N-[3-(4-benzoylbenzoamido)propyl]methacrylamide | 165391-55-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[3-(4-benzoylbenzoamido)propyl]methacrylamide
• 英文别名: N-[3-(4-Benzoylbenzamido)propyl]methacrylamide；4-Benzoyl-N-[3-(2-methyl-acryloylamino)-propyl]-benzamide；4-benzoyl-N-[3-(2-methylprop-2-enoylamino)propyl]benzamide
• CAS: 165391-55-9
• 化学式: C₂₁H₂₂N₂O₃
• 分子量: 350.417
• InChiKey: KKGFAULLJCULTN-UHFFFAOYSA-N

物化性质

• 沸点：
  627.4±55.0 °C(Predicted)
• 密度：
  1.138±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  75.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吩噻嗪 、 4-苯甲酰基苯甲酰氯 在 盐酸 、 三乙醇胺 作用下， 以 氯仿 、 甲苯 为溶剂， 以90%的产率得到N-[3-(4-benzoylbenzoamido)propyl]methacrylamide
  参考文献：
  名称：

  Latent reactive blood compatible agents

  摘要：

  一种试剂和相关方法，用于在钝化生物材料表面中使用，所述试剂包括一个潜在的反应基团和一个双功能脂肪酸（例如脂肪酸），与一个连接潜在反应基团与脂肪酸的间隔基团结合在一起，以保持每个基团的所需功能。一旦通过潜在的反应基团结合到表面，该试剂将脂肪酸呈现给体内的生理环境，以一种足以保持和定向白蛋白的方式（例如浓度和取向）。

  公开号：

  US06465525B1

文献信息

• PHOTO-VINYL LINKING AGENTS
  申请人：Swan Dale G.

  公开号：US20130143056A1

  公开（公告）日：2013-06-06

  Embodiments of the invention include linking agents including photo groups and vinyl groups and coatings and devices that incorporate such linking agents, along with related methods. Exemplary methods herein include methods of priming substrates and methods of coating substrates using compounds having the formula R 1 —X—R 2 , wherein R 1 is a radical comprising a vinyl group, X is a radical comprising from about one to about twenty carbon atoms, and R 2 is a radical comprising a photoreactive group. Embodiments herein also include linking agents having the formula R 1 —X—R 2 , wherein R 1 is a radical comprising a vinyl group, X is a radical comprising from about one to about twenty carbon atoms, and R 2 is a radical comprising a photoreactive group. Other embodiments are also included herein.

  发明的实施例包括连接剂，包括光团和乙烯基和涂层以及包含这种连接剂的设备，以及相关方法。本文的示例方法包括使用具有以下公式的化合物对基板进行打底和涂层的方法R1—X—R2，其中R1是包含乙烯基的基团，X是包含大约一到约二十个碳原子的基团，R2是包含光反应基团的基团。本文的实施例还包括具有以下公式的连接剂R1—X—R2，其中R1是包含乙烯基的基团，X是包含大约一到约二十个碳原子的基团，R2是包含光反应基团的基团。本文还包括其他实施例。
• Polypeptide microparticles having sustained release characteristics, methods and uses
  申请人：Slager Joram

  公开号：US20090022805A1

  公开（公告）日：2009-01-22

  The invention provides polypeptide microparticles having control release features, particular methods for the preparation of such microparticles, and drug delivery systems that include polypeptide microparticles.

  这项发明提供了具有控制释放特性的多肽微粒，以及用于制备这种微粒的特定方法，以及包括多肽微粒的药物输送系统。
• Tissue graft materials containing biocompatible agent and methods of making and using same
  申请人：Stucke Sean M.

  公开号：US20080063627A1

  公开（公告）日：2008-03-13

  The invention provides implantable tissue graft materials composed of a collagenous tissue scaffold and a biocompatible agent bonded to the tissue scaffold via an activated photoreactive group. The invention further provides methods including steps of obtaining a tissue graft material comprising a collagenous tissue scaffold; contacting the collagenous tissue scaffold with a biocompatible agent composition that includes biocompatible agent and one or more photoreactive groups; and treating the collagenous tissue scaffold and biocompatible agent composition to activate the photoreactive groups and bond the biocompatible agent to the tissue scaffold via one or more activated photoreactive groups. Implantable prostheses formed of the tissue graft material are also contemplated.

  该发明提供了由胶原组织支架和通过活化光反应基团与组织支架结合的生物相容剂组成的可植入组织移植材料。该发明还提供了包括以下步骤的方法：获得包括胶原组织支架的组织移植材料；将胶原组织支架与包括生物相容剂和一个或多个光反应基团的生物相容剂组成物接触；并处理胶原组织支架和生物相容剂组成物以激活光反应基团并通过一个或多个活化光反应基团将生物相容剂与组织支架结合。还可以考虑由该组织移植材料形成的可植入假体。
• DELIVERY OF NUCLEIC ACID COMPLEXES FROM MATERIALS INCLUDING NEGATIVELY CHARGED GROUPS
  申请人：McGonigle Joseph Schmidt

  公开号：US20090263449A1

  公开（公告）日：2009-10-22

  Embodiments of the invention include devices and methods for the controlled elution of nucleic acid delivery complexes. In an embodiment, the invention includes a medical device including a substrate surface, a polymeric coating disposed on the surface, the polymeric coating coupled to the substrate surface through the reaction product of a photoreactive group; the polymeric coating comprising negatively charged species on the surface; and a plurality of nucleic acid delivery complexes disposed on the polymeric coating, the nucleic acid delivery complexes comprising a nucleic acid and a cationic carrier agent complexed to the nucleic acid. Other embodiments are included herein.

  本发明的实施例包括用于控制核酸递送复合物释放的装置和方法。在一种实施例中，本发明包括一种医疗器械，其中包括基底表面、沉积在表面上的聚合物涂层，聚合物涂层通过光反应性基团的反应产物与基底表面耦合；聚合物涂层在表面上包含负电荷物种；以及多个核酸递送复合物沉积在聚合物涂层上，核酸递送复合物包括与核酸形成复合物的阳离子载体剂。本发明还包括其他实施例。
• PHOTOACTIVATABLE NUCLEIC ACID DERIVATIVES
  申请人：——

  公开号：US20020086989A1

  公开（公告）日：2002-07-04

  A photoactivatable nucleic acid derivative composition in which one or more photoreactive group(s) are bound to a natural or synthetic nucleic acid. The photoreactive groups can be bound to the nucleic acid before, during or after its formation, and can thereafter be activated in order to attach the nucleic acid to another molecule, e.g., to the surface of a solid support. Also described is a method of preparing such a composition, and a method of using such a composition to attach the nucleic acid to a another molecule, such as that provided by the surface of a substrate used to prepare a nucleic acid chip by photolithographic techniques.

  一种光活性核酸衍生物组合物，其中一个或多个光反应性基团与天然或合成核酸结合。这些光反应性基团可以在核酸形成之前、期间或之后与核酸结合，并随后被激活以将核酸附着到另一分子上，例如固体支持表面。还描述了制备这种组合物的方法，以及使用这种组合物将核酸附着到另一分子的方法，例如通过光刻技术制备核酸芯片所使用的基板表面。