5-(2-氨基噻唑-4-基)噻吩-2-腈 | 1414958-61-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 5-(2-氨基噻唑-4-基)噻吩-2-腈
• 英文名称: 5-(2-aminothiazol-4-yl)thiophene-2-carbonitrile
• 英文别名: 5-(2-Aminothiazol-4-yl)thiophene-2-carbonitrile；5-(2-amino-1,3-thiazol-4-yl)thiophene-2-carbonitrile
• CAS: 1414958-61-4
• 化学式: C₈H₅N₃S₂
• 分子量: 207.28
• InChiKey: JVOJRKACQXYOAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  119
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES
  申请人：Masarykova univerzita

  公开号：EP3556755A1

  公开（公告）日：2019-10-23

  The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.

  本发明提供了结构式（1）所代表的化合物： 其中 R1、R2、R3、R4、R5、R6 如权利要求中定义。这些化合物是核酸酶的抑制剂，特别适用于增殖性疾病、神经退行性疾病和其他基因组不稳定性相关疾病的治疗和/或预防方法。
• [EN] SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES<br/>[FR] AMINOTHIAZOLES SUBSTITUÉS UTILISÉS EN TANT QU'INHIBITEURS DE NUCLÉASES
  申请人：UNIV MASARYKOVA

  公开号：WO2019201865A1

  公开（公告）日：2019-10-24

  The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.