2-(dimethylamino)ethyl imidazole-1-carboxylate | 714288-29-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(dimethylamino)ethyl imidazole-1-carboxylate
• 英文别名: 2-(dimethylamino)ethyl 1H-imidazole-1-carboxylate
• CAS: 714288-29-6
• 化学式: C₈H₁₃N₃O₂
• 分子量: 183.21
• InChiKey: QIVRJLWMGYTOFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  47.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(dimethylamino)ethyl imidazole-1-carboxylate 、 4-氨甲基苯甲酸甲酯盐酸盐 在 吡啶 作用下， 反应 7.0h， 以100%的产率得到methyl 4-(((2-(dimethylamino)ethoxy)carbonylamino)methyl)benzoate
  参考文献：
  名称：

  WO2007/118137

  摘要：

  公开号：
• 作为产物：
  描述：

  N,N-二甲基乙醇胺 、 N,N'-羰基二咪唑 以 二氯甲烷 、 乙腈 为溶剂， 生成 2-(dimethylamino)ethyl imidazole-1-carboxylate
  参考文献：
  名称：

  HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS

  摘要：

  这项发明涉及杂环化合物及其作为抗生素和/或抗生素增效剂的用途。这些化合物可能作为科利斯汀增效剂和SOS抑制剂起作用。

  公开号：

  US20160168140A1

文献信息

• [EN] PEPTIDIC THROMBIN INHIBITOR COMPOUND<br/>[FR] COMPOSE PEPTIDIQUE INHIBITEUR DE LA THROMBINE
  申请人：LG LIFE SCIENCES LTD

  公开号：WO2004002985A1

  公开（公告）日：2004-01-08

  The present invention relates to a novel thrombin inhibitor compound which has a good inhibitory effect against thrombosis and can be orally administered, a process for preparing the same, and to a composition for the therapeutic and/or prophylactic treatment of various diseases associated with thrombin inhibition mechanism, which comprises the same as an active ingredient.

  本发明涉及一种新颖的凝血酶抑制剂化合物，它对血栓具有很好的抑制作用，可以口服给药，其制备方法，以及包含该化合物作为活性成分的用于治疗和/或预防与凝血酶抑制机制相关联的各种疾病的组合物。
• SWITCHABLE MATERIALS, METHODS AND USES THEREOF
  申请人：QUEEN'S UNIVERSITY AT KINGSTON

  公开号：US20160244548A1

  公开（公告）日：2016-08-25

  The present application provides a composite material that comprises a solid and solid-supported non-polymeric switchable moiety, wherein the switchable moiety comprises a functional group that is switchable between a first form and a second form, said first form being neutral and hydrophobic, and said second form being ionized and hydrophilic. The composite material converts to, or is maintained in, said second form when the switchable moiety is exposed to CO 2 at amounts sufficient to maintain the ionized form. The composite material converts to, or is maintained in, said first form when CO 2 is removed or reduced to an amount insufficient to maintain the ionized form. CO 2 is removed or reduced by exposing the composite material to heat and/or a flushing inert gas such as N 2 , Ar, or air. Envisioned uses of these composite materials includes removing water from non-aqueous solvents, removing water vapour from gaseous mixtures, and cleaning industrial reaction vessels and/or pipelines.

  本申请提供了一种复合材料，其包括固体和固体支持的非聚合物可开关基团，其中，可开关基团包括一种功能基团，该功能基团可在第一形态和第二形态之间切换，所述第一形态为中性和疏水的，所述第二形态为离子化和亲水的。当可开关基团暴露于足以维持离子化形态的CO2量时，复合材料转化为或维持在第二形态。当CO2被去除或减少到不足以维持离子化形态时，复合材料转化为或维持在第一形态。通过将复合材料暴露于热和/或冲洗惰性气体（如N2、Ar或空气）中，可以去除或减少CO2。这些复合材料的预期用途包括从非水溶剂中去除水，从气态混合物中去除水蒸气，以及清洁工业反应器和/或管道。
• Polymer Side-Chain Degradation as a Tool to Control the Destabilization of Polyplexes
  作者：Arjen M. Funhoff、Cornelus F. van Nostrum、Adriënne P. C. A. Janssen、Marcel H. A. M. Fens、Daan J. A. Crommelin、Wim E. Hennink

  DOI：10.1023/b:pham.0000012165.68765.e6

  日期：2004.1

  Purpose. We purposed to design a cationic polymer that binds to pDNA to form polyplexes and that subsequently degrades within a few days at physiological pH and temperature, releasing the DNA in the cytosol of a cell.Methods. We synthesized a new monomer carbonic acid 2-dimethylaminoethyl ester 1-methyl-2-(2-methacryloylamino)-ethyl ester (abbreviated HPMA-DMAE) and the corresponding polymer. Hydrolysis of the carbonate ester of both the monomer and the polymer was investigated at 37degreesC. The DNA condensing properties of the pHPMA-DMAE was studied using dynamic light scattering (DLS) and zeta potential measurements. Degradation of the polyplexes at 37degreesC and pH 7.4 was monitored with DLS and gel electrophoresis. In vitro transfections were performed in COS-7 cell line.Results. pHPMA-DMAE is able to condense DNA into small particles (110 nm) with a positive zeta potential. The half-life of the polymer and monomer at 37degreesC and pH 7.4 was around 10 h whereas at pH 5, the half-life was 380 h. In line with this, due to hydrolysis of the side groups, pHPMA-DMAE-based polyplexes dramatically increased in size at 37degreesC and pH 7.4 whereas at pH 5.0, only a very small increase was observed. Interestingly, intact DNA was released from the polyplexes after 48 h at pH 7.4 whereas all DNA remained bound to the polymer at pH 5.0. Polyplexes were able to transfect cells with minimal cytotoxicity if the endosomal membrane-disrupting peptide INF-7 was added to the polyplex formulation.Conclusions. Degradation of the cationic side-chains of a polymer is a new tool for time-controlled release of DNA from polyplexes, preferably within the cytosol and/or nucleus.
• [EN] HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS<br/>[FR] UTILISATION DE COMPOSÉS HÉTÉROCYCLIQUES EN TANT QUE POTENTIALISATEURS D'ANTIBIOTIQUES
  申请人：SYNERECA PHARMACEUTICALS INC

  公开号：WO2016094730A1

  公开（公告）日：2016-06-16

  The invention relates to heterocyclic compounds and their use as antibiotics and/or as antibiotic potentiators. The compounds may act as colistin potentiators and SOS inhibitors.
• WO2023/12323
  申请人：——

  公开号：——

  公开（公告）日：——