Myr-DL-Val | 83871-19-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Myr-DL-Val
• 英文别名: N-tetradecanoyl-DL-valine；myristoyl valine；N-Tetradecanoylvaline；3-methyl-2-(tetradecanoylamino)butanoic acid
• CAS: 83871-19-6
• 化学式: C₁₉H₃₇NO₃
• 分子量: 327.508
• InChiKey: XGYJHOKDLDLGLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  23
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  alpha-D-半乳糖 、 Myr-DL-Val 在 lipozyme thermomyces lanuginosus immobilized on silica 作用下， 以 叔丁醇 为溶剂， 反应 6.0h， 以78.5%的产率得到1-O-(N-myristylvalineyl)-D-galactosyl ester
  参考文献：
  名称：

  Enzymatic synthesis and characterization of galactosyl monoesters

  摘要：

  Enzyme-catalyzed synthesis of several fatty acyl-amino acid esters based on D-galactose, as well as their chemical evaluation, was performed. These novel galactosyl fatty acyl-amino acid monoesters were synthesized by utilizing lipase from lipozyme TL IM in tert-butanol with D-galactose and fatty acyl-amino acids as starting materials. The products were characterized by H-1 NMR, C-13 NMR and MS analysis. In addition, their primary physical properties, such as hydrophilic-lipophilic balance (HLB), critical micellar concentration (CMC), solubility in water, maximum surface excess (Gamma(max)), and minimal surface tension (A(min)) were measured. The experimental results showed that their CMC values are between 5 and 0.4 mM. The HLB values of galactosyl esters 15-17 indicate that they are useful as oil-in-water emulsions or detergents, whereas 18-22 can be employed as water-in-oil emulsifiers or wetting agents. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2015.05.011
• 作为产物：
  描述：

  sodium DL-2-aminoisovalerate 、 肉豆蔻酰氯 以 水 为溶剂， 反应 1.0h， 生成 Myr-DL-Val
  参考文献：
  名称：

  Iyer, Venkataraman N.; Sheth, Geeta N.; Subrahmanyam, V. V. R., Journal of the Indian Chemical Society, 1982, vol. 59, # 7, p. 856 - 859

  摘要：

  DOI：

文献信息

• 一种N-脂肪酰基氨基酸酰胺糖胺及其制备工 艺
  申请人：北京工商大学

  公开号：CN110642898B

  公开（公告）日：2021-03-23

  本发明提供了一种脂肪酸甲酯和氨基酸、葡萄糖和二胺为原料制备N‑脂肪酰基氨基酸酰胺糖胺的工艺。该工艺是将氨基酸碱化后与脂肪酸甲酯反应得到N‑脂肪酰基氨基酸，然后N‑脂肪酰基氨基酸与二胺反应得到N‑脂肪酰基氨基酸酰胺，最后N‑脂肪酰基氨基酸酰胺与葡萄糖反应制得N‑脂肪酰基氨基酸酰胺糖胺。本发明提供的N‑脂肪酰基氨基酸酰胺糖胺制备工艺，制备简单，无需加入毒性较强试剂和氢化还原试剂，减少了对环境的污染，产物提纯容易和收率高，产物的表面张力为26‑37mN/m。
• DE2234399
  申请人：——

  公开号：——

  公开（公告）日：——
• AN ENZYME-CATALYZED PROCESS FOR PREPARING N-ACYL AMINO ACIDS AND N-ACYL AMINO ACID AMIDES
  申请人：NOVO NORDISK A/S

  公开号：EP0473700A1

  公开（公告）日：1992-03-11
• Utilisation d'ester d'isosorbide et de dérivés N-acylés d'acides aminés comme agent antivieillissement de la peau humaine
  申请人：Société d'Exploitation de Produits pour les Industries Chimiques SEPPIC

  公开号：EP3209277A1

  公开（公告）日：2017-08-30
• USE OF ISOSORBIDE ESTER AND N-ACYLATED AMINO ACID DERIVATIVES AS ANTI-AGEING AGENT FOR THE HUMAN SKIN
  申请人：SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC

  公开号：US20170304177A1

  公开（公告）日：2017-10-26

  A compound of formula (I) is disclosed, in which R′ and R″, which may be identical or different, represent either a hydrogen atom or a monovalent radical of formula (IIa); or of a composition (C1) including between 99% and 20% by mass of a compound of formula (Ia), and between 1% and 80% by mass of a compound of formula (1b), with the aim of preventing or retarding the appearance of the signs of ageing of the human skin or lips or to eliminate the signs, the use being in the form of a cosmetic composition. Also disclosed is a method using the product of formula (I) or composition (C1).