nikkomycin Z hydrochloride | 1419611-26-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: nikkomycin Z hydrochloride
• 英文别名: Nikkomycin z hydrochloride；(2S)-2-[[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino]-2-[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]acetic acid;hydrochloride
• CAS: 1419611-26-9
• 化学式: C₂₀H₂₅N₅O₁₀*ClH
• 分子量: 531.907
• InChiKey: HLFYQXGEGXXXIQ-FNRJKXLQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.06
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  245
• 氢给体数：
  9
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  华光霉素 在 盐酸 作用下， 以 水 为溶剂， 生成 nikkomycin Z hydrochloride
  参考文献：
  名称：

  A Practical and Scalable Manufacturing Process for an Antifungal Agent, Nikkomycin Z

  摘要：

  A scalable and reliable manufacturing process for nikkomycin Z HCl on a scale of 170 g has been developed and optimized. The process is characterized by a 2.3 g/L fermentation yield, 79% purification yield, and >98% relative purity of the final product. This method is suitable for further scale-up and cGMP production. The Streptomyces tendae Delta NikQ strain developed during the course of this study is superior to any previously reported strain in terms of higher yield and purity of nikkomycin Z.

  DOI：

  10.1021/op3003294

文献信息

• A Practical and Scalable Manufacturing Process for an Antifungal Agent, Nikkomycin Z
  作者：Christopher J. Stenland、Lev G. Lis、Frederick J. Schendel、Nicholas J. Hahn、Mary A. Smart、Amy L. Miller、Marc G. von Keitz、Vadim J. Gurvich

  DOI：10.1021/op3003294

  日期：2013.2.15

  A scalable and reliable manufacturing process for nikkomycin Z HCl on a scale of 170 g has been developed and optimized. The process is characterized by a 2.3 g/L fermentation yield, 79% purification yield, and >98% relative purity of the final product. This method is suitable for further scale-up and cGMP production. The Streptomyces tendae Delta NikQ strain developed during the course of this study is superior to any previously reported strain in terms of higher yield and purity of nikkomycin Z.