12-Methoxystearinsaeuremethylester | 2566-92-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 12-Methoxystearinsaeuremethylester
• 英文别名: Methyl 12-methoxystearate；methyl 12-methoxyoctadecanoate
• CAS: 2566-92-9；7705-97-7
• 化学式: C₂₀H₄₀O₃
• 分子量: 328.536
• InChiKey: HOFDTWANWBQVEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  23
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  二碘甲烷 、 12-羟基硬脂酸甲酯 在 铜 、 锌 作用下， 以 乙醚 为溶剂， 生成 12-Methoxystearinsaeuremethylester
  参考文献：
  名称：

  Ansari,F.H. et al., Indian Journal of Chemistry, 1973, vol. 11, p. 1053 - 1054

  摘要：

  DOI：

文献信息

• AMINE DERIVATIVE AND DERMATOLOGIC PREPARATION CONTAINING THE SAME
  申请人：Kao Corporation

  公开号：EP0691327A1

  公开（公告）日：1996-01-10

  An amine derivative of following general formula (I) or (II) (wherein R1 represents a heteroatom-containing C1-C40 hydrocarbon group which may have a ring structure, etc.; R2 to R6 each represent a C1-C10 hydrocarbon group, hydrogen, etc.; A1 represents (i) or R15-Z-R16(CH2)n-; B1 represents hydrogen, a C1-C10 hydrocarbon group, nitrogen, etc.; and C1 represents hydrogen, a C1-C10 hydrocarbon group, nitrogen, alcohol residue, phosphoric acid residue, etc.); a dermatologic preparation containing the same; and a process for producing the amine derivative. The amine derivative has excellent effects of smoothing wrinkles and improving keratodermia.

  以下通式(I)或(II)的胺衍生物（其中 R1 代表含杂原子的 C1-C40 烃基，可具有环状结构等；R2 至 R6 各代表 C1-C10 烃基、氢等；A1 代表(i)或 R15-Z-R16(CH2)n- ；B1 代表氢、C1-C10 烃基、氮等；C1 代表氢、C1-C10 烃基、氮等）。A1代表(i)或 R15-Z-R16(CH2)n-；B1代表氢、C1-C10 烃基、氮等；C1代表氢、C1-C10 烃基、氮、醇残留物、磷酸残留物等）；含有相同成分的皮肤病制剂；以及生产胺衍生物的工艺。胺衍生物在抚平皱纹和改善角质层方面具有卓越的效果。
• Neighboring methoxyl participation in the acid catalyzed methoxylation of methylene-interrupted fatty acids
  作者：Néstor M. Carballeira、Marı́a V. González、Mayra Pagán

  DOI：10.1016/s0009-3084(97)00062-5

  日期：1997.10

  The boron trifluoride-methanol derivatization of methyl 9,12-octadecadienoate was studied. This methylene-interrupted diene was reacted with 50% BF3-MeOH for 15 h at 0-5 degrees C and the four monomethoxy and two dimethoxy derivatives thus obtained were analyzed by gas chromatography-mass spectrometry. The only dimethoxy adducts observed were characterized as methyl 9,12-dimethoxyoctadecanoate and methyl 10,13-dimethoxyoctadecanoate. The complete regiospecificity observed in the formation of the dimethoxy adducts is best explained by a common O-methyltetrahydrofuranium ion as the only intermediate under these reaction conditions. (C) 1997 Elsevier Science Ireland Ltd.
• Pharmaceutical Formulation
  申请人：Benard Tsiala

  公开号：US20120202831A1

  公开（公告）日：2012-08-09

  The invention relates to a pharmaceutical formulation including, as an active principle, the compound of formula (I) or a salt of said compound with a pharmaceutically acceptable acid.
• US5723497A
  申请人：——

  公开号：US5723497A

  公开（公告）日：1998-03-03
• Ansari,F.H. et al., Indian Journal of Chemistry, 1973, vol. 11, p. 1053 - 1054
  作者：Ansari,F.H. et al.

  DOI：——

  日期：——