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hexa-1,2,4-triene | 18231-57-7

分子结构分类

有机化合物 - 叠烯 - 无环联烯

中文名称

——

中文别名

——

英文名称

hexa-1,2,4-triene

英文别名

Hexa-1,2,4ξ-trien；Hexa-1,2,4-trien；Hexatrien-(1,2,4)；1,2,4-Hexatrien；Propenyl-allen

CAS

18231-57-7

化学式

C₆H₈

mdl

——

分子量

80.1295

InChiKey

NETPEWDFCPYQCU-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

计算性质

辛醇/水分配系数(LogP)：

1.7
重原子数：

6
可旋转键数：

1
环数：

0.0
sp3杂化的碳原子比例：

0.17
拓扑面积：

0
氢给体数：

0
氢受体数：

0

反应信息

作为反应物：

描述：

2-甲基-1-丁烯-3-酮、 hexa-1,2,4-triene 反应 2.0h，生成 1-(1,2-dimethyl-5-methylidenecyclohex-3-en-1-yl)ethanone

参考文献：

名称：

Bertrand,M. et al., Bulletin de la Societe Chimique de France, 1971, p. 962 - 973

摘要：

DOI：
作为产物：

描述：

(E)-己-4-烯-1-炔-3-醇在氢溴酸作用下，反应 0.02h，生成 hexa-1,2,4-triene

参考文献：

名称：

Dulcere,J.P. et al., Bulletin de la Societe Chimique de France, 1974, p. 1119 - 1123

摘要：

DOI：

点击查看最新优质反应信息

文献信息

A comparison of the efficacy of carbamazepine and the novel anti-epileptic drug levetiracetam in the tetanus toxin model of focal complex partial epilepsy

作者：H C Doheny、M A Whittington、J G R Jefferys、P N Patsalos

DOI：10.1038/sj.bjp.0704606

日期：2002.3

The tetanus toxin seizure model, which is associated with spontaneous and intermittent generalized and non‐generalized seizures, is considered to reflect human complex partial epilepsy. The purpose of the present study was to investigate and compare the anticonvulsant effects of carbamazepine with that of levetiracetam, a new anti‐epileptic drug in this model.

One μl of tetanus toxin solution (containing 12 mLD50 μl−1 of tetanus toxin) was placed stereotactically into the rat left hippocampus resulting in generalized and non‐generalized seizures. Carbamazepine (4 mg kg−1 h−1) and levetiracetam (8 and 16 mg kg−1 h−1) were administered during a 7 day period via an osmotic minipump which was placed in the peritoneal cavity.

Carbamazepine (4 mg kg−1 h−1) exhibited no significant anticonvulsant effect, compared to control, when the entire 7 day study period was evaluated but the reduction in generalized seizures was greater (35.5%) than that for non‐generalized seizures (12.6%). However, during the first 2 days of carbamazepine administration a significant reduction in both generalized seizure frequency (90%) and duration (25%) was observed. Non‐generalized seizures were unaffected. This time‐dependent anticonvulsant effect exactly paralleled the central (CSF) and peripheral (serum) kinetics of carbamazepine in that steady‐state concentrations declined over time, with the highest concentrations achieved during the first 2 days. Also there was a significant 27.3% reduction in duration of generalized seizures during the 7 day study period (P=0.0001).

Levetiracetam administration (8 and 16 mg kg−1 h−1) was associated with a dose‐dependent reduction in the frequency of both generalized (39 v 57%) and non‐generalized (36 v 41%) seizures. However, seizure suppression was more substantial for generalized seizures. Also a significant dose‐dependent reduction in overall generalized seizure duration was observed.

These data provide experimental evidence for the clinical efficacy of levetiracetam for the management of patients with complex partial seizures. Furthermore, levetiracetam probably does not act by preventing ictogenesis per se but acts to reduce seizure severity and seizure generalization.

British Journal of Pharmacology (2002) 135, 1425–1434; doi:10.1038/sj.bjp.0704606

项目号：DX-20231205-19 英/汉双语对照表翻译完毕。本次翻译由专业翻译公司提供服务。

Grimaldi,J. et al., Bulletin de la Societe Chimique de France, 1967, p. 2723 - 2728

作者：Grimaldi,J. et al.

DOI：——

日期：——

Dulcere,J.P. et al., Bulletin de la Societe Chimique de France, 1974, p. 1119 - 1123

作者：Dulcere,J.P. et al.

DOI：——

日期：——

Bertrand,M. et al., Bulletin de la Societe Chimique de France, 1971, p. 962 - 973

作者：Bertrand,M. et al.

DOI：——

日期：——

hexa-1,2,4-triene | 18231-57-7

分子结构分类

计算性质

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文献信息

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