3-tert-butoxycarbonyl-2-(pyridin-3-yl)-4-thiazolidinecarboxylic acid | 118156-76-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-tert-butoxycarbonyl-2-(pyridin-3-yl)-4-thiazolidinecarboxylic acid
• 英文别名: N-Boc-2-(3-pyridyl)thiazolidine-4-carboxylic acid；N-tert-butoxycarbonyl-2-(pyridin-3-yl)thiazolidine-4-carboxylic acid；2-(3-pyridinyl)-3-tert-butoxycarbonyl-4-thiazolidinecarboxylic acid；N-tert-butoxycarbonyl-2-(3-pyridyl)thiazolidine-4-carboxylic acid；3-[(2-methylpropan-2-yl)oxycarbonyl]-2-pyridin-3-yl-1,3-thiazolidine-4-carboxylic acid
• CAS: 118156-76-6
• 化学式: C₁₄H₁₈N₂O₄S
• 分子量: 310.374
• InChiKey: VJESCIRMXSHLTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-tert-butoxycarbonyl-2-(pyridin-3-yl)-4-thiazolidinecarboxylic acid 以 四氢呋喃 、 甲醇 为溶剂， 生成 2-(3-pyridinyl)-3-tert-butoxycarbonylthiazolid-4-ylmethanol
  参考文献：
  名称：

  Platelet activating antagonists

  摘要：

  苯甲酰苯基衍生物的2-(3-吡啶基)-3-烷基-4-噻唑烷甲酰胺，2-(3-吡啶基)-噻唑-4-基乙酰胺，2-(3-吡啶基)-4-二硫杂环己烷甲酰胺或2-(3-吡啶基)二硫杂环己烷-4-基]脲基团是强力的PAF抑制剂，可用于治疗PAF相关疾病，包括过敏性休克、呼吸窘迫综合征、急性炎症、细胞免疫延迟、分娩、胎儿肺成熟和细胞分化。

  公开号：

  US05149704A1
• 作为产物：
  描述：

  二碳酸二叔丁酯 在 sodium hydroxide 作用下， 以 1,4-二氧六环 、 2-(3-吡啶)噻唑烷-4-羧酸 为溶剂， 以80%的产率得到3-tert-butoxycarbonyl-2-(pyridin-3-yl)-4-thiazolidinecarboxylic acid
  参考文献：
  名称：

  Platelet activating antagonists

  摘要：

  苯甲酰苯基衍生物的2-(3-吡啶基)-3-烷基-4-噻唑烷甲酰胺，2-(3-吡啶基)-噻唑-4-基乙酰胺，2-(3-吡啶基)-4-二硫杂环己烷甲酰胺或2-(3-吡啶基)二硫杂环己烷-4-基]脲基团是强力的PAF抑制剂，可用于治疗PAF相关疾病，包括过敏性休克、呼吸窘迫综合征、急性炎症、细胞免疫延迟、分娩、胎儿肺成熟和细胞分化。

  公开号：

  US05149704A1

文献信息

• Saturated heterocyclic carboxamide derivatives
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US04987132A1

  公开（公告）日：1991-01-22

  A saturated heterocyclic carboxamide derivative of the following general formula (I) and salts thereof which have platelet activating factor (PAF) antagonizing activity. ##STR1##

  以下是通用公式（I）的饱和杂环羧酰胺衍生物及其盐，具有血小板活化因子（PAF）拮抗活性。
• Benzoylphenyl pyridinylthiazolidine compounds as platelet activating
  申请人：Abbott Laboratories

  公开号：US05120751A1

  公开（公告）日：1992-06-09

  Benzoylphenyl derivatives of 2-(3-pyridinyl)-3-alkyl-4-thiazolidinecarboxamide, 2-(3-pyridinyl)-thiazolid-4-ylacetamide, 2-(3-pyridinyl)-4-dithiolanecarboxamide or 2-(3-pyridinyl)dithiolan-4-yl] urea are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including anaphylactic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.

  苯甲酰苯基衍生物2-(3-吡啶基)-3-烷基-4-噻唑烷羧酰胺，2-(3-吡啶基)-噻唑-4-乙酰胺，2-(3-吡啶基)-4-二硫杂环己羧酰胺或2-(3-吡啶基)二硫杂环己-4-基] 尿素是PAF的强效抑制剂，并且在治疗PAF相关疾病中具有用途，包括过敏性休克、呼吸窘迫综合征、急性炎症、细胞免疫延迟、分娩、胎儿肺成熟和细胞分化。
• Pyridylthiazolidine carboxamide derivatives and their intermediates and
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US04948795A1

  公开（公告）日：1990-08-14

  This invention provides pyridylthiazolidine carboxamide derivative shown by general formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein A.sup.1 is a single bond, carbonyl group or lower alkylene group which may include a carbonyl group and R.sup.1 is a heterocyclic ring which may be substituted with a lower alkyl group and further provides N-substituted piperazine derivatives useful as intermediates for preparing said compounds (I).

  本发明提供了一种由通式（I）表示的吡啶基噻唑烷羧酰胺衍生物及其药学上可接受的盐：##STR1## 其中A.sup.1是单键，羰基或较低的含有羰基的烷基，R.sup.1是杂环环，可以用较低的烷基基团取代，还提供了N-取代哌嗪衍生物，用于制备所述化合物（I）的中间体。
• N-substituted piperizine derivatives
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US05144035A1

  公开（公告）日：1992-09-01

  This invention provides pyridylthiazolidine carboxamide derivative shown by general formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein A.sup.1 is a single bond, carbonyl group or lower alkylene group which may include a carbonyl group and R.sup.1 is a heterocyclic ring which may be substituted with a lower alkyl group and further provides N-substituted piperazine derivatives useful as intermediates for preparing said compounds (I).

  该发明提供了一种由通式（I）所示的吡啶基噻唑烷羧酰胺衍生物及其药学上可接受的盐：##STR1##其中，A.sup.1是单键，羰基或较低的含有羰基的烷基，R.sup.1是杂环环，可以用较低的烷基取代，并且进一步提供了用于制备所述化合物（I）的中间体的N-取代哌嗪衍生物。
• Platelet activating factor antagonists
  申请人：Abbott Laboratories

  公开号：US05382670A1

  公开（公告）日：1995-01-17

  Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including septic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.

  在1-或3-位置被取代为(pyrid-3-yl)thiazolid-4-yl)alkyl-、(pyrid-3-yl)thiazolid-4-oyl)-、(pyrid-3-yl)dithiolan-4-yl)alkyl-或(pyrid-3-yl)dithiolan-4-oyl)-基团的吲哚化合物是PAF的有效抑制剂，并可用于治疗与PAF相关的疾病，包括脓毒症休克、呼吸窘迫综合症、急性炎症、迟发型细胞免疫、分娩、胎肺成熟和细胞分化。