4-allyloxybenzyl chloride | 32078-38-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-allyloxybenzyl chloride
• 英文别名: 1-(allyloxy)-4-(chloromethyl)benzene；p-allyloxybenzyl chloride；1-Allyloxy-4-chloromethyl-benzene；1-(chloromethyl)-4-prop-2-enoxybenzene
• CAS: 32078-38-9
• 化学式: C₁₀H₁₁ClO
• 分子量: 182.65
• InChiKey: VFYLEHMWKPEVTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-allyloxybenzyl chloride 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 18.5h， 以74%的产率得到2-[(4-(chloromethyl)phenoxy)methyl]oxirane
  参考文献：
  名称：

  Fluorinated Isatin Derivatives. Part 2. New N-Substituted 5-Pyrrolidinylsulfonyl Isatins as Potential Tools for Molecular Imaging of Caspases in Apoptosis

  摘要：

  Caspases are responsible for the execution of the cell death program and are potentially suitable targets for the specific imaging of apoptosis in vivo. A series of N-1-substituted analogues of the small molecule nonpeptide caspase inhibitor (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin (1), which may be useful for the development of caspase-targeted radioligands, were synthesized and their inhibition potencies were evaluated in vitro. Two of the most powerful techniques to introduce fluorine into organic compounds, viz, bromofluorination of olefins and fluorohydrin synthesis by ring-opening of epoxides, were used. Most of the target compounds are potent inhibitors of the two effector caspases-3 and -7. Furthermore, the F-18-radiolabeled model compound (S)-1-[4-(1-[F-18]fluoro-2-hydroxyethyl)benzyl]-5-[1-(2-methoxymethyl-pyrrolidinyl)sulfonyl]isatin ([F-18]37), a putative tracer for the noninvasive imaging of apoptosis by positron emission tomography (PET) was synthesized by nucleophilic epoxide ring-opening of its precursor 36. The radiochemistry utilized in the F-18-fluorination reverted to carrier-added [F-18]Et3N center dot 3HF, a new fluorine-18 source for radiolabeling.

  DOI：

  10.1021/jm8015014
• 作为产物：
  描述：

  烯丙基苯基醚 在 盐酸 、 聚合甲醛 、 苯 作用下， 生成 4-allyloxybenzyl chloride
  参考文献：
  名称：

  Substituted benzyloxyarylacetic acids: Synthesis and quantitative relationships between structure and antiinflammatory activity

  摘要：

  DOI：

  10.1135/cccc19771723

文献信息

• [EN] COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES<br/>[FR] COMPOSÉS, SELS CORRESPONDANTS ET MÉTHODES POUR LE TRAITEMENT DE MALADIES
  申请人：ACADIA PHARM INC

  公开号：WO2019040107A1

  公开（公告）日：2019-02-28

  The present disclosure relates to compounds according to Formula (I), useful for treating diseases.

  本公开涉及按照式（I）的化合物，用于治疗疾病。
• Methanesulfinylation of Benzyl Halides with Dimethyl Sulfoxide
  作者：Duo Fu、Jun Dong、Hongguang Du、Jiaxi Xu

  DOI：10.1021/acs.joc.9b03041

  日期：2020.2.21

  this transition-metal-free reaction, DMSO acts as not only a solvent but also a "S(O)Me" source, thus providing a convenient method for the efficient and direct synthesis of various benzyl methyl sulfoxides.

  已经开发了三溴化苯基三甲基铵介导的苄基卤化物与DMSO的亲核取代/氧转化反应。在该无过渡金属的反应中，DMSO不仅充当溶剂，而且充当“ S（O）Me”源，因此为有效且直接合成各种苄基甲基亚砜提供了一种便捷的方法。
• Stable helical ionic polypeptides
  申请人：Cheng Jianjun

  公开号：US09243040B2

  公开（公告）日：2016-01-26

  The invention provides polymers comprising Formula I: wherein monomer is a repeating unit comprising 2, 3, 4, 5, 6 or 7 carbon atoms and the monomers are linked together through amide or ester bonds; n is about 6 to about 1000; and Linker is an optionally substituted carbon chain that is optionally interrupted by moieties such as oxygen, nitrogen, sulfur, phosphorus, or silicon. Charge is a moiety having a positive or negative charge on a heteroatom, such as nitrogen, oxygen, phosphorus, or sulfur; where the Linker separates the monomer and the Charge by at least six linear atoms. The invention also provides methods of preparing the polymers and the copolymers and methods of using the polymers and copolymers, for example, as drug delivery systems, as membrane penetrating peptides, and as therapeutic agents.

  该发明提供了包含以下结构的聚合物： 其中单体是包含2、3、4、5、6或7个碳原子的重复单元，而单体通过酰胺或酯键连接在一起；n约为6至1000；连接物是一种可选择地被氧、氮、硫、磷或硅等基团中断的可选择替代的碳链。电荷是在杂原子（如氮、氧、磷或硫）上具有正电荷或负电荷的基团；其中连接物至少由六个线性原子将单体和电荷分开。该发明还提供了制备这些聚合物和共聚物的方法，以及使用这些聚合物和共聚物的方法，例如作为药物传递系统、膜穿透肽和治疗剂。
• Antiinflammatory substituted phenylacetic acids
  申请人：SPOFA, United Pharmaceutical Works

  公开号：US04221919A1

  公开（公告）日：1980-09-09

  Antiinflammatory substituted phenylacetic acids of low toxicity are prepared by reaction of a salt of an alkyl 3 chloro-4-hydroxyphenylacetate with a substituted benzyl halide in the presence of an inert organic solvent at elevated temperatures.

  低毒性的抗炎替代苯乙酸通过在惰性有机溶剂存在下，在高温下，将烷基3氯-4-羟基苯乙酸盐与替代苄卤化物反应制备而成。
• Indole derivatives
  申请人：Friess Thomas

  公开号：US20060063812A1

  公开（公告）日：2006-03-23

  The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, compositions containing such compounds and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.

  本发明涉及式I的化合物：它们的药用盐、对映体形式、二对映异构体和混合物，上述化合物的制备，含有这种化合物的组合物及其制备，以及这种化合物在控制或预防癌症等疾病中的应用。