(1R,3R,6R,7R)-3-hydroxy-10-(4-hydroxy-3-methoxyphenyl)-8-[(2R,3R)-3,5,7-trihydroxy-4-oxo-2,3-dihydrochromen-2-yl]-4-oxatricyclo[4.3.1.03,7]dec-8-en-2-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: (1R,3R,6R,7R)-3-hydroxy-10-(4-hydroxy-3-methoxyphenyl)-8-[(2R,3R)-3,5,7-trihydroxy-4-oxo-2,3-dihydrochromen-2-yl]-4-oxatricyclo[4.3.1.03,7]dec-8-en-2-one
• 化学式: C₂₅H₂₂O₁₀
• 分子量: 482.4
• InChiKey: CYGIJEJDYJOUAN-TZSXPPMOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  35
• 可旋转键数：
  3
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  163
• 氢给体数：
  5
• 氢受体数：
  10

文献信息

• Antihepatotoxic agents
  申请人：KING SAUD UNIVERSITY

  公开号：US10052326B1

  公开（公告）日：2018-08-21

  Antihepatotoxic agents include dihydropyrimidinone derivatives with 1,4-benzodioxane. The antihepatotoxic agents are compounds having the structural formula represented by Formula 1: wherein each Z independently represents O, N or S; X represents O or S; R represents aryl, substituted aryl, heteroaryl, or substituted heteroaryl; and pharmaceutically acceptable salts of these compounds.

  抗肝毒性剂包括具有1,4-苯并二氧杂环庚烷的二氢嘧啶酮衍生物。这些抗肝毒性剂是具有由化学式1表示的结构式的化合物：其中每个Z独立地表示O、N或S；X表示O或S；R表示芳基、取代芳基、杂环芳基或取代杂环芳基；以及这些化合物的药用可接受盐。
• [EN] PHOSPHORYLATED POLYPHENOLS AS COLOUR-STABLE AGENTS<br/>[FR] POLYPHENOLS PHOSPHORYLES UTILISES COMME AGENTS DE COULEUR STABLE
  申请人：AJINOMOTO OMNICHEM S A

  公开号：WO2006029483A1

  公开（公告）日：2006-03-23

  The present invention relates to phosphorylated polyphenols, preferably tannins that, unlike their unphosphorylated counterparts, do not suffer from relatively low stability, resulting in an activity that is relatively short in time, and/or that do not result in yellowing of materials therewith such as textiles or polymers. The present invention further relates to a simple, cheap and environmentally friendly way of preparing these compounds. The phosphorylation process of the invention can be extended to simple phenolic compounds as well, as long as these have at least one accessible hydroxyl group. The phosphorylated compounds according to the invention can be used as antioxidants, as radical scavengers, as complexating agents for metals and proteins, as antibacterials or antiallergenic compounds, and as agents to flock textile.

  本发明涉及磷酸化多酚，优选为单宁，与其未磷酸化的对应物不同，它们不会因相对稳定性较低而导致活性时间相对较短和/或不会导致材料变黄，例如纺织品或聚合物。本发明还涉及一种简单、廉价和环保的制备这些化合物的方法。本发明的磷酸化过程也可以扩展到简单的酚类化合物，只要它们至少有一个可接近的羟基。根据本发明磷酸化的化合物可用作抗氧化剂、自由基清除剂、金属和蛋白质络合剂、抗菌或抗过敏化合物以及用于絮凝纺织品的剂。
• [EN] TOPICAL COMPOSITIONS CONTAINING PHOSPHORYLATED POLYPHENOLS<br/>[FR] COMPOSITIONS TOPIQUES CONTENANT DES POLYPHENOLS PHOSPHORYLES
  申请人：AJINOMOTO OMNICHEM S A

  公开号：WO2006029484A1

  公开（公告）日：2006-03-23

  The present invention provides topical compositions containing phosphorylated polyphenols in combination with a topically acceptable carrier. The compositions of the invention provide a means for delayed delivery of the polyphenol to keratinous tissues, such as skin, hair and nails, with enzymes of the keratinous tissue dephosphorylating the polyphenol, and returning it to its native active form. The compositions are particularly useful in the regulation of skin conditions.

  本发明提供了含有磷酸化多酚的局部组成物，与局部可接受的载体相结合。本发明的组成物提供了一种延迟将多酚传递到角质组织（如皮肤、头发和指甲）的手段，角质组织的酶去磷酸化多酚，并将其返回其原生活性形式。该组成物在调节皮肤状况方面特别有用。
• Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
  申请人：Scaramuzzino, Giovanni

  公开号：EP1336602A1

  公开（公告）日：2003-08-20

  New pharmaceutical compounds of general formula (I): F-(X)q where q is an integer from 1 to 5, preferably 1; -F is chosen among drugs described in the text, -X is chosen among 4 groups -M, -T, -V and -Y as described in the text. The compounds of general formula (I) are nitrate prodrugs which can release nitric oxide in vivo in a controlled and selective way and without hypotensive side effects and for this reason they are useful for the preparation of medicines for prevention and treatment of inflammatory, ischemic, degenerative and proliferative diseases of musculoskeletal, tegumental, respiratory, gastrointestinal, genito-urinary and central nervous systems.

  通式（I）的新药物化合物：F-（X）q，其中q是1到5的整数，最好是1；-F是在文本中描述的药物中选择的，-X是在文本中描述的4个组-M，-T，-V和-Y中选择的。通式（I）的化合物是硝酸盐前药，可以在体内以受控和选择性的方式释放一氧化氮，而不会产生降压副作用，因此它们非常适用于制备用于预防和治疗肌肉骨骼，皮肤，呼吸，消化，泌尿和中枢神经系统的炎症，缺血，退行性和增生性疾病的药物。
• [EN] TRANS APOVINCAMINIC ACID ESTER DERIVATIVES AS DRUGS<br/>[FR] DERIVES D'ESTERS DE L'ACIDE TRANS APOVINCAMINIQUE UTILISES COMME MEDICAMENTS
  申请人：RICHTER GEDEON VEGYÉSZETI GYÁR RT.

  公开号：WO1997023481A1

  公开（公告）日：1997-07-03

  (EN) The invention relates to novel racemic and optically active trans apovincaminic acid ester derivatives of formula (I), wherein R means hydrogen or a group (a), wherein Z stands for C1-4 alkyl, optionally substituted aryl, aralkyl, heteroaryl or 14-eburnameninyl group; and n is an integer of 2, 3 or 4, as well as therapeutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing these compounds as well as a process for the preparation of the above compounds and compositions, and in addition, to a method of treatment. The novel compounds of formula (I) exhibit particularly antioxidant, antiischemic as well as antiamnesic effects and are useful for inhibiting lipid peroxidation and for protection from or treatment of ischemia and amnesia as well as for treating various degenerative neurological diseases, e.g. Alzheimer's disease.(FR) L'invention se rapporte à de nouveaux dérivés racémiques et optiquement actifs d'esters de l'acide trans apovincaminique représentés par la formula (I) dans laquelle R désigne l'hydrogène ou un groupe (a), où Z est alkyle C1-4 ou un groupe aryle, aralkyle, hétéroaryle ou 14-éburnaméninyle éventuellement substitué et n est un entier égal à 2, 3 ou 4. L'invention se rapporte également aux sels pharmaceutiquement acceptables de ces dérivés. L'invention se rapporte en outre à des compositions pharmaceutiques contenant ces composés, à un procédé de préparation des composés et compositions décrits ci-dessus ainsi qu'à une méthode de traitement. Les nouveaux composés représentés par la formule (I) ont des effets particulièrement antioxydants, antiischémiques et anti-amnésiques et ils s'avèrent utiles s'agissant d'inhiber la peroxydation lipidique, de prévenir ou de traiter l'ischémie et l'amnésie, de même que s'agissant de traiter diverses maladies neurodégénératives telles que la maladie d'Alzheimer.

  本发明涉及一种新的手性和外消旋的trans apovincaminic酸酯衍生物，其化学式为(I)，其中R表示氢或一个基团(a)，其中Z代表C1-4烷基，可选取代芳基，芳基烷基，杂环芳基或14-eburnameninyl基团；n是2、3或4的整数，以及其治疗上可接受的盐。本发明还涉及含有这些化合物的药物组成物，以及制备上述化合物和组成物的方法，此外，还涉及一种治疗方法。化学式(I)的新化合物表现出特别的抗氧化、抗缺血以及抗遗忘症效果，可用于抑制脂质过氧化和预防或治疗缺血和遗忘症，以及治疗各种退行性神经疾病，例如阿尔茨海默病。