N-acetyl-DL-penicillamine N-hydroxysuccinimidate | 1227401-43-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-acetyl-DL-penicillamine N-hydroxysuccinimidate
• 英文别名: (2,5-Dioxopyrrolidin-1-yl) 2-acetamido-3-methyl-3-sulfanylbutanoate；(2,5-dioxopyrrolidin-1-yl) 2-acetamido-3-methyl-3-sulfanylbutanoate
• CAS: 1227401-43-5
• 化学式: C₁₁H₁₆N₂O₅S
• 分子量: 288.324
• InChiKey: OSNGIUSSMUNEQR-UHFFFAOYSA-N

物化性质

• 密度：
  1.33±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  93.8
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N-羟基丁二酰亚胺 、 N-乙酰基-D-青霉胺 在 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以100%的产率得到N-acetyl-DL-penicillamine N-hydroxysuccinimidate
  参考文献：
  名称：

  PS-SNAP, a practical polymer-supported nitrosation reagent in organic synthesis

  摘要：

  PS-SNAP was designed and evaluated as a practical nitrosating polymer-supported reagent for the nitrosation of sec-amines. Nitrosated dialkyl amines, alkyl anilines, and bis-anilines were obtained in good yields and high purities after shaking the corresponding amines in the presence of an excess of the newly described reagent followed by simple filtration and removal of solvents. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.02.135

文献信息

• PS-SNAP, a practical polymer-supported nitrosation reagent in organic synthesis
  作者：Didier Roche、Claude Lardy、Lucie Tournier、Marc Prunier、Eric Valeur

  DOI：10.1016/j.tetlet.2010.02.135

  日期：2010.4

  PS-SNAP was designed and evaluated as a practical nitrosating polymer-supported reagent for the nitrosation of sec-amines. Nitrosated dialkyl amines, alkyl anilines, and bis-anilines were obtained in good yields and high purities after shaking the corresponding amines in the presence of an excess of the newly described reagent followed by simple filtration and removal of solvents. (C) 2010 Elsevier Ltd. All rights reserved.