Methyl-methoxy-methyl-malonsaeure-diethylester | 21398-92-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl-methoxy-methyl-malonsaeure-diethylester
• 英文别名: Methoxymethyl-methylmalonsaeurediethylester；2-methoxymethyl-2-methyl malonic acid；methoxymethyl-methyl-malonic acid diethyl ester；Methoxymethyl-methyl-malonsaeure-diaethylester；1,3-Diethyl 2-(methoxymethyl)-2-methylpropanedioate；diethyl 2-(methoxymethyl)-2-methylpropanedioate
• CAS: 21398-92-5
• 化学式: C₁₀H₁₈O₅
• mdl: MFCD26085168
• 分子量: 218.25
• InChiKey: GVLURZHLOJMFIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Methyl-methoxy-methyl-malonsaeure-diethylester 在 lithium aluminium tetrahydride 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 5-methoxymethyl-5-methyl-1,3-dioxan-2-one
  参考文献：
  名称：

  Aliphatic Polycarbonates Produced from the Coupling of Carbon Dioxide and Oxetanes and Their Depolymerization via Cyclic Carbonate Formation

  摘要：

  The (salen)CrCl/onium salt catalyzed coupling reactions of several oxetane derivatives and carbon dioxide are reported. The oxetanes investigated contain substituents in the 3-position covering a range of steric requirements. The oxetanes examined include, 3,3-dimethyloxetane, 3-methoxymethyl-3-methyloxetane, and 3-benzyloxymethyl-3-methyloxetane. The rates of reaction of these oxetanes with CO2 were found to be significantly slower than the corresponding process with the parent oxetane monomer. Furthermore, in these instances the formation of copolymer was found to proceed via the preformed cycloaddition product, i.e., the six-membered cyclic carbonate, to a greater extent and increasing with the steric bulk of the substituents on oxetane. For these sterically more hindered oxetanes, the CO2 coupling reaction carried out in toluene at 110 degrees C reached an equilibrium product distribution of copolymer to cyclic carbonate which increased in cyclic carbonate product with increasing steric requirements of the oxetane monomer. For example, the catalyzed coupling of the parent oxetane and CO2 provides a copolymer to cyclic carbonate ratio of greater than 95%, whereas the corresponding product distribution for 3-benzyloxymethyl-3-methyloxetane was observed to be 60%. The catalytic rate of depolymerization of a purified sample of the copolymer afforded from 3-benzyloxymethyl-3-methyloxetane and CO2 to the corresponding cyclic carbonate, 5-benzyloxymethyl-5-methyl-1,3-dioxan-2-one, was found to be greatly retarded when carried out in an atmosphere of CO2.

  DOI：

  10.1021/ma2002323
• 作为产物：
  描述：

  二氯甲基醚 、 甲基丙二酸二乙酯 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 反应 3.0h， 生成 Methyl-methoxy-methyl-malonsaeure-diethylester
  参考文献：
  名称：

  Dienoalkyl ethers. General synthesis of the symmetrical ethers

  摘要：

  DOI：

  10.1021/jo00978a029

文献信息

• Struktur von Coleon C, einem neuen Blattfarbstoff aus<i>Coleus aquaticus Gürcke</i>
  作者：P. Rüedi、C. H. Eugster

  DOI：10.1002/hlca.19710540612

  日期：——

  From the yellow glands on the leaves and inflorescences of Coleus aquaticus Gürcke (Labiatae) a new, yellow diterpenoid hydroquinone, coleon C, C20H26O6, was isolated and its structure elucidated as 1. The compound contains a novel 1-hydroxyprop-2-yl-side chain at C(13).

  从锦紫苏叶片（Labiatae）的叶和花序上的黄色腺体中分离出一种新的黄色二萜类对苯二酚对苯二酚C，C 20 H 26 O 6，其结构鉴定为1。该化合物在C处含有一个新的1-羟基丙-2-基侧链（13）。
• Wagner, Journal of the American Chemical Society, 1949, vol. 71, p. 3216
  作者：Wagner

  DOI：——

  日期：——
• Butova,T.D. et al., Journal of general chemistry of the USSR, 1971, vol. 41, p. 2028 - 2031
  作者：Butova,T.D. et al.

  DOI：——

  日期：——
• Alkoxy compounds
  作者：Yu. Yu. Samitov、G. I. Goryashina、A. V. Bogatskii、O. S. Stepanova

  DOI：10.1007/bf00486754

  日期：——
• Phospholipide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
  申请人：BOEHRINGER MANNHEIM GMBH

  公开号：EP0069968B1

  公开（公告）日：1985-11-21