1-<4-Pentyloxy-phenyl>-butan-3-on | 92729-59-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-<4-Pentyloxy-phenyl>-butan-3-on
• 英文别名: 4-(4-pentoxyphenyl)-2-butanone；4-(4-pentoxyphenyl)butan-2-one
• CAS: 92729-59-4
• 化学式: C₁₅H₂₂O₂
• mdl: MFCD11127578
• 分子量: 234.338
• InChiKey: WLDTXANJMFGRLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.533
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-<4-Pentyloxy-phenyl>-butan-3-on 、 氨基硫脲 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以88%的产率得到4-(4-pentyloxyphenyl)butan-2-ylidenethiosemicarbazide
  参考文献：
  名称：

  Rational design, synthesis and structure–activity relationships of 4-alkoxy- and 4-acyloxy-phenylethylenethiosemicarbazone analogues as novel tyrosinase inhibitors

  摘要：

  In continuing our program aimed to search for potent compounds as highly efficient tyrosinase inhibitors, here a series of novel 4-alkoxy- and 4-acyloxy-phenylethylenethiosemicarbazone analogues were designed, synthesized and their biological activities on mushroom tyrosinase were evaluated. Notably, most of compounds displayed remarkable tyrosinase inhibitory activities with IC50 value of lower than 1.0 mu M. Furthermore, the structure-activity relationships (SARs) were discussed and the inhibition mechanism and the inhibitory kinetics of selected compounds 7k and 8d were also investigated. Taken together, these results suggested that such compounds could serve as the promising candidates for the treatment of tyrosinase-related disorders and further development of such compounds might be of great interest. (C) 2015 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2015.01.024
• 作为产物：
  描述：

  1-溴戊烷 、 覆盆子酮 在 氢氧化钾 、 sodium hydroxide 作用下， 以 水 为溶剂， 生成 1-<4-Pentyloxy-phenyl>-butan-3-on
  参考文献：
  名称：

  Propanamine derivatives

  摘要：

  披露了具有抗凝血或抗真菌活性的替代丙胺醇。还披露了涉及替代丙胺醇的使用方法以及含有它们的药物组合物。

  公开号：

  US05135955A1

文献信息

• US5135955A
  申请人：——

  公开号：US5135955A

  公开（公告）日：1992-08-04
• Rational design, synthesis and structure–activity relationships of 4-alkoxy- and 4-acyloxy-phenylethylenethiosemicarbazone analogues as novel tyrosinase inhibitors
  作者：Ao You、Jie Zhou、Senchuan Song、Guoxun Zhu、Huacan Song、Wei Yi

  DOI：10.1016/j.bmc.2015.01.024

  日期：2015.3

  In continuing our program aimed to search for potent compounds as highly efficient tyrosinase inhibitors, here a series of novel 4-alkoxy- and 4-acyloxy-phenylethylenethiosemicarbazone analogues were designed, synthesized and their biological activities on mushroom tyrosinase were evaluated. Notably, most of compounds displayed remarkable tyrosinase inhibitory activities with IC50 value of lower than 1.0 mu M. Furthermore, the structure-activity relationships (SARs) were discussed and the inhibition mechanism and the inhibitory kinetics of selected compounds 7k and 8d were also investigated. Taken together, these results suggested that such compounds could serve as the promising candidates for the treatment of tyrosinase-related disorders and further development of such compounds might be of great interest. (C) 2015 Published by Elsevier Ltd.
• Propanamine derivatives
  申请人：Eli Lilly and Company

  公开号：US05135955A1

  公开（公告）日：1992-08-04

  Substituted propanamines having anticoagulant or antifungal activity are disclosed. Also disclosed are methods of use involving the substituted propanamines as well as pharmaceutical compositions containing them.

  披露了具有抗凝血或抗真菌活性的替代丙胺醇。还披露了涉及替代丙胺醇的使用方法以及含有它们的药物组合物。