3-bromomethyl-4'-chlorobenzophenone | 35278-62-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-bromomethyl-4'-chlorobenzophenone
• 英文别名: 3-(4-chloro-benzoyl)benzyl bromide；3-(4-chlorobenzoyl)benzyl bromide；[3-(bromomethyl)phenyl]-(4-chlorophenyl)methanone
• CAS: 35278-62-7
• 化学式: C₁₄H₁₀BrClO
• 分子量: 309.59
• InChiKey: YTHAPBSCSUJTLQ-UHFFFAOYSA-N

物化性质

• 沸点：
  417.4±35.0 °C(Predicted)
• 密度：
  1.481±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-bromomethyl-4'-chlorobenzophenone 以 1,4-二氧六环 、 水 为溶剂， 生成 3-p-chlorobenzoyl phenyl acetonitrile
  参考文献：
  名称：

  Novel benzoylphenylacetic acid esters

  摘要：

  盐酸苯甲酰基苯乙酸酯的外消旋体和光学活性异构体的制备方法，其中R选择自氢和1至7个碳原子的烷基组成的群，两个苯环可以选择性地与至少一种氯、氟、溴、三氟甲基、1至7个碳原子的烷基、烷氧基和烷硫基中的一种成员取代，以及它们作为止痛剂和抗炎药物的用途。

  公开号：

  US04192890A1
• 作为产物：
  描述：

  间甲基苯甲酸 在 N-溴代丁二酰亚胺(NBS) 、 三氯化铝 、 氯化亚砜 、 N,N-二甲基甲酰胺 、 过氧化苯甲酰 作用下， 以 苯 为溶剂， 反应 21.5h， 生成 3-bromomethyl-4'-chlorobenzophenone
  参考文献：
  名称：

  Bochis; Chabala; Harris, Journal of Medicinal Chemistry, 1991, vol. 34, # 9, p. 2843 - 2852

  摘要：

  DOI：

文献信息

• 4-(M-benzoylphenyl)butyric acid derivatives
  申请人：Roussel-UCLAF

  公开号：US03931302A1

  公开（公告）日：1976-01-06

  Novel butyric acid derivatives of the formula ##SPC1## Wherein X, X.sub.1, X.sub.2 and X.sub.3 are individually selected from the group consisting of hydrogen, halogen, lower alkyl of 1 to 5 carbon atoms, lower alkoxy of 1 to 5 carbon atoms, lower alkylthio of 1 to 5 carbon atoms, trifluoromethoxy, trifluoromethylthio, trifluoromethyl, OH and dilower alkylamino of 1 to 5 carbon atoms for each alkyl, R is selected from the group consisting of hydrogen, lower alkyl of 1 to 5 carbon atoms, o-carboxyphenyl, 2,3-dihydroxypropyl and -CH.sub.2 -CH - CH.sub.2 ##EQU1## wherein P and Q are individually lower alkyl of 1 to 5 carbon atoms, Z and X.sub.4 are individually selected from the group consisting of hydrogen and lower alkyl of 1 to 5 carbon atoms and Y is selected from the group consisting of hydrogen and --OH and the dotted line indicates the optional presence of a double bond when Y is hydrogen and when R is hydrogen or o-carboxyphenyl, the salts thereof with a non-toxic pharmaceutically acceptable mineral or organic base, which compounds have anti-inflammatory and analgesic activity and are substantially devoid of ulcerigenic activity and their preparation and novel intermediates formed therein.

  新型丁酸衍生物，其通式如##SPC1##所示，其中X、X₁、X₂和X₃各自独立地选自氢、卤素、含有1至5个碳原子的低级烷基、含有1至5个碳原子的低级烷氧基、含有1至5个碳原子的低级烷基硫基、三氟甲氧基、三氟甲基硫基、三氟甲基、羟基以及每个烷基含有1至5个碳原子的二低级烷基氨基；R选自氢、含有1至5个碳原子的低级烷基、邻羧基苯基、2,3-二羟基丙基以及-CH₂-CH-CH₂##EQU1##其中P和Q各自独立地为含有1至5个碳原子的低级烷基，Z和X₄各自独立地选自氢和含有1至5个碳原子的低级烷基，Y选自氢和--OH，虚线表示当Y为氢且R为氢或邻羧基苯基时可能存在的双键；与无毒的药用可接受的矿物或有机碱形成的盐，这些化合物具有抗炎和镇痛活性，且基本上无致溃疡活性，以及它们的制备方法和在其中形成的新型中间体。
• Heterocyclic compounds, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US05753664A1

  公开（公告）日：1998-05-19

  A novel compound of the formula: A--Z--Ar.sup.1 1'CO--Ar.sup.2 wherein A is a condensed pyrimidinone or condensed pyridazinone ring; Ar.sup.1 and Ar.sup.2 are independently a ring; Z is a divalent group, or a salt thereof which have an excellent antitumor activity.

  一种新的化合物，其化学式为：A--Z--Ar.sup.1 1'CO--Ar.sup.2，其中A是一个紧凑的嘧啶酮或紧凑的吡啶并酮环；Ar.sup.1和Ar.sup.2分别是一个环；Z是一个二价基团，或其盐，具有出色的抗肿瘤活性。
• 5-amino or substituted amino 1,2,3-triazoles
  申请人：Merck & Co., Inc.

  公开号：US04590201A1

  公开（公告）日：1986-05-20

  Novel 5-amino or substituted amino 1,2,3-triazoles are disclosed as having anticoccidial activity. The compounds are useful for controlling coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with animal sustenance.

  小说中披露了具有抗球虫活性的5-氨基或取代氨基1,2,3-三唑。这些化合物在与动物饲料混合后以微量给动物，特别是家禽，用于控制球虫病非常有效。
• Butyric acid derivatives for treating pain and inflammation
  申请人：Roussel-UCLAF

  公开号：US03995056A1

  公开（公告）日：1976-11-30

  Novel butyric acid derivatives of the formula ##SPC1## Wherein X, X.sub.1, X.sub.2 and X.sub.3 are individually selected from the group consisting of hydrogen, halogen, lower alkyl of 1 to 5 carbon atoms, lower alkoxy of 1 to 5 carbon atoms, lower alkylthio of 1 to 5 carbon atoms, trifluoromethoxy, trifluoromethylthio, trifluoromethyl, OH and dilower alkylamino of 1 to 5 carbon atoms for each alkyl, R is selected from the group consisting of hydrogen, lower alkyl of 1 to 5 carbon atoms, o-carboxyphenyl, 2,3-dihydroxypropyl and ##EQU1## wherein P and Q are individually lower alkyl of 1 to 5 carbon atoms, Z and X.sub.4 are individually selected from the group consisting of hydrogen and lower alkyl of 1 to 5 carbon atoms and Y is selected from the group consisting of hydrogen and --CH and the dotted line indicates the optional presence of a double bond when Y is hydrogen and when R is hydrogen or o-carboxyphenyl, the salts thereof with a non-toxic pharmaceutically acceptable mineral or orgaic base, which compounds have anti-inflammatory and analgesic activity and are substantially devoid of ulcerigenic activity and their preparation and novel intermediates formed therein.

  化合物的结构式为：##SPC1## 其中X，X.sub.1，X.sub.2和X.sub.3分别从氢，卤素，1至5个碳原子的低级烷基，1至5个碳原子的低级烷氧基，1至5个碳原子的低级烷硫基，三氟甲氧基，三氟甲基硫基，三氟甲基，OH和每个烷基的1至5个碳原子的二级烷胺中选择，而R从氢，1至5个碳原子的低级烷基，o-羧基苯基，2,3-二羟基丙基和##EQU1##中选择，其中P和Q分别是1至5个碳原子的低级烷基，Z和X.sub.4分别从氢和1至5个碳原子的低级烷基中选择，而Y从氢和--CH中选择，虚线表示当Y为氢时，当R为氢或o-羧基苯基时，存在一个可选的双键。这些化合物与无毒的药用矿物质或有机碱的盐具有抗炎和镇痛活性，并且基本上不具有溃疡原性活性，其制备和形成的新中间体。
• Allais; Rousseau; Meier, European Journal of Medicinal Chemistry, 1974, vol. 9, # 4, p. 381 - 389
  作者：Allais、Rousseau、Meier、et al.

  DOI：——

  日期：——