bis[(2-methoxymethyloxy)phenyl]diselenide | 717106-99-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: bis[(2-methoxymethyloxy)phenyl]diselenide
• 英文别名: 1-(Methoxymethoxy)-2-[[2-(methoxymethoxy)phenyl]diselanyl]benzene；1-(methoxymethoxy)-2-[[2-(methoxymethoxy)phenyl]diselanyl]benzene
• CAS: 717106-99-5
• 化学式: C₁₆H₁₈O₄Se₂
• 分子量: 432.237
• InChiKey: YYJMHBSGPXOMCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.93
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  bis[(2-methoxymethyloxy)phenyl]diselenide 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 3.0h， 以81%的产率得到1,2-bis(2-hydroxyphenyl)diselenide
  参考文献：
  名称：

  Functionalized alkyl and aryl diselenides as antimicrobial and antiviral agents: synthesis and properties

  摘要：

  The different dialkyl and diaryl diselenides with carbamoyl and sulfamoyl moieties 2, 3, 5 and other substituents in the ortho position of benzene ring 4, 7, 8 as well as derivatives of 1,2,4-benzoselenadiazine (6) were designed as antiviral and antimicrobial agents and synthesized. Some of them, particularly 8a and 8b, were found in the antiviral assay in vitro to be strong inhibitors of cytopathic activity encephalomyocarditis virus (EMCV). The compound 4a and 8a were found to have a broad spectrum of acivity against bacteria, yeasts and pathogenic fungi in vitro.

  DOI：

  10.1016/j.farmac.2003.08.003
• 作为产物：
  描述：

  1-(甲氧基甲氧基)苯 在 正丁基锂 、 selenium 、 氧气 作用下， 生成 bis[(2-methoxymethyloxy)phenyl]diselenide
  参考文献：
  名称：

  Synthesis of novel organoselenium as catalyst for Baeyer–Villiger oxidation with 30% H2O2

  摘要：

  A novel diselenide was synthesized in good yield via only four steps from phenol, and was employed as the catalyst for the Baeyer-Villiger oxidation with 30% H2O2 to obtain lactones in good yields. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.10.055

文献信息

• Functionalized alkyl and aryl diselenides as antimicrobial and antiviral agents: synthesis and properties
  作者：H Wójtowicz、M Chojnacka、J Młochowski、J Palus、L Syper、D Hudecova、M Uher、E Piasecki、M Rybka

  DOI：10.1016/j.farmac.2003.08.003

  日期：2003.12

  The different dialkyl and diaryl diselenides with carbamoyl and sulfamoyl moieties 2, 3, 5 and other substituents in the ortho position of benzene ring 4, 7, 8 as well as derivatives of 1,2,4-benzoselenadiazine (6) were designed as antiviral and antimicrobial agents and synthesized. Some of them, particularly 8a and 8b, were found in the antiviral assay in vitro to be strong inhibitors of cytopathic activity encephalomyocarditis virus (EMCV). The compound 4a and 8a were found to have a broad spectrum of acivity against bacteria, yeasts and pathogenic fungi in vitro.
• Synthesis of novel organoselenium as catalyst for Baeyer–Villiger oxidation with 30% H2O2
  作者：Hayato Ichikawa、Yoshihide Usami、Masao Arimoto

  DOI：10.1016/j.tetlet.2005.10.055

  日期：2005.12

  A novel diselenide was synthesized in good yield via only four steps from phenol, and was employed as the catalyst for the Baeyer-Villiger oxidation with 30% H2O2 to obtain lactones in good yields. (c) 2005 Elsevier Ltd. All rights reserved.