diethyl 3,6,9,12,15,18,21-heptaoxatricosanedioate | 1264440-24-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: diethyl 3,6,9,12,15,18,21-heptaoxatricosanedioate
• 英文别名: Diethyl 3,6,9,12,15,18,21-heptaoxatricosane-1,23-dioate；ethyl 2-[2-[2-[2-[2-[2-[2-(2-ethoxy-2-oxoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetate
• CAS: 1264440-24-5
• 化学式: C₂₀H₃₈O₁₁
• 分子量: 454.515
• InChiKey: MEVDQAAWPGPJLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  31
• 可旋转键数：
  26
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  117
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  diethyl 3,6,9,12,15,18,21-heptaoxatricosanedioate 在 肼 作用下， 以 甲醇 为溶剂， 反应 72.0h， 生成
  参考文献：
  名称：

  Bishydrazide Glycoconjugates for Lectin Recognition and Capture of Bacterial Pathogens

  摘要：

  Bishydrazides are versatile linkers for attaching glycans to substrates for lectin binding and pathogen detection schemes. The alpha,omega-bishydrazides of carboxymethylated hexa(ethylene glycol) (4) can be conjugated at one end to unprotected oligosaccharides, then attached onto carrier proteins, tethered onto activated carboxyl-terminated surfaces, or functionalized with a photoactive cross-linking agent for lithographic patterning. Glycoconjugates of bishydrazide 4 can also be converted into dithiocarbamates (DTCs) by treatment with CS2 under mild conditions, for attachment onto gold substrates. The immobilized glycans serve as recognition elements for cell-surface lectins and enable the detection and capture of bacterial pathogens such as Pseudomonas aeruginosa by their adsorption onto micropatterned substrates. A detection limit of 10(3) cfu/mL is demonstrated, using a recently introduced method based on optical pattern recognition.

  DOI：

  10.1021/bc100288c
• 作为产物：
  描述：

  六甘醇 、 溴乙酸乙酯 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 反应 20.5h， 以68%的产率得到diethyl 3,6,9,12,15,18,21-heptaoxatricosanedioate
  参考文献：
  名称：

  Pathogen detection

  摘要：

  病原体通过使用对突变具有抗性的配体来检测。

  公开号：

  US09250238B2

文献信息

• WO2024059665A1
  申请人：——

  公开号：——

  公开（公告）日：——
• Pathogen detection
  申请人：Low Philip S.

  公开号：US09250238B2

  公开（公告）日：2016-02-02

  Pathogens are detected through the use of mutation-resistant ligands.

  病原体通过使用对突变具有抗性的配体来检测。
• Bishydrazide Glycoconjugates for Lectin Recognition and Capture of Bacterial Pathogens
  作者：Avijit Kumar Adak、Alexei P. Leonov、Ning Ding、Jyothi Thundimadathil、Sumith Kularatne、Philip S. Low、Alexander Wei

  DOI：10.1021/bc100288c

  日期：2010.11.17

  Bishydrazides are versatile linkers for attaching glycans to substrates for lectin binding and pathogen detection schemes. The alpha,omega-bishydrazides of carboxymethylated hexa(ethylene glycol) (4) can be conjugated at one end to unprotected oligosaccharides, then attached onto carrier proteins, tethered onto activated carboxyl-terminated surfaces, or functionalized with a photoactive cross-linking agent for lithographic patterning. Glycoconjugates of bishydrazide 4 can also be converted into dithiocarbamates (DTCs) by treatment with CS2 under mild conditions, for attachment onto gold substrates. The immobilized glycans serve as recognition elements for cell-surface lectins and enable the detection and capture of bacterial pathogens such as Pseudomonas aeruginosa by their adsorption onto micropatterned substrates. A detection limit of 10(3) cfu/mL is demonstrated, using a recently introduced method based on optical pattern recognition.