(E,E)-1,5-bis[4-(diethylamino)phenyl]penta-1,4-dien-3-one | 61445-93-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E,E)-1,5-bis[4-(diethylamino)phenyl]penta-1,4-dien-3-one
• 英文别名: 1,5-bis[4-(diethylamino)phenyl]-1,4-pentadien-3-one；1,5-bis[4-(diethylamino)phenyl]penta-1,4-dien-3-one；(1E,4E)-1,5-bis(4-(diethylamino)phenyl)penta-1,4-dien-3-one；1t,5t-bis-(4-diethylamino-phenyl)-penta-1,4-dien-3-one；1t,5t-Bis-(4-diaethylamino-phenyl)-penta-1,4-dien-3-on；(1E,4E)-1,5-bis[4-(diethylamino)phenyl]penta-1,4-dien-3-one
• CAS: 61445-93-0
• 化学式: C₂₅H₃₂N₂O
• 分子量: 376.542
• InChiKey: ZNNRTWIXUUGIFI-IWGRKNQJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (E)-methyl 3-(1-(4-methoxybenzyl)-2,3-dioxoindolin-5-yl)acrylate 、 (E,E)-1,5-bis[4-(diethylamino)phenyl]penta-1,4-dien-3-one 、 L-噻唑烷-4-羧酸 以 甲醇 为溶剂， 反应 4.0h， 以88%的产率得到methyl (E)-3-(7'-(4-(diethylamino)phenyl)-6'-((E)-3-(4-(diethylamino)phenyl)acryloyl)-1-(4-m-ethoxybenzyl)-2-oxo-1',6',7',7a'-tetrahydro-3'H-spiro[indoline-3,5'-pyrrolo[1,2-c]thiazol]-5-yl)acrylate
  参考文献：
  名称：

  四环羟吲哚的合成及其对α-葡萄糖苷酶的抑制和葡萄糖消耗促进活性的评估。

  摘要：

  通过不对称的1、3-偶极反应分2-4个步骤合成了一系列四环羟吲哚衍生物，总产率为57-86％。评价了这些化合物在体外的α-葡萄糖苷酶抑制作用和促进葡萄糖消耗的活性。化合物4l具有竞争性和可逆性地抑制α-葡萄糖苷酶（IC 50 = 3.64μM），其活性比阿卡波糖高14倍。对接分析证实了这些发现。另外，化合物4l在1μM处表现出显着的促进葡萄糖消耗的活性。

  DOI：

  10.1016/j.bmcl.2020.127264
• 作为产物：
  描述：

  N,N-二乙基-4-氨基苯甲醛 、 丙酮 在 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 4.0h， 生成 (E,E)-1,5-bis[4-(diethylamino)phenyl]penta-1,4-dien-3-one
  参考文献：
  名称：

  四环羟吲哚的合成及其对α-葡萄糖苷酶的抑制和葡萄糖消耗促进活性的评估。

  摘要：

  通过不对称的1、3-偶极反应分2-4个步骤合成了一系列四环羟吲哚衍生物，总产率为57-86％。评价了这些化合物在体外的α-葡萄糖苷酶抑制作用和促进葡萄糖消耗的活性。化合物4l具有竞争性和可逆性地抑制α-葡萄糖苷酶（IC 50 = 3.64μM），其活性比阿卡波糖高14倍。对接分析证实了这些发现。另外，化合物4l在1μM处表现出显着的促进葡萄糖消耗的活性。

  DOI：

  10.1016/j.bmcl.2020.127264

文献信息

• Analogs of Michler’s ketone for two-photon absorption initiation of polymerization in the near infrared: synthesis and photophysical properties
  作者：Gilles Lemercier、Cécile Martineau、Jean-Christophe Mulatier、Irène Wang、Olivier Stéphan、Patrice Baldeck、Chantal Andraud

  DOI：10.1039/b608391a

  日期：——

  We present the synthesis of substituted ketones, conjugated analogs of Michler’s ketone. These molecules exhibit broadband TPA properties between 700 and 1100 nm due to a charge transfer from the terminal amino groups to the central ketone function and with maximum cross sections from 200 to 325 × 10−50 cm4 s photon−1. Moreover, they present an interesting reducing character for radical creation. Both properties allow us to consider these molecules as promising photoinitiators of polymerization in the near infrared.

  我们合成了取代酮--Michler酮的共轭类似物。由于电荷从末端氨基转移到中心酮功能，这些分子在 700 至 1100 纳米波长范围内表现出宽带 TPA 特性，最大截面为 200 至 325 Ã 10â50 cm4 s 光子1。此外，它们还能产生有趣的还原性自由基。这两种特性使我们能够将这些分子视为有前景的近红外聚合光引发剂。
• Binder-mixtures for optical recording layers and elements
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0118881A2

  公开（公告）日：1984-09-19

  A solid, nonpolymeric amorphous mixture of compounds which is useful as a binder in optical recording elements is disclosed. The mixture comprises at least two different compounds each having at least two linking groups joining one multivalent organic nucleus with at least two organic nuclei wherein at least one of the multivalent organic nucleus and the organic nuclei is multicyclic. Methods for making such mixtures are also disclosed.

  本发明公开了一种固态非聚合无定形混合物，可用作光学记录元件的粘合剂。该混合物包括至少两种不同的化合物，每种化合物至少有两个连接基团，连接一个多价有机核和至少两个有机核，其中多价有机核和有机核中至少有一个是多环的。还公开了制造这种混合物的方法。
• Curable composition
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0203393A1

  公开（公告）日：1986-12-03

  A curable composition comprising (a) a curable polyimide soluble in organic solvents and (b) a polymerization initiator as essential components, said polyimide consisting of recurring units represented by the formula wherein, each of X, X1, X2, X3 and X4 is a tetravalent carbocyclic or heterocyclic residue, each of Y1, Y2 and Y3 is a divalent carbocyclic or heterocyclic residue, at least one of Z1 and Z2 is a residue having a reactive carbon-carbon double bond, and each of I, m, and n is an integer of 0 or larger.

  一种可固化组合物，包括(a)可溶于有机溶剂的可固化聚酰亚胺和(b)作为基本成分的聚合引发剂，所述聚酰亚胺由由式表示的递归单元组成 其中，X、X1、X2、X3 和 X4 中的每一个是四价碳环或杂环残基，Y1、Y2 和 Y3 中的每一个是二价碳环或杂环残基，Z1 和 Z2 中的至少一个是具有活性碳碳双键的残基，I、m 和 n 中的每一个是 0 或更大的整数。
• A precursor of a low thermal stress polyimide and a photopolymerizable composition containing a polyimide precursor
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0355927A2

  公开（公告）日：1990-02-28

  Disclosed is a polyimide precursor comprising a specific polyamic acid ester, polyamic amide or polyamic acid salt structure derived from a tetracarboxylic acid compound and a diamine compound, which can be converted by heating to a polyimide having low thermal stress. By blending a specific form of this novel polyimide precursor which has an ethylenic double bond, with a photopolymerization initiator, an excellent photopolymerizable composition can be obtained. Not only this precursor but also the crosslinked precursor obtained by the photopolymerization of the photopolymerizable composition can be converted by heating to a polyimide resin which has low thermal expansion coefficient, high heat resistance, excellent mechanical properties and satisfactory adhesion to a substrate. Hence, the precursor and the photopolymerizable composition can advantageously be utilized in the production of electrical and electronic components.

  本发明公开了一种聚酰亚胺前体，它由特定的聚酰胺酸酯、聚酰胺或聚酰胺酸盐结构组成，由四羧酸化合物和二胺化合物衍生而成，可通过加热转化为具有低热应力的聚酰亚胺。将这种具有乙烯双键的新型聚酰亚胺前体的特定形式与光聚合引发剂混合，可以得到一种极佳的光聚合组合物。不仅是这种前体，通过光聚合反应得到的交联前体也可以通过加热转化为聚酰亚胺树脂，这种树脂具有低热膨胀系数、高耐热性、优异的机械性能以及与基材的良好粘合性。因此，这种前体和可光聚合组合物可以很好地用于电气和电子元件的生产。
• Photosensitive resin composition and semiconductor apparatus using it
  申请人：SUMITOMO BAKELITE COMPANY LIMITED

  公开号：EP0430220A2

  公开（公告）日：1991-06-05

  The present invention provides a photosensitive resin composition which comprises as essential components: (A) a polyamic acid having a recurring unit represented by the following formula [I]: wherein 0.5-50 mol% of R₁ consists of a silicone diamine residue represented by the following formula [II]: wherein n represents an integer of 1-50, and the remainder of 50-99.5 mol% of R₁ consists of an organic group selected from the group consisting of an aromatic group, an aliphatic group, an alicyclic group, and a heterocyclic group, and R₂ consists of an organic group selected from the group consisting of an aromatic group, an aliphatic group, an alicyclic group, a heterocyclic group, and a silicone group, and m represents 1 or 2, (B) an amide compound having carbon-carbon double bond, and (C) a photosensitizer. The present invention further provides a semiconductor apparatus in which the above composition is used.

  本发明提供了一种光敏树脂组合物，其主要成分包括 (A) 具有下式[I]代表的递归单元的聚酰胺酸： 其中0.5-50 摩尔%的R₁由下式[II]代表的有机硅二胺残基组成： 其中n代表1-50的整数，其余50-99.5 mol％的R₁由选自芳香族基团、脂肪族基团、脂环族基团和杂环族基团的有机基团组成，R₂由选自芳香族基团、脂肪族基团、脂环族基团、杂环族基团和硅酮基团的有机基团组成，m代表1或2、 (B) 具有碳碳双键的酰胺化合物，和 (C) 一种光敏剂。 本发明进一步提供了一种使用上述组合物的半导体装置。