(E)-12-Oxooctadec-9-enoic Acid | 6629-55-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-12-Oxooctadec-9-enoic Acid
• 英文别名: 12-oxo-9E-octadecenoic acid；12-oxooctadec-9-enoic acid；12-oxo-octadec-9t-enoic acid；12-Oxo-octadec-9t-ensaeure
• CAS: 6629-55-6
• 化学式: C₁₈H₃₂O₃
• 分子量: 296.45
• InChiKey: QHEOVCWNVASAFS-FMIVXFBMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  21
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (E)-12-Oxooctadec-9-enoic Acid 生成 12-oxo-octadec-trans-10-enoic acid
  参考文献：
  名称：

  297.反式-11- oxoheptadec-9-ene-1-羧酸和反式-11- oxoheptadec-8-ene-1-羧酸（12-氧杂苯甲酸）的自氧化作用，以及对莱胶酸的自氧化作用的一些观察结果

  摘要：

  DOI：

  10.1039/jr9580001485
• 作为产物：
  描述：

  ricinelaidic acid 在 chromium(VI) oxide 、 溶剂黄146 作用下， 生成 (E)-12-Oxooctadec-9-enoic Acid
  参考文献：
  名称：

  Keto Fatty Acids Derived from Castor Oil. II. Epoxy and Hydroxy Acids^1,2

  摘要：

  DOI：

  10.1021/ja01554a034

文献信息

• Elongation of the Hydrophobic Chain as a Molecular Switch: Discovery of Capsaicin Derivatives and Endogenous Lipids as Potent Transient Receptor Potential Vanilloid Channel 2 Antagonists
  作者：Aniello Schiano Moriello、Silvia López Chinarro、Olalla Novo Fernández、Jordi Eras、Pietro Amodeo、Ramon Canela-Garayoa、Rosa Maria Vitale、Vincenzo Di Marzo、Luciano De Petrocellis

  DOI：10.1021/acs.jmedchem.8b00734

  日期：2018.9.27

  potent pharmacological tools and endogenous modulators. Here we describe the discovery of novel synthetic long-chain capsaicin derivatives as potent TRPV2 antagonists in comparison to the totally inactive capsaicin, the role of their hydrophobic chain, and how the structure–activity relationships of such derivatives led, through a ligand-based approach, to the identification of endogenous long-chain

  瞬时受体电位香草2型（TRPV2）蛋白是非选择性Ca 2+由于缺乏可用的选择性和有效的药理学工具和内源性调节剂，TRPV亚家族的可渗透通道成员仍被认为是孤立的TRP通道。在这里，我们描述了通过完全基于配体的方法发现的新型合成长链辣椒素衍生物作为强效TRPV2拮抗剂（与完全无活性的辣椒素相比），它们的疏水链的作用以及这些衍生物的结构-活性关系如何导致的发现。 ，以鉴定充当TRPV2拮抗剂的内源性长链脂肪酸乙醇酰胺或伯酰胺。合成的和内源性的拮抗剂都表现出对以不同的动力学特征为特征的已知TRPV2激动剂的不同抑制作用。
• METHOD FOR PRODUCING MEDIUM-CHAIN OMEGA-HYDROXY FATTY ACIDS, ALPHA,OMEGA-DICARBOXYLIC ACIDS, AND OMEGA-AMINO FATTY ACIDS FROM LONG-CHAIN FATTY ACIDS BY BIOTRANSFORMATION
  申请人：EHWA UNIVERSITY - UNIVERSITY COLLABORATION FOUNDATION

  公开号：US20150057461A1

  公开（公告）日：2015-02-26

  The present invention relates to a transformant which is transformed to express Baeyer-Villiger monooxygenase (BVMO), a method for producing C5-C14 medium-chain ω-hydroxy fatty acids, α,ω-dicarboxylic acids, ω-amino fatty acids, or alcohols from C16-C20 long-chain fatty acids by biotransformation using the transformant, a method for producing a fatty acid derivative having an ester group which is introduced into the chain thereof from keto fatty acid using the BVMO, and novel ω-hydroxy fatty acids which are prepared by the method. Degradation products such as C5 to C14 ω-hydroxy fatty acids, α,ω-dicarboxylic acids, ω-amino fatty acids, alcohols can be produced in a large amount from C16 to C20 long-chain fatty acids contained in a medium by biotransformation using a transformant capable of expressing BVMO of the present invention. Therefore, it can be widely used to produce ω-hydroxy fatty acids, α,ω-dicarboxylic acids, ω-amino fatty acids or alcohols in a more safe and economic manner.

  本发明涉及一种转化体，该转化体被转化以表达Baeyer-Villiger单加氧酶（BVMO），以及通过使用该转化体进行生物转化从C16-C20长链脂肪酸中生产C5-C14中链ω-羟基脂肪酸、α，ω-二羧酸、ω-氨基脂肪酸或醇的方法，以及使用BVMO从酮脂肪酸中引入酯基的脂肪酸衍生物的制备方法和新的ω-羟基脂肪酸。通过使用本发明的能够表达BVMO的转化体进行生物转化，可以从介质中含有的C16到C20长链脂肪酸中大量生产C5到C14的ω-羟基脂肪酸、α，ω-二羧酸、ω-氨基脂肪酸、醇等降解产物。因此，它可以广泛用于更安全、更经济地生产ω-羟基脂肪酸、α，ω-二羧酸、ω-氨基脂肪酸或醇。
• Codon-optimized epoxygenases / hydroxylases
  申请人：Divergence, Inc.

  公开号：EP2182062A2

  公开（公告）日：2010-05-05

  The present invention provides DNA constructs, transgenic plants containing such constructs, and methods of making the plants. The DNA constructs encode a polypeptide that when expressed results in the production of fatty acid compounds having anthelmintic activity. Transgenic plants expressing such a polypeptide can exhibit enhanced resistance to plant parasitic nematodes, particularly when expressed in vegetative tissues. Transgenic plants expressing such a polypeptide can also be useful for non-pesticidal industrial uses.

  本发明提供了 DNA 构建体、含有这种构建体的转基因植物以及制造这种植物的方法。DNA 构建体编码一种多肽，该多肽表达后可产生具有驱虫活性的脂肪酸化合物。表达这种多肽的转基因植物对植物寄生线虫的抗性增强，尤其是在无性组织中表达时。表达这种多肽的转基因植物还可用于非杀虫工业用途。
• METHOD FOR PRODUCING MIDDLE-CHAIN OMEGA-HYDROXY FATTY ACIDS, ALPHA AND OMEGA-DICARBOXYLIC ACIDS, AND OMEGA-AMINO FATTY ACIDS FROM LONG-CHAIN FATTY ACIDS BY BIOTRANSFORMATION
  申请人：Ewha University-Industry Collaboration Foundation

  公开号：EP2835425A1

  公开（公告）日：2015-02-11

  The present invention relates to a transformant which is transformed to express Baeyer-Villiger monooxygenase (BVMO), a method for producing C5-C14 medium-chain ω-hydroxy fatty acids, α,ω-dicarboxylic acids, ω-amino fatty acids, or alcohols from C16-C20 long-chain fatty acids by biotransformation using the transformant, a method for producing a fatty acid derivative having an ester group which is introduced into the chain thereof from keto fatty acid using the BVMO, and novel ω-hydroxy fatty acids which are prepared by the method. Degradation products such as C5 to C14 ω-hydroxy fatty acids, α,ω-dicarboxylic acids, ω-amino fatty acids, alcohols can be produced in a large amount from C16 to C20 long-chain fatty acids contained in a medium by biotransformation using a transformant capable of expressing BVMO of the present invention. Therefore, it can be widely used to produce ω-hydroxy fatty acids, α,ω-dicarboxylic acids, ω-amino fatty acids or alcohols in a more safe and economic manner.

  本发明涉及一种经转化表达拜耳-维利格单加氧酶（BVMO）的转化体，一种利用转化体通过生物转化从C16-C20长链脂肪酸生产C5-C14中链ω-羟基脂肪酸、α，ω-二羧酸、ω-氨基脂肪酸或醇的方法，一种利用转化体从酮脂肪酸生产具有酯基的脂肪酸衍生物的方法、一种利用 BVMO 生产具有酯基的脂肪酸衍生物的方法，该酯基是利用 BVMO 从酮脂肪酸引入其链中的；以及一种利用该方法制备新型ω-羟基脂肪酸的方法。利用能表达本发明 BVMO 的转化体进行生物转化，可从培养基中所含的 C16 至 C20 长链脂肪酸中产生大量降解产物，如 C5 至 C14 ω-羟基脂肪酸、α,ω-二羧酸、ω-氨基脂肪酸、醇类。因此，它可广泛用于以更安全、更经济的方式生产ω-羟基脂肪酸、α,ω-二羧酸、ω-氨基脂肪酸或醇。
• ANTI-INFLAMMATORY AGENT CONTAINING RARE FATTY ACID
  申请人：Kyoto University

  公开号：EP3097910A1

  公开（公告）日：2016-11-30

  The present invention provides an anti-inflammatory agent containing a rare fatty acid such as hydroxylated fatty acid, oxo fatty acid and the like, and further, food, pharmaceutical product and the like containing the anti-inflammatory agent.

  本发明提供了一种含有稀有脂肪酸（如羟化脂肪酸、氧代脂肪酸等）的消炎剂，以及含有该消炎剂的食品、药品等。