S-(N-Ethylsuccinimido)cystein

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: S-(N-Ethylsuccinimido)cystein
• 英文别名: α-(1-Amino-1-carboxy-ethylmercapto)-N-ethyl-succinimid；S-(1-ethyl-2,5-dioxo-pyrrolidin-3-yl)-cysteine；2-Amino-3-(1-ethyl-2,5-dioxopyrrolidin-3-yl)sulfanylpropanoic acid；2-amino-3-(1-ethyl-2,5-dioxopyrrolidin-3-yl)sulfanylpropanoic acid
• 化学式: C₉H₁₄N₂O₄S
• 分子量: 246.287
• InChiKey: RPPKKMNJEXCQNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  126
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  S-(N-Ethylsuccinimido)cystein 在 氢氧化钾 作用下， 反应 36.0h， 生成 3-Oxo-2--1,4-thiazancarbonsaeure-(5)
  参考文献：
  名称：

  Some Reactions of N-Ethylmaleimide¹

  摘要：

  The reactions of N-ethylmaleimide (NEM) with the amino group of peptides, with imidazole and with cysteine have been investigated. With the first two classes of compound, an IN-acylation reaction appears to occur, followed in the case of imidazole by a catalytic polymerization of NEM. With cysteine, reaction proceeds through addition of the thiol to the olefinic bond of NEM; in alkaline solution, the cysteine adduct undergoes all intramolecular transamidation reaction to form a thiazane derivative.

  DOI：

  10.1021/ja01502a039
• 作为产物：
  描述：

  N-乙基马来酰亚胺 、 DL-半胱氨酸 在 甲酸铵 作用下， 以 水 为溶剂， 生成 S-(N-Ethylsuccinimido)cystein
  参考文献：
  名称：

  MISER chromatography (multiple injections in a single experimental run): the chromatogram is the graph

  摘要：

  An experimental approach for rapid analysis and convenient interpretation of multiparallel experiments is described. Conventional approaches use a series of individual chromatographic runs to produce integrated peak area data, which are stored in individual data files, then transferred to a spreadsheet program and graphed to allow interpretation of experimental results. A simpler and more direct approach utilizes multiple injections within a single chromatographic run to produce a continuous trace of chromatograms, which can often provide a direct visual readout of experimental outcome without the need for peak integration, data transfer, or graphing. In this approach, the chromatogram itself serves as the graph whereby the outcome of the multiparallel experiment can be discerned. The utility of the technique is greatly enhanced by the use of compound-specific detection technologies such as mass spectrometry or chiroptical spectroscopy, and can benefit from experimental designs that facilitate the direct interpretation of results. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.05.029

文献信息

• METHOD FOR SELECTIVE DETECTION AND ESTIMATION OF HISTIDINE AND CYSTEIN
  申请人：Council of Scientific and Industrial Research

  公开号：US20170240568A1

  公开（公告）日：2017-08-24

  The Invention relates to a novel receptor molecule for estimation of amino acids based on florescence enhancements. Particularly, the invention relates to a novel Cu (II)-complex as a turn-on luminescence probe for selective detection of cysteine and histidine in pure aqueous environment and in biological sample as well as for detection of cyanide ions among various anions under physiological conditions.
• [EN] METHOD FOR PRODUCING DERIVATIVE OF ORGANIC SUBSTANCE AND METHOD FOR ANALYZING SAMPLE CONTAINING ORGANIC SUBSTANCE<br/>[FR] PROCÉDÉ DE PRODUCTION D'UN DÉRIVÉ D'UNE SUBSTANCE ORGANIQUE ET PROCÉDÉ D'ANALYSE D'UN ÉCHANTILLON CONTENANT UNE SUBSTANCE ORGANIQUE<br/>[JA] 有機物質の誘導体の製造方法、及び有機物質を含む試料の分析方法
  申请人：AJINOMOTO KK

  公开号：WO2021060517A1

  公开（公告）日：2021-04-01

  スルファニル、セラニル、及びスルフィノからなる群より選択される１種以上の基を含む有機物質の誘導体の新規な製造方法を提供する。スルファニル、セラニル、及びスルフィノからなる群より選択される１種以上の基を含む有機物質を、オレフィン化合物と酸性条件下で反応させて、前記有機物質の誘導体を得ることを含み、ここで、前記オレフィン化合物は、少なくとも２個の電子求引基（ただし、ハロゲン原子を除く。）を有するエチレン構造を含む、有機物質の誘導体の製造方法。
• Some Reactions of N-Ethylmaleimide¹
  作者：Derek G. Smyth、Atsuo Nagamatsu、Joseph S. Fruton

  DOI：10.1021/ja01502a039

  日期：1960.9

  The reactions of N-ethylmaleimide (NEM) with the amino group of peptides, with imidazole and with cysteine have been investigated. With the first two classes of compound, an IN-acylation reaction appears to occur, followed in the case of imidazole by a catalytic polymerization of NEM. With cysteine, reaction proceeds through addition of the thiol to the olefinic bond of NEM; in alkaline solution, the cysteine adduct undergoes all intramolecular transamidation reaction to form a thiazane derivative.
• MISER chromatography (multiple injections in a single experimental run): the chromatogram is the graph
  作者：Christopher J. Welch、Xiaoyi Gong、Wes Schafer、Edwin C. Pratt、Tanja Brkovic、Zainab Pirzada、James F. Cuff、Birgit Kosjek

  DOI：10.1016/j.tetasy.2010.05.029

  日期：2010.7

  An experimental approach for rapid analysis and convenient interpretation of multiparallel experiments is described. Conventional approaches use a series of individual chromatographic runs to produce integrated peak area data, which are stored in individual data files, then transferred to a spreadsheet program and graphed to allow interpretation of experimental results. A simpler and more direct approach utilizes multiple injections within a single chromatographic run to produce a continuous trace of chromatograms, which can often provide a direct visual readout of experimental outcome without the need for peak integration, data transfer, or graphing. In this approach, the chromatogram itself serves as the graph whereby the outcome of the multiparallel experiment can be discerned. The utility of the technique is greatly enhanced by the use of compound-specific detection technologies such as mass spectrometry or chiroptical spectroscopy, and can benefit from experimental designs that facilitate the direct interpretation of results. (C) 2010 Elsevier Ltd. All rights reserved.