S-(3-amino-3-oxopropyl)cysteine | 3958-15-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: S-(3-amino-3-oxopropyl)cysteine
• 英文别名: 2-amino-3-(2-carbamoylethylsulfanyl)propionic acid；Alanine, 3-((2-carbamoylethyl)thio)-；(2R)-2-amino-3-(3-amino-3-oxopropyl)sulfanylpropanoic acid
• CAS: 3958-15-4
• 化学式: C₆H₁₂N₂O₃S
• 分子量: 192.239
• InChiKey: UKMONNARIQAYBE-BYPYZUCNSA-N

物化性质

• 熔点：
  213-214 °C
• 沸点：
  485.6±45.0 °C(Predicted)
• 密度：
  1.363±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.9
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  132
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 海关编码：
  2930909090

反应信息

• 作为产物：
  描述：

  L-半胱氨酸盐酸盐无水物 、 丙烯酰胺 在 ammonium hydroxide 作用下， 生成 S-(3-amino-3-oxopropyl)cysteine
  参考文献：
  名称：

  Relative Nucleophilic Reactivities of Amino Groups and Mercaptide Ions in Addition Reactions with α,β-Unsaturated Compounds^1,2

  摘要：

  DOI：

  10.1021/ja01094a025

文献信息

• Intermolecular hydrogen bonded and self-assembled β-pleated sheet structures of β-sulfidocarbonyls
  作者：Sahid Hussain、Gopal Das、Mihir K. Chaudhuri

  DOI：10.1016/j.molstruc.2006.10.038

  日期：2007.6

  Abstract The three crystal structures of β-sulfidocarbonyls 1, 2 and 3 synthesized from the reaction of acryl amide with cystiene, 1,2-dithiol and 1,3-dithiols, respectively, in water catalyzed by borax, have been determined at 273 K. The characteristic features of the structures are self-assembly through intermolecular hydrogen bonding leading to infinite chains of molecules in one direction, in addition

  摘要 丙烯酰胺与胱氨酸、1,2-二硫醇和1,3-二硫醇在硼砂催化的水中反应合成的β-硫羰基1、2和3的三种晶体结构已在273 K下确定。 . 该结构的特征是通过分子间氢键自组装导致在一个方向上形成无限长的分子链，此外在垂直方向上堆叠这种分子链的层最终会产生 3D 的 β 褶皱片涉及晶格中 N-H⋯O、C-H⋯O 和 C-H⋯S 键的分子网络。
• TFPI inhibitors and methods of use
  申请人：BAXALTA GMBH

  公开号：US10201586B2

  公开（公告）日：2019-02-12

  The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. The peptides may be used to inhibit a TFPI, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, treat a blood coagulation disorder in a subject, purify TFPI, an identify a TFPI-binding compound.

  本发明提供了结合组织因子途径抑制剂（TFPI）的肽，包括TFPI抑制肽及其组合物。这些肽可用于抑制 TFPI、增强凝血因子缺乏症患者的凝血酶形成、增加患者的血凝块形成、治疗患者的血液凝固障碍、纯化 TFPI 以及鉴定 TFPI 结合化合物。
• TFPI INHIBITORS AND METHODS OF USE
  申请人：Baxalta GmbH

  公开号：EP2547355B1

  公开（公告）日：2017-01-11
• Method to limit acrylamide in heated foods
  申请人：Fluckiger Rudolf

  公开号：US20090022862A1

  公开（公告）日：2009-01-22

  The present invention provides a method for reducing the level of acrylamide in a food product, comprising: (a) applying an acrylamide reduction agent in alkaline solution onto a food material before heat treating the food material; and (b) heat treating the food material to form the finished food product, wherein due to application of the thiol agent in alkaline solution, the finished food product comprises reduced level of acrylamide compared to a product which has not been treated with the acrylamide reduction agent in alkaline solution before heating. In addition, the present invention provides a food production produced by the method of the present invention.
• US8450275B2
  申请人：——

  公开号：US8450275B2

  公开（公告）日：2013-05-28