2-(4-methoxy-3-nitrobenzylsulfonyl)acetyl chloride | 1310065-00-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-methoxy-3-nitrobenzylsulfonyl)acetyl chloride
• 英文别名: 2-[(4-Methoxy-3-nitrophenyl)methylsulfonyl]acetyl chloride；2-[(4-methoxy-3-nitrophenyl)methylsulfonyl]acetyl chloride
• CAS: 1310065-00-9
• 化学式: C₁₀H₁₀ClNO₆S
• 分子量: 307.712
• InChiKey: CRIKTNKPECUIAG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  115
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-(4-methoxy-3-nitrobenzylsulfonyl)acetyl chloride 在 tin(ll) chloride 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 2-[(3-amino-4-methoxyphenyl)methylsulfonyl]-N-(2,4,6-trimethylphenyl)acetamide
  参考文献：
  名称：

  Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors

  摘要：

  We herein report the synthesis, biological activity and structure activity relationship of derivatives of benzylstyrylsulfone, benzylstyrylsulfine and benzylsulfonyl-N-phenylacetamide. A lead compound 7 represents a new class of mitotic inhibitors that demonstrates potent anti-proliferative activity and selectively induces cancer cell apoptosis while sparing non-transformed lung fibroblast. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.03.041
• 作为产物：
  描述：

  3-硝基-4-甲氧基苄溴 在 氯化亚砜 、 双氧水 、 sodium carbonate 作用下， 以 甲醇 、 溶剂黄146 、 乙酸乙酯 为溶剂， 反应 7.67h， 生成 2-(4-methoxy-3-nitrobenzylsulfonyl)acetyl chloride
  参考文献：
  名称：

  Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors

  摘要：

  We herein report the synthesis, biological activity and structure activity relationship of derivatives of benzylstyrylsulfone, benzylstyrylsulfine and benzylsulfonyl-N-phenylacetamide. A lead compound 7 represents a new class of mitotic inhibitors that demonstrates potent anti-proliferative activity and selectively induces cancer cell apoptosis while sparing non-transformed lung fibroblast. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.03.041

文献信息

• Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors
  作者：Osama Chahrour、Ashraf Abdalla、Frankie Lam、Carol Midgley、Shudong Wang

  DOI：10.1016/j.bmcl.2011.03.041

  日期：2011.5

  We herein report the synthesis, biological activity and structure activity relationship of derivatives of benzylstyrylsulfone, benzylstyrylsulfine and benzylsulfonyl-N-phenylacetamide. A lead compound 7 represents a new class of mitotic inhibitors that demonstrates potent anti-proliferative activity and selectively induces cancer cell apoptosis while sparing non-transformed lung fibroblast. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.