2-hydroxy-N-methoxy-N-methylacetamide | 78937-02-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-hydroxy-N-methoxy-N-methylacetamide
• 英文别名: N-methyl-N-methoxyhydroxyacetic acid amide；hydroxyacetic acid N-methyl-N-methoxy-amide
• CAS: 78937-02-7
• 化学式: C₄H₉NO₃
• 分子量: 119.12
• InChiKey: FMHHOIZBAJLSFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-hydroxy-N-methoxy-N-methylacetamide 在 咪唑 、 叔丁基二甲基氯硅烷 作用下， 以 二氯甲烷 为溶剂， 以98 %的产率得到2-((tert-butyldimethylsilyl)oxy)-N-methoxy-N-methylacetamide
  参考文献：
  名称：

  [EN] ALPHA 4 BETA 7 INTEGRIN MODULATORS AND USES THEREOF
  [FR] MODULATEURS DE L'INTÉGRINE ALPHA 4 BÊTA 7 ET LEURS UTILISATIONS

  摘要：

  The present disclosure provides small molecule compounds and pharmaceutical compositions for the modulation of alpha 4 beta 7 integrin, useful for the treatment of inflammatory conditions such as inflammatory bowel disease, including ulcerative colitis and Crohn's disease.

  公开号：

  WO2023220741A1
• 作为产物：
  描述：

  2-[methoxy(methyl)amino]-2-oxoethyl acetate 在 甲醇 、 sodium methylate 作用下， 反应 3.0h， 以91.6%的产率得到2-hydroxy-N-methoxy-N-methylacetamide
  参考文献：
  名称：

  [EN] PROCESS FOR THE PREPARATION OF A GLUCOKINASE ACTIVATOR COMPOUND
  [FR] PROCÉDÉ DE PRÉPARATION D'UN COMPOSÉ ACTIVATEUR DE GLUCOKINASE

  摘要：

  本发明涉及一种制备化合物（I）的方法，其中R1为C1-6-烷基，R2为氢或卤素。化合物（I）的(R)-2-苯基丙酸衍生物是5-取代吡啶或吡啶葡萄糖激酶激活剂合成中的关键中间体，如PCT国际专利申请号WO 2004/052869 A1所披露的，这些化合物具有潜力用作葡萄糖激酶激活剂，可用于治疗和/或预防II型糖尿病。

  公开号：

  WO2011023706A1

文献信息

• PROCESS FOR THE PREPARATION OF A GLUCOKINASE ACTIVATOR COMPOUND
  申请人：Bachmann Stephan

  公开号：US20110054174A1

  公开（公告）日：2011-03-03

  The present invention relates to a process for the preparation of a compound of formula I, wherein R 1 is C 1-6 -alkyl and R 2 is hydrogen or halogen. (R)-2-phenyl propionic acid derivatives of formula I are key intermediates in the synthesis of 5-substituted-pyrazine or pyridine glucokinase activators of the formula Xa, which have the potential to be useful for the treatment and/or prophylaxis of type II diabetes.

  本发明涉及一种制备式I化合物的方法，其中R1为C1-6烷基，R2为氢或卤素。式I的(R)-2-苯基丙酸衍生物是合成式Xa的5-取代吡嗪或吡啶葡萄糖激酶激活剂的关键中间体，这些激活剂有可能用于治疗和/或预防II型糖尿病。
• Azolyloxy-carboxylic acid n-oxy-amide compounds
  申请人：Bayer Aktiengesellschaft

  公开号：US04408055A1

  公开（公告）日：1983-10-04

  Azolyloxy-carboxylic acid N-oxy-amide compound of the formula ##STR1## wherein R is a five-membered hetero-aromatic monocyclic radical which contains an oxygen atom or a sulphur atom and in addition 1 to 3 nitrogen atoms and which is optionally substituted by halogen, cyano, nitro, amino, alkylamino, arylamino, dialkylamino, alkylcarbonylamino, alkylcarbonyl, carboxyl, alkoxycarbonyl, carbamoyl, alkylaminocarbonyl, dialkylaminocarbonyl, arylaminocarbonyl (which is optionally substituted by halogen, nitro or alkyl), aryl (which is optionally substituted by halogen, cyano, nitro, alkyl or alkoxy), by a radical which is optionally substituted by halogen and is selected from aralkyl, alkoxy, alkenoxy, alkynoxy, alkoxycarbonylalkoxy, aralkoxy, aryloxy, alkylthio, alkenylthio, alkoxycarbonylalkylthio, aralkylthio, arylthio, alkylsulphinyl, alkylsulphonyl, alkyl, alkenyl, alkynyl, alkoxyalkyl, aralkoxyalkyl, aryloxyalkyl, alkylthioalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl, arylthioalkyl, arylsulphinylalkyl, arylsulphonylalkyl, carboxyalkyl, and alkoxycarbonylalkyl, or by optionally substituted aminocarbonylalkyl, cyanoalkyl or cycloalkyl, or which is optionally benzo-fused, the benzo radical optionally being substituted by halogen, alkyl, halogenoalkyl, alkoxy, halogenoalkoxy, alkylthio, halogenoalkylthio, amino, alkylamino, dialkylamino, nitro, cyano, alkoxycarbonyl or optionally halogen-substituted alkylenedioxy, R.sup.1 is hydrogen or alkyl, and R.sup.2 and R.sup.3 are individually selected from optionally substituted radicals selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, aryl or R.sup.2 and R.sup.3 taken together represent alkylene are effective herbicides.

  Azolyloxy-羧酸N-氧基酰胺化合物的化学式为##STR1##其中R是一个含有氧原子或硫原子的五元杂环芳香单环基团，另外还包括1至3个氮原子，并且可以被卤素、氰基、硝基、氨基、烷基氨基、芳基氨基、二烷基氨基、烷基羰胺基、烷基羰基、羧基、烷氧羰基、氨基甲酰基、烷基氨基甲酰基、二烷基氨基甲酰基、芳基氨基甲酰基（可以被卤素、硝基或烷基取代）、芳基（可以被卤素、氰基、硝基、烷基或烷氧基取代）、或者被一个可以被卤素取代的基团选自芳基烷基、烷氧基、烯氧基、炔氧基、烷氧羰基烷氧基、芳基烷氧基、芳氧基、烷硫基、烯硫基、烷氧羰基烷硫基、芳基烷硫基、芳硫基、烷砜基、烷砜基、烷基、烯基、炔基、烷氧基烷基、芳基烷氧基、芳氧基烷基、烷硫基烷基、烷砜基烷基、烷砜基烷基、芳硫基烷基、芳砜基烷基、芳砜基烷基、羧基烷基和烷氧羰基烷基，或者是可选地取代的氨基羰基烷基、氰基烷基或环烷基，或者是可选地苯并的，苯基团可以被卤素、烷基、卤代烷基、烷氧基、卤代烷氧基、烷硫基、卤代烷硫基、氨基、烷基氨基、二烷基氨基、硝基、氰基、烷氧羰基或可选地卤代烷二氧基取代，R.sup.1是氢或烷基，R.sup.2和R.sup.3分别选自可选取代的基团，所选取自烷基、烯基、炔基、环烷基、芳基或R.sup.2和R.sup.3一起代表亚烷基的基团是有效的除草剂。
• Propionic acid derivatives and herbicides employing them
  申请人：Agro-Kanesho Co., Ltd.

  公开号：US04600432A1

  公开（公告）日：1986-07-15

  Propionic acid derivatives represented by the formula (I) ##STR1## wherein X indicates an oxygen atom or a sulfur atom, Y indicates a hydrogen atom or a halogen atom, R.sub.1 and R.sub.2 are the same or different group, indicating an alkyl group, alkenyl group, alkynyl group, cycloalkyl group, lower alkoxy group, lower alkoxyalkyl group, phenyl group, respectively, or R.sub.1 and R.sub.2 may form a heterocyclic group together with a nitrogen atom bonding to said R.sub.1 and R.sub.2, and herbicidal compositions employing them.

  式(I)所代表的丙酸衍生物为 ##STR1## 其中X表示氧原子或硫原子，Y表示氢原子或卤素原子，R.sub.1和R.sub.2是相同或不同的基团，表示烷基，烯基，炔基，环烷基，较低的烷氧基，较低的烷氧基烷基，苯基，或者R.sub.1和R.sub.2可以与氮原子结合形成杂环基团，以及采用它们的除草剂组合物。
• Expedient Synthesis of 3-Alkoxymethyl- and 3-Aminomethyl-Pyrazolo[3,4-<i>b</i>]pyridines
  作者：Gregory L. Beutner、Jeffrey T. Kuethe、Mary M. Kim、Nobuyoshi Yasuda

  DOI：10.1021/jo802363q

  日期：2009.1.16

  An effective strategy has been developed for the preparation of 3-alkoxymethyl-pyrazolo[3,4-b]pyridines, compounds that are currently not readily accessible by existing synthetic methods. Further manipulation of these compounds allows for access to 3-alkoxymethyl-pyrazolo[3,4-b]pyridines with a variety of substitution patterns as well as 3-aminomethyl-pyrazolo[3,4-b]pyridines.
• Enhanced Enantioselectivity of Molecularly Imprinted Polymers Formulated with Novel Cross-Linking Monomers
  作者：Martha Sibrian-Vazquez、David A. Spivak

  DOI：10.1021/ma025710z

  日期：2003.7.1

  To enhance the performance of molecularly imprinted polymers (MlPs), three new cross-linking monomers were designed, synthesized, and evaluated as matrix elements for molecularly imprinted polymers. Hybrid cross-linking monomers incorporating methacrylamide/methacrylate (NOBE), vinyl ketone/methacrylamide (NAG), and vinyl ketone/methacrylate (MVK) polymerizable groups, were synthesized and used to prepare MIPs and compared to a traditional MIP formulated with EGDMA. The resulting macroporous MIPs were evaluated by HPLC for their ability to separate the enantiomers of a chiral template. The MIP formulated with the cross-linking monomer NAG showed the highest enantioselectivity and complete baseline resolution for a racemic mixture of the template. Enhancement in selectivity in this MIP may be attributed to the presence of the amide group which can promote hydrogen bonding via favorable 1,3 donor-acceptor interactions with the template, the morphology of the polymeric material obtained due to differences in reactivity between the polymerizable groups and improved resolution in cavity formation as a consequence of shorter cross-linker size.