考文献：
  名称：

  Thiamin Analogs. II. 4-Methylthiazole Analogs^1,2

  摘要：

  DOI：

  10.1021/ja01219a012

文献信息

• THIAZOLIDINONE COMPOUNDS AND USE THEREOF
  申请人：National Health Research Institutes

  公开号：US20170253569A1

  公开（公告）日：2017-09-07

  A pharmaceutical composition containing a compound of Formula (I) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. Further disclosed are two sets of thiazolidinone compounds of formula (I): (i) compounds each having an enantiomeric excess greater than 90% and (ii) compounds each being substituted with deuterium.

  一种含有化合物（I）的药物组合物，用于治疗与阿片受体相关的疾病。还公开了一种使用这种化合物治疗阿片受体相关疾病的方法。进一步公开了两组式（I）的噻唑烷酮化合物：（i）每种化合物的对映体过量大于90%；（ii）每种化合物被氘取代。
• 1H-pyrrole-2,4-dicarbonyl-derivatives and their use as flavoring agents
  申请人：IMAX Discovery GmbH

  公开号：EP2832233A1

  公开（公告）日：2015-02-04

  The present invention primarily relates to 1H-pyrrole-2,4-dicarbonyl-derivatives of Formula (I) wherein R1, R2, R3, Z. Z' and J are as defined in the description, to mixtures thereof and to the use thereof as flavoring agents. The compounds in accordance with the present invention are suitable for producing, imparting, or intensifying an umami flavor. The invention further relates to flavoring mixtures, compositions for oral consumption as well as ready-to-eat, ready-to-use and semifinished products, comprising an effective amount of the compound of Formula (I) or of a mixture of compounds of Formula (I) and to specific methods for producing, imparting, modifying and/or intensifying specific flavor impressions.

  本发明主要涉及式(I)的1H-吡咯-2,4-二羰基衍生物，其中R1、R2、R3、Z、Z'和J按描述定义，及其混合物，以及用作调味剂的使用。根据本发明的化合物适用于生产、赋予或增强鲜味。本发明进一步涉及包含式(I)化合物或式(I)化合物混合物的有效量的调味混合物、口腔消费的组成物以及即食、即用和半成品，以及用于生产、赋予、改变和/或增强特定风味印象的特定方法。
• Imidazo[1,2-a]pyridine-ylmethyl-derivatives and their use as flavoring agents
  申请人：IMAX Discovery GmbH

  公开号：EP2832234A1

  公开（公告）日：2015-02-04

  The present invention primarily relates to imidazo[1,2-a]pyridine-ylmethyl-derivatives of Formula (I) wherein R1, R2, X, W e J are as defined in the description, to mixtures thereof and to the use thereof as flavoring agents. The compounds in accordance with the present invention are suitable for producing, imparting, or intensifying an umami flavor. The invention further relates to flavoring mixtures, compositions for oral consumption as well as ready-to-eat, ready-to-use and semifinished products, comprising an effective amount of the compound of Formula (I) and to specific methods for producing, imparting, modifying and/or intensifying specific flavor impressions.

  本发明主要涉及式(I)的咪唑[1,2-a]吡啶基甲基衍生物，其中R1、R2、X、W和J如描述中定义，以及涉及它们的混合物和使用它们作为调味剂。根据本发明的化合物适合于产生、赋予或增强鲜味。本发明进一步涉及调味混合物、口腔摄入的配方以及包含有效量的式(I)化合物的即食、即用和半成品，以及用于生产、赋予、改变和/或增强特定风味印象的特定方法。
• Formamido and carboxyamido compounds which can be retained in brain
  申请人：Drug Delivery System Institute, Ltd.

  公开号：US05580904A1

  公开（公告）日：1996-12-03

  According to the present invention, a novel compound group which can pass through blood-brain barrier (BBB) with carrying a drug thereon and stay within brain to release the drug and a well-known compound group having the properties described above are provided. The compound represented by the general formula ##STR1## wherein, R.sup.1 represents C.sub.1-6 alkyl which may be substituted by a group selected from hydroxyl, carboxyl, amino group which may be substituted by C.sub.1-6 alkyl, and a five- to seven-membered saturated heterocyclic ring, R.sup.2 represents hydrogen or C.sub.1-6 alkyl, R.sup.3 represents hydrogen or C.sub.1-6 alkyl which may be substituted by hydroxyl, R.sup.4 represents hydrogen or C.sub.1-6 alkyl, R.sup.5 represents an amino acid residue, or --S--R.sup.6 or --CO--R.sup.6 wherein R.sup.6 represents C.sub.1-14 alkyl which may be substituted by a five- to seven-membered saturated ring; C.sub.2-6 alkenyl; aryl; or a five- to seven-membered saturated ring; or the group represented by the general formula (IVa): ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the same meanings as defined above, and .multidot..multidot..multidot..multidot..multidot..multidot..multidot..mult idot..multidot. represents a single bond or a double bond provided that at least one of R.sup.1, R.sup.3 and R.sup.5 contains hydroxyl, carboxyl or amino, and a salt thereof.

  根据本发明，提供了一种新的化合物组，该化合物组可以携带药物穿过血脑屏障（BBB），停留在大脑内释放药物，并提供了具有上述特性的众所周知的化合物组。所述化合物由通式##STR1##所表示，其中，R.sup.1代表可由羟基、羧基、氨基（可由C.sub.1-6烷基取代）和五至七元饱和杂环环组成的基团取代的C.sub.1-6烷基，R.sup.2代表氢或C.sub.1-6烷基，R.sup.3代表氢或可由羟基取代的C.sub.1-6烷基，R.sup.4代表氢或C.sub.1-6烷基，R.sup.5代表氨基酸残基，或--S--R.sup.6或--CO--R.sup.6，其中R.sup.6代表可由五至七元饱和环取代的C.sub.1-14烷基；C.sub.2-6烯基；芳基；或五至七元饱和环；或通式（IVa）所表示的基团：##STR2##其中R.sup.1、R.sup.2、R.sup.3和R.sup.4具有如上定义的相同含义，且.multidot..multidot..multidot..multidot..multidot..multidot..multidot..mult idot..multidot.代表单键或双键，前提是R.sup.1、R.sup.3和R.sup.5中至少有一个含有羟基、羧基或氨基，以及其盐。
• Pyrimidinone Derivatives as Antimalarial Agents
  申请人：SANOFI

  公开号：US20150183804A1

  公开（公告）日：2015-07-02

  The invention relates to novel pyrimidinone-based heterocyclic compounds which are parasite growth inhibitors, having the general formula (I) in which Y is a morpholine chosen from three bridged morpholines, L is a bond or a linker, n=0 or 1 and R 2 is a methyl group when n=0 and a hydrogen atom when n=1. Process for the preparation thereof and therapeutic use thereof.

  这项发明涉及一种新型的嘧啶酮基杂环化合物，这些化合物是寄生虫生长抑制剂，其一般式为（I），其中Y是从三种桥联吗啉中选择的吗啉，L是键或连接物，n=0或1，当n=0时R2是甲基基团，当n=1时是氢原子。其制备方法和治疗用途。