5-methoxy-1,1-dimethyl-2-(di-n-propylamino)tetralin | 112904-86-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 5-methoxy-1,1-dimethyl-2-(di-n-propylamino)tetralin
• CAS: 112904-86-6
• 化学式: C₁₉H₃₁NO
• 分子量: 289.461
• InChiKey: XYLJWGJAINVASK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.41
• 重原子数：
  21.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  12.47
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  5-methoxy-1,1-dimethyl-2-tetralone 在 platinum(IV) oxide lithium aluminium tetrahydride 、 4 A molecular sieve 、 氢气 、 溶剂黄146 、 三乙胺 作用下， 以 四氢呋喃 、 乙醚 、 乙醇 为溶剂， 25.0~80.0 ℃ 、101.33 kPa 条件下， 反应 4.5h， 生成 5-methoxy-1,1-dimethyl-2-(di-n-propylamino)tetralin
  参考文献：
  名称：

  C1-Methylated 5-hydroxy-2-(dipropylamino)tetralins: central dopamine-receptor stimulating activity

  摘要：

  C1-Methylated derivatives of the potent dopaminergic agonist 5-hydroxy-2-(di-n-propylamino)tetralin (6) have been synthesized and tested for central dopamine (DA) receptor stimulating activity, by using biochemical and behavioral tests in rats. Both cis- and trans-5-hydroxy-1-methyl-2-(di-n-propylamino) tetralin (4 and 3) may be classified as central DA-receptor agonists, albeit of lower potency than 6. The results obtained indicate that both 4 and 3 display DA-autoreceptor stimulation capacity. However, only one of the isomers, trans-3, is able to elicit clear-cut postsynaptic DA receptor agonist actions at larger doses. 5-Hydroxy-1,1-dimethyl-2-(n-propylamino) tetralin (5) was found to be inactive.

  DOI：

  10.1021/jm00374a012

文献信息

• C1-Methylated 5-hydroxy-2-(dipropylamino)tetralins: central dopamine-receptor stimulating activity
  作者：Uli Hacksell、Anette M. Johansson、Lars Erik Arvidsson、J. Lars G. Nilsson、Stephan Hjorth、Arvid Carlsson、Hakan Wikstroem、Domingo Sanchez、Per Lindberg

  DOI：10.1021/jm00374a012

  日期：1984.8

  C1-Methylated derivatives of the potent dopaminergic agonist 5-hydroxy-2-(di-n-propylamino)tetralin (6) have been synthesized and tested for central dopamine (DA) receptor stimulating activity, by using biochemical and behavioral tests in rats. Both cis- and trans-5-hydroxy-1-methyl-2-(di-n-propylamino) tetralin (4 and 3) may be classified as central DA-receptor agonists, albeit of lower potency than 6. The results obtained indicate that both 4 and 3 display DA-autoreceptor stimulation capacity. However, only one of the isomers, trans-3, is able to elicit clear-cut postsynaptic DA receptor agonist actions at larger doses. 5-Hydroxy-1,1-dimethyl-2-(n-propylamino) tetralin (5) was found to be inactive.