benzyliminodimethanol | 882697-72-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyliminodimethanol
• 英文别名: [Benzyl(hydroxymethyl)amino]methanol
• CAS: 882697-72-5
• 化学式: C₉H₁₃NO₂
• 分子量: 167.208
• InChiKey: WEVYFDFIBRNHBE-UHFFFAOYSA-N

物化性质

• 沸点：
  275.5±30.0 °C(Predicted)
• 密度：
  1.185±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  benzyliminodimethanol 、 10-羟基喜树碱 以 1,4-二氧六环 为溶剂， 反应 10.0h， 生成 (18S)-6-benzyl-18-ethyl-18-hydroxy-8,20-dioxa-6,13,24-triazahexacyclo[12.11.0.03,12.04,9.015,24.017,22]pentacosa-1,3(12),4(9),10,13,15,17(22)-heptaene-19,23-dione
  参考文献：
  名称：

  新型六环喜树碱衍生物。第1部分：带有A环稠合的1,3-恶嗪环的喜树碱的合成和细胞毒性。

  摘要：

  首先设计并合成了一系列新的含有1，3-恶嗪环的A环修饰的六环喜树碱衍生物。分析了所有六环喜树碱对九种人类癌细胞系的体外细胞毒性。在这些化合物中，9b和9c对几种细胞系表现出最强的细胞毒性。特别地，对于HEPG-2，9c的效力比喜树碱强约13倍，并且比拓扑替康强约六倍。此外，还发现对于大多数细胞系，N-烷基取代的衍生物比N-芳基和N-苄基取代的化合物更有效。

  DOI：

  10.1016/j.bmcl.2008.05.103
• 作为产物：
  描述：

  聚合甲醛 、 苄胺 以 1,4-二氧六环 为溶剂， 反应 2.0h， 生成 benzyliminodimethanol
  参考文献：
  名称：

  新型六环喜树碱衍生物。第1部分：带有A环稠合的1,3-恶嗪环的喜树碱的合成和细胞毒性。

  摘要：

  首先设计并合成了一系列新的含有1，3-恶嗪环的A环修饰的六环喜树碱衍生物。分析了所有六环喜树碱对九种人类癌细胞系的体外细胞毒性。在这些化合物中，9b和9c对几种细胞系表现出最强的细胞毒性。特别地，对于HEPG-2，9c的效力比喜树碱强约13倍，并且比拓扑替康强约六倍。此外，还发现对于大多数细胞系，N-烷基取代的衍生物比N-芳基和N-苄基取代的化合物更有效。

  DOI：

  10.1016/j.bmcl.2008.05.103

文献信息

• An [Fe-Fe]-Hydrogenase Mimic Immobilized on MCM-41 for the Photochemical Production of Hydrogen in Pure Water
  作者：Wen Wang、Tianjun Yu、Yi Zeng、Jinping Chen、Yi Li

  DOI：10.1002/cjoc.201400083

  日期：2014.6

  hydrophobic [Fe‐Fe]‐hydrogenase mimic (Hy) incorporated into the K+‐exchanged molecular sieve MCM‐41. Hy acts as the active site to generate H2 by reducing H+, and MCM‐41 provide a large surface area to maintain the dispersion of Hy and to prevent aggregation and precipitation. Hy@MCM‐41 was successfully applied to the light‐induced hydrogen production in pure water with an iridium compound [Ir(ppy)2bpy]Cl

  通过将疏水的[Fe-Fe]-氢化酶模拟物（Hy）掺入K +交换分子筛MCM-41中，制得了复合质子还原催化剂Hy @ MCM-41。Hy充当通过还原H +生成H 2的活性位点，MCM-41提供大的表面积以保持Hy的分散并防止聚集和沉淀。Hy @ MCM‐41已成功应用于具有铱化合物[Ir（ppy）2bpy] Cl和三乙胺（TEA）分别作为光敏剂和牺牲电子供体，表现出良好的稳定性和催化活性。本研究提供了使用介孔分子筛在纯水中应用水不溶性催化剂的一般策略。
• Synthesis and characterization of novel 7-hydroxycoumarin derivatives
  作者：H. Mostafavi、R. Najjar、E. Maskani

  DOI：10.1007/s10600-013-0628-7

  日期：2013.7

  The synthesis of several coumarin Mannich bases is described. The reaction of natural 7-hydroxycoumarin with primary amines and two equivalents of formaldehyde in the presence of a base catalyst was studied. Several novel N-substituted angular 9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-ones were synthesized. Different aliphatic and aromatic amines have been used in the reaction, and the corresponding products were obtained with moderate to relatively good yields.

  描述了几种香豆素曼尼希碱的合成。研究了天然7-羟基香豆素与伯胺和两当量甲醛在碱催化剂存在下的反应。合成了几种新型N-取代角9,10-二氢-2H,8H-色并[8,7-e][1,3]恶嗪-2-酮。反应中使用了不同的脂肪族和芳香族胺，得到了相应的产物，收率中等至较好。
• Synthesis and Antimicrobial Activity of 3-Substituted 8-Propenylbenzo[e][1,3]oxazines
  作者：G. M. Mehdiyeva

  DOI：10.1134/s1070427222020070

  日期：2022.2

  spectroscopy. The antimicrobial activity of the compounds against Staphylococcus aureus (two strains), Escherichia coli, Candida albicans, Shigella flexneri, Salmonella enterica, and Aspergillus niger was evaluated in 5, 15, and 35 mg L–1 solutions. The benzoxazine containing the benzyl fragment shows the best antimicrobial properties. To confirm the antimicrobial activity of the compounds in lower concentrations

  摘要 通过 2-丙烯基苯酚、甲醛和伯胺（苯胺、丙胺、己胺和苄胺）的三元曼尼希缩合制备一系列 1,3-苯并恶嗪衍生物。产物结构通过元素分析和红外和核磁共振光谱证实。化合物对金黄色葡萄球菌（两种菌株）、大肠杆菌、白色念珠菌、福氏志贺氏菌、肠沙门氏菌和黑曲霉的抗菌活性在 5、15 和 35 mg L –1中进行了评估解决方案。含有苄基片段的苯并恶嗪显示出最好的抗菌性能。为了确认化合物在较低浓度下的抗菌活性，进行了连续稀释测试，并确定了最小抑制浓度 (0.035 mg L –1 )。通过电子显微镜检查在存在具有苄基取代基的化合物的情况下大肠杆菌细胞的超微结构。
• CONDITIONING AGENT AND A METHOD FOR MAKING HAIR HAVING A SHAPE MEMORY EFFECT
  申请人：Hu Jinlian

  公开号：US20090311210A1

  公开（公告）日：2009-12-17

  A method of imparting a shape memory effect to hair may include administrating an effective amount of a hair-conditioning agent to hair. The hair-conditioning agent may include a shape memory polymer selected from the group consisting of a polyurethane, an acrylic acid copolymer, a pyridine-based copolymer, and a pyrrolidone copolymer.
• PHOSPHORUS NITROGEN FLAME RETARDANT, METHOD THEREOF AND MATERIAL COMPRISING THE SAME
  申请人：ZHOU Chongfu

  公开号：US20220127533A1

  公开（公告）日：2022-04-28

  Provided are phosphorus nitrogen flame retardants represented by Formula III, a method of preparing the flame retardants without using any solvent, and various materials comprising the flame retardants. Rb and Rc are independently of each other selected from hydrogen, substituted or unsubstituted alkyl such as C1-C18 alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclic alkyl, substituted or unsubstituted heterocycles, substituted or unsubstituted aryl such as C6˜C18 aryl, substituted or unsubstituted heteroaryl such as C3˜C18 heteroaryl, and acyl radical. The invention exhibits numerous technical merits such as excellent flame retardant efficacy, good compatibility with polymers, lower migration to material surface, excellent hydrolysis resistance, low smoke and low toxicity during burning, simpler preparation process, fewer by-products, shorter reaction time, higher yield, and no environmental impact, among others.