5-Guanidino-3-(3-amino-phenyl)-1,2,4-oxadiazole | 88541-02-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-Guanidino-3-(3-amino-phenyl)-1,2,4-oxadiazole
• 英文别名: N''-[3-(3-Aminophenyl)-1,2,4-oxadiazol-5-yl]guanidine；2-[3-(3-aminophenyl)-1,2,4-oxadiazol-5-yl]guanidine
• CAS: 88541-02-0
• 化学式: C₉H₁₀N₆O
• 分子量: 218.218
• InChiKey: LHJVRBUCOWFZKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  129
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Guanidino heterocyclicphenylamidines, processes for their preparation and their pharmaceutical use
  申请人：ISTITUTO DE ANGELI S.p.A.

  公开号：EP0089730A2

  公开（公告）日：1983-09-28

  The object of the present invention are new pharmacologically active substituted guanidino heterocyclicphenylami- dines of the following formula in which R, R, and R2 which may be the same or different, each represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, R3 represents a linear or branched alkyl group containing optionally heteroatoms such as oxygen, sulfur or nitrogen atom, a linear or branched alkenyl group, an alkynyl group, a cyano group, a cycloalkyl or cycloaliphatic alkyl group, a bicyclic group, an aryl group, a heterocyclic group or R3 and R2 together with the adjacent nitrogen atom represent a heterocyclic group, R4 represents a hydrogen atom, an alkyl or alkoxy group having 1 to 4 carbon atoms or a halogen atom, Het represents a substituted or unsubstituted heterocyclic group containing two or three heteroatoms and tautomers thereof and acid addition salts of the aforesaid compound. Processes for the preparation of the compounds of formula (I) as well as pharmaceutical compositions containing them are also object of this invention. The new compounds are H2- receptor blocking agents which inhibit gastric acid secretion, and are useful antiulcer agents.

  本发明的目的是下式的具有药理活性的新的取代胍基杂环苯胺类化合物 其中 R、R 和 R2 可以相同或不同，各自代表氢原子或具有 1 至 4 个碳原子的烷基，R3 代表含有氧原子、硫原子或氮原子等杂原子的直链或支链烷基、直链或支链烯基、炔基、氰基、环烷基或环脂族烷基、双环基、芳基、杂环基、R3和R2连同邻近的氮原子代表杂环基团，R4代表氢原子、具有1至4个碳原子的烷基或烷氧基或卤素原子，Het代表含有两个或三个杂原子的取代或未取代的杂环基团及其同系物和上述化合物的酸加成盐。制备式（I）化合物以及含有它们的药物组合物的工艺也是本发明的目的。新化合物是 H2- 受体阻断剂，可抑制胃酸分泌，是有用的抗溃疡剂。
• US4548944A
  申请人：——

  公开号：US4548944A

  公开（公告）日：1985-10-22
• US4645841A
  申请人：——

  公开号：US4645841A

  公开（公告）日：1987-02-24