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5-Hydroxy-1-[3-methoxy-4-(tetrahydro-pyran-2-yloxy)-phenyl]-dodecan-3-one | 336784-92-0

中文名称
——
中文别名
——
英文名称
5-Hydroxy-1-[3-methoxy-4-(tetrahydro-pyran-2-yloxy)-phenyl]-dodecan-3-one
英文别名
5-Hydroxy-1-[3-methoxy-4-(oxan-2-yloxy)phenyl]dodecan-3-one;5-hydroxy-1-[3-methoxy-4-(oxan-2-yloxy)phenyl]dodecan-3-one
5-Hydroxy-1-[3-methoxy-4-(tetrahydro-pyran-2-yloxy)-phenyl]-dodecan-3-one化学式
CAS
336784-92-0
化学式
C24H38O5
mdl
——
分子量
406.563
InChiKey
SZTYWQZRRIOQML-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    541.6±50.0 °C(Predicted)
  • 密度:
    1.059±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    5.4
  • 重原子数:
    29
  • 可旋转键数:
    14
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.71
  • 拓扑面积:
    65
  • 氢给体数:
    1
  • 氢受体数:
    5

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    5-Hydroxy-1-[3-methoxy-4-(tetrahydro-pyran-2-yloxy)-phenyl]-dodecan-3-one4-甲基苯磺酸吡啶 作用下, 以 乙醇 为溶剂, 以37%的产率得到[8]-shogaol
    参考文献:
    名称:
    Pharmaceutical compositions useful in prevention and treatment of beta-Amyloid protein-induced disease
    摘要:
    这项发明提供了用于治疗β-淀粉样蛋白诱导疾病的方法,以及用于相同目的的药物组合物和化合物,以及利用这些化合物制造治疗该疾病的药物的用途。更具体地说,该发明涉及利用从姜黄、银杏和姜中分离的天然产物化合物以及其合成化学类似物,用于治疗β-淀粉样蛋白诱导的疾病。
    公开号:
    US06887898B1
  • 作为产物:
    参考文献:
    名称:
    Side-chain length is important for shogaols in protecting neuronal cells from β-amyloid insult
    摘要:
    Ten shogaols were synthesized to evaluate the importance of the side-chain length in protecting cells from betaA(1-42) insult using PC12 rat pheochromocytoma and IMR-32 human neuroblastoma cells. The compounds cell protectivity against betaA insult was demonstrated using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) reduction assay. The efficacy of cell protection from betaA insult by these shogaols was shown to improve as the length of the side chain increase. (C) 2003 Elsevier Ltd. All rights reserved.
    DOI:
    10.1016/j.bmcl.2003.12.041
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文献信息

  • Synergistic pharmaceutical compositions useful in prevention and treatment of beta-amyloid protein-induced disease
    申请人:Kim S. H. L. Darrick
    公开号:US20070003641A1
    公开(公告)日:2007-01-04
    Disclosed are combinations of natural and synthetic turmeric, ginger, ginko biloba, sage, and rosemary compounds suitable for treatment of beta-amyloid-disease induced disease that have synergistic anti-βA peptide effects when members of the five groups of compounds are combined. Suitable members of the compounds include both natural compounds derived from extracts of each of Curcuma sp., Zingiber sp., Ginkgo biloba, Salvia sp., or Rosmarinus sp. as well as synthetic homologues and analogues of such natural compounds. Sage and rosemary derived compounds suitable alone for treatment of beta-amyloid induced disease is also described.
  • US7728043B2
    申请人:——
    公开号:US7728043B2
    公开(公告)日:2010-06-01
  • Side-chain length is important for shogaols in protecting neuronal cells from β-amyloid insult
    作者:Darrick S.H.L Kim、Jin Yung Kim
    DOI:10.1016/j.bmcl.2003.12.041
    日期:2004.3
    Ten shogaols were synthesized to evaluate the importance of the side-chain length in protecting cells from betaA(1-42) insult using PC12 rat pheochromocytoma and IMR-32 human neuroblastoma cells. The compounds cell protectivity against betaA insult was demonstrated using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) reduction assay. The efficacy of cell protection from betaA insult by these shogaols was shown to improve as the length of the side chain increase. (C) 2003 Elsevier Ltd. All rights reserved.
  • Pharmaceutical compositions useful in prevention and treatment of beta-Amyloid protein-induced disease
    申请人:Kim Darrick S. H. L.
    公开号:US06887898B1
    公开(公告)日:2005-05-03
    The invention provides methods for treating beta-Amyloid protein-induced disease, pharmaceutical compositions and compounds useful for the same, and the use of these compounds for the manufacture of a medicament for treating the same. More particularly, the invention relates to the use of natural product compounds isolated from turmeric, gingko biloba, and ginger, and synthetic chemical analogues thereof, for the treatment of a beta-Amyloid protein-induced disease.
    这项发明提供了用于治疗β-淀粉样蛋白诱导疾病的方法,以及用于相同目的的药物组合物和化合物,以及利用这些化合物制造治疗该疾病的药物的用途。更具体地说,该发明涉及利用从姜黄、银杏和姜中分离的天然产物化合物以及其合成化学类似物,用于治疗β-淀粉样蛋白诱导的疾病。
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