2-methyl-2-(trimethylsilyl-oxy)-glutaric acid dimethyl ester | 137051-86-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-methyl-2-(trimethylsilyl-oxy)-glutaric acid dimethyl ester
• 英文别名: Dimethyl 2-methyl-2-trimethylsilyloxypentanedioate
• CAS: 137051-86-6
• 化学式: C₁₁H₂₂O₅Si
• 分子量: 262.378
• InChiKey: KALAFLDTTMFZHS-UHFFFAOYSA-N

物化性质

• 沸点：
  278.5±30.0 °C(Predicted)
• 密度：
  1.012±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.72
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-methyl-2-(trimethylsilyl-oxy)-glutaric acid dimethyl ester 在 三甲基氯硅烷 、 sodium 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以73%的产率得到甲基环戊烯醇酮
  参考文献：
  名称：

  Synthesis of 2-Hydroxy-3-methyl-2-cyclo-pentenone, Corylone, from 2-Ketoglutaric Acid

  摘要：

  Treatment of 2-ketoglutaric acid with diazomethane gave 2-(methoxycarbonyl)-oxiranepropanoic acid methyl ester (2) which lead to 2-hydroxy-2-methyl-glutaric acid dimethyl ester (3) by catalytic hydrogenation, which was further processed to the title compound.

  DOI：

  10.1080/00397919108021577
• 作为产物：
  描述：

  alpha-酮戊二酸 在 palladium on activated charcoal 吡啶 、 氢气 、 六甲基二硅氮烷 作用下， 以 甲醇 、 乙醚 、 乙醇 为溶剂， 20.0 ℃ 、620.52 kPa 条件下， 反应 39.0h， 生成 2-methyl-2-(trimethylsilyl-oxy)-glutaric acid dimethyl ester
  参考文献：
  名称：

  Synthesis of 2-Hydroxy-3-methyl-2-cyclo-pentenone, Corylone, from 2-Ketoglutaric Acid

  摘要：

  Treatment of 2-ketoglutaric acid with diazomethane gave 2-(methoxycarbonyl)-oxiranepropanoic acid methyl ester (2) which lead to 2-hydroxy-2-methyl-glutaric acid dimethyl ester (3) by catalytic hydrogenation, which was further processed to the title compound.

  DOI：

  10.1080/00397919108021577

文献信息

• Synthesis of 2-Hydroxy-3-methyl-2-cyclo-pentenone, Corylone, from 2-Ketoglutaric Acid
  作者：Maria Lucília dos Santos、Gouvan C. de Magalhães

  DOI：10.1080/00397919108021577

  日期：1991.9

  Treatment of 2-ketoglutaric acid with diazomethane gave 2-(methoxycarbonyl)-oxiranepropanoic acid methyl ester (2) which lead to 2-hydroxy-2-methyl-glutaric acid dimethyl ester (3) by catalytic hydrogenation, which was further processed to the title compound.