FP-TMP | 2043338-91-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: FP-TMP
• 英文别名: fluoropropyl-TMP；Fptmp；5-[[4-(3-fluoropropoxy)-3,5-dimethoxyphenyl]methyl]pyrimidine-2,4-diamine
• CAS: 2043338-91-4
• 化学式: C₁₆H₂₁FN₄O₃
• 分子量: 336.366
• InChiKey: ZDPLXPQTCYRGBC-UHFFFAOYSA-N

物化性质

• 沸点：
  557.5±60.0 °C(Predicted)
• 密度：
  1.244±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  甲氧苄啶 在 氢溴酸 、 caesium carbonate 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.33h， 生成 FP-TMP
  参考文献：
  名称：

  [EN] RADIOTRACER DERIVATIVES OF TRIMETHOPRIM FOR DIAGNOSTIC IMAGING
  [FR] DÉRIVÉS RADIOINDICATEURS DE LA TRIMÉTHOPRIME POUR L'IMAGERIE DIAGNOSTIQUE

  摘要：

  本发明提供了用于影像检测（如PET扫描）的放射性标记的三甲嗪，这些化合物在体外显示出强大的细菌摄取，并在给予受试者时能够识别感染、炎症或肿瘤。这些化合物显示出对Ec DHFR含量肿瘤的快速和敏感检测，能够与对照肿瘤和背景组织区分开来。在一个方面，提供了具有结构式（I）的化合物或其药学上可接受的盐或前药，其中R在此处被定义。还提供了含有这些化合物的组合物，包括这些化合物的正电子发射断层扫描报告探针，以及用于影像细菌感染、追踪或监测细菌、区分细菌感染与炎症或肿瘤、监测基因融合蛋白表达以及监测临床场景中的基因工程细胞（如癌症治疗免疫治疗）的方法。

  公开号：

  WO2016183057A1

文献信息

• Radiotracer derivatives of trimethoprim for diagnostic imaging
  申请人：The Trustees of The University of Pennsylvania

  公开号：US10398790B2

  公开（公告）日：2019-09-03

  The present invention provides radiolabeled trimethoprim which are useful in imaging tests such as PET scans. The compounds show robust bacterial uptake in vitro and identify infections from inflammation or tumor when administered to a subject. The compounds show rapid and sensitive detection of Ec DHFR containing tumors from control tumors and background tissue. In one aspect, a compound having the structure of formula (I) is provided or a pharmaceutically acceptable salt or prodrug thereof, wherein R is defined herein. Also provided are compositions containing these compounds, positron emission tomography reporter probe comprising these compounds, and methods of imaging a bacterial infection, tracking or monitoring bacteria, distinguishing a bacterial infection from inflammation or tumor, monitoring genetically fused protein expression, and monitoring genetically engineered cells in clinical scenarios such as immunotherapy for cancer treatment.

  本发明提供了可用于 PET 扫描等成像检测的放射性标记三甲氧苄氨嘧啶。这些化合物在体外显示出强大的细菌吸收能力，并能在给受试者用药时识别炎症或肿瘤感染。这些化合物能从对照肿瘤和背景组织中快速灵敏地检测出含有 Ec DHFR 的肿瘤。在一个方面，提供了具有式（I）结构的化合物或其药学上可接受的盐或原药，其中 R 在此定义。此外，还提供了含有这些化合物的组合物、含有这些化合物的正电子发射断层扫描报告探针，以及细菌感染成像、跟踪或监测细菌、区分细菌感染与炎症或肿瘤、监测基因融合蛋白表达、监测临床应用（如癌症治疗的免疫疗法）中基因工程细胞的方法。
• RADIOTRACER DERIVATIVES OF TRIMETHOPRIM FOR DIAGNOSTIC IMAGING
  申请人：The Trustees of The University of Pennsylvania

  公开号：EP3294291B1

  公开（公告）日：2021-01-13
• RADIOTRACER DERIVATIVES OF TRIMETHOPRIM FOR DIAGNOSITC IMAGING
  申请人：The Trustees of The University of Pennsylvania

  公开号：US20180104365A1

  公开（公告）日：2018-04-19

  The present invention provides radiolabeled trimethoprim which are useful in imaging tests such as PET scans. The compounds show robust bacterial uptake in vitro and identify infections from inflammation or tumor when administered to a subject. The compounds show rapid and sensitive detection of Ec DHFR containing tumors from control tumors and background tissue. In one aspect, a compound having the structure of formula (I) is provided or a pharmaceutically acceptable salt or prodrug thereof, wherein R is defined herein. Also provided are compositions containing these compounds, positron emission tomography reporter probe comprising these compounds, and methods of imaging a bacterial infection, tracking or monitoring bacteria, distinguishing a bacterial infection from inflammation or tumor, monitoring genetically fused protein expression, and monitoring genetically engineered cells in clinical scenarios such as immunotherapy for cancer treatment.
• Compositions And Methods For Imaging Immune Cells
  申请人：The Trustees of the University of Pennsylvania

  公开号：US20200316231A1

  公开（公告）日：2020-10-08

  The present disclosure provides immunes cells comprising a radiolabeled tracer useful in imaging tests such as positron emission topography (PET)/computed tomography (CT) scans. The present disclosure further includes engineered cells comprising a chimeric antigen receptor (CAR) further comprising a nucleic acid molecule comprising a ligand binding domain capable of binding to radiolabeled tracer. This disclosure also includes methods for assessing the efficacy or toxicity of an adoptive cell therapy in a subject, methods for detecting the quantity of engineered T cells in a subject, methods for monitoring an immunotherapy treatment in a subject and methods of imaging engineered T cells in a subject. In some embodiments, the radiolabeled tracer is [ 18 F]fluoropropyl-trimethoprim ([ 18 F]FPTMP).
• Radiotracer Derivatives Of Trimethoprim For Diagnostic Imaging
  申请人：The Trustees of the University of Pennsylvania

  公开号：US20210138093A1

  公开（公告）日：2021-05-13

  The present invention provides radiolabeled trimethoprim which are useful in imaging tests such as PET scans. The compounds show robust bacterial uptake in vitro and identify infections from inflammation or tumor when administered to a subject. The compounds show rapid and sensitive detection of Ec DHFR containing tumors from control tumors and background tissue. In one aspect, a compound having the structure of formula (I) is provided or a pharmaceutically acceptable salt or prodrug thereof, wherein R is defined herein. Also provided are compositions containing these compounds, positron emission tomography reporter probe comprising these compounds, and methods of imaging a bacterial infection, tracking or monitoring bacteria, distinguishing a bacterial infection from inflammation or tumor, monitoring genetically fused protein expression, and monitoring genetically engineered cells in clinical scenarios such as immunotherapy for cancer treatment.