neopentyl ((naphthalen-1-yloxy)(perfluorophenoxy)phosphoryl)-L-alaninate | 1392015-40-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: neopentyl ((naphthalen-1-yloxy)(perfluorophenoxy)phosphoryl)-L-alaninate
• 英文别名: (2S)-neopentyl 2-(((naphthalen-1-yloxy)(perfluorophenoxy)phosphoryl)amino)propanoate；2,2-dimethylpropyl (2S)-2-[[naphthalen-1-yloxy-(2,3,4,5,6-pentafluorophenoxy)phosphoryl]amino]propanoate
• CAS: 1392015-40-5
• 化学式: C₂₄H₂₃F₅NO₅P
• 分子量: 531.416
• InChiKey: NDIBBBSETUDPIO-JWFSFFBCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  73.9
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  瑞德西韦母核 、 neopentyl ((naphthalen-1-yloxy)(perfluorophenoxy)phosphoryl)-L-alaninate 在 叔丁基氯化镁 作用下， 以 四氢呋喃 为溶剂， 以21.6 %的产率得到neopentyl ((((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)phosphoryl)-L-alaninate
  参考文献：
  名称：

  [EN] ANTIVIRAL PRODRUGS AND FORMULATIONS THEREOF
  [FR] PROMÉDICAMENTS ANTIVIRAUX ET FORMULATIONS CORRESPONDANTES

  摘要：

  Provided herein are compounds of Formula (I) as disclosed herein, pharmaceutical compositions comprising said compounds, and methods of using said compounds for the treatment and/or prevention of various viral infections, such as SARS-CoV-2 infections.

  公开号：

  WO2023102472A1
• 作为产物：
  描述：

  (S)-neopentyl 2-((tert-butoxycarbonyl)amino)propanoate 在 盐酸 、 三乙胺 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 21.0h， 生成 neopentyl ((naphthalen-1-yloxy)(perfluorophenoxy)phosphoryl)-L-alaninate
  参考文献：
  名称：

  [EN] ANTIVIRAL PRODRUGS AND FORMULATIONS THEREOF
  [FR] PROMÉDICAMENTS ANTIVIRAUX ET FORMULATIONS CORRESPONDANTES

  摘要：

  Provided herein are compounds of Formula (I) as disclosed herein, pharmaceutical compositions comprising said compounds, and methods of using said compounds for the treatment and/or prevention of various viral infections, such as SARS-CoV-2 infections.

  公开号：

  WO2023102472A1

文献信息

• 2'-CYANO SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF USEFUL FOR THE TREATMENT OF VIRAL DISEASES
  申请人：Girijavallabhan Vinay

  公开号：US20140161770A1

  公开（公告）日：2014-06-12

  The present invention relates to 2′-Cyano Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R 1 , R 2 and R 3 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Cyano Substituted Nucleoside Derivative, and methods of using the 2′-Cyano Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.

  本发明涉及式(I)的2'-氰基取代核苷衍生物及其药学上可接受的盐，其中B、X、R1、R2和R3如本文所定义。本发明还涉及包含至少一种2'-氰基取代核苷衍生物的组合物，以及使用这些2'-氰基取代核苷衍生物治疗或预防患者HCV感染的方法。
• STEREOSELECTIVE SYNTHESIS OF PHOSPHORUS CONTAINING ACTIVES
  申请人：ROSS BRUCE S.

  公开号：US20110245484A1

  公开（公告）日：2011-10-06

  Disclosed herein are phosphorus-containing actives, their use as actives for treating diseases, and a stereoselective process for preparing the same. Also disclosed herein are useful synthetic intermediates and processes for preparing the same.

  本文披露了含磷活性物质，其作为治疗疾病的活性物质的用途，以及用于制备它们的立体选择性过程。本文还披露了有用的合成中间体和制备它们的过程。
• Stereoselective synthesis of phosphorus containing actives
  申请人：Ross Bruce S.

  公开号：US08859756B2

  公开（公告）日：2014-10-14

  Disclosed herein are phosphorus-containing actives, their use as actives for treating diseases, and a stereoselective process for preparing the same. Also disclosed herein are useful synthetic intermediates and processes for preparing the same.

  本文披露了含磷活性物质，它们作为治疗疾病的活性物质的用途，以及用于制备它们的立体选择性过程。本文还披露了有用的合成中间体和制备它们的过程。
• 2'-CYANO SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2696679B1

  公开（公告）日：2017-08-02
• US9150603B2
  申请人：——

  公开号：US9150603B2

  公开（公告）日：2015-10-06