Monofunctional Platinum Complexes Showing Potent Cytotoxicity against Human Liver Carcinoma Cell Line BEL-7402
作者:Junyong Zhang、Xiaoyong Wang、Chao Tu、Jun Lin、Jian Ding、Liping Lin、Zheming Wang、Cheng He、Chunhua Yan、Xiaozeng You、Zijian Guo
DOI:10.1021/jm020593j
日期:2003.7.1
Complex II crystallized in the monoclinic system with space group P2(1), a = 9.502(2) A, b = 4.724(1) A, c = 14.800(3) A, while complex III crystallized in the orthorhombic system with space group P2(1)2(1)2(1), a = 5.441(1) A, b = 12.978(3) A, c = 29.438(6) A. These complexes have been tested against a wide range of tumor cell lines including BEL-7402, HCT-116, SPC-A4, MOLT-4, P388, HL-60, A-549, SGC-7901
三个新型Pt(II)配合物[PtL(1)'Cl] I(L(1)'=甘氨酸-N'-8-喹啉酰胺),[PtL(2)'Cl] II(L(2)'= l -丙氨酸-N'-8-喹啉酰胺)和[PtL(3)Cl] III [L(3)= N-(叔丁氧基羰基)-1-蛋氨酸-N'-8-喹啉酰胺]的合成和表征。配合物II和III的晶体结构表明,配体是三配位的,只有一个Cl(-)作为离去基团。配合物II在具有空间群P2(1)的单斜晶系系统中结晶,a = 9.502(2)A,b = 4.724(1)A,c = 14.800(3)A,而配合物III在具有空间群的正交晶系中结晶。 P2(1)2(1)2(1),a = 5.441(1)A,b = 12.978(3)A,c = 29.438(6)A。这些复合物已针对多种肿瘤细胞系进行了测试包括BEL-7402,HCT-116,SPC-A4,MOLT-4,P388,HL-60,