2-(4-Chlorophenoxy)butyric acid chloride | 56895-14-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(4-Chlorophenoxy)butyric acid chloride
• 英文别名: 2-(4-chlorophenoxy)butyryl chloride；2-(4-Chlorophenoxy)butanoyl chloride
• CAS: 56895-14-8
• 化学式: C₁₀H₁₀Cl₂O₂
• mdl: MFCD12197833
• 分子量: 233.094
• InChiKey: LGEVIMQAAQJLEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为反应物：
  描述：

  2-(4-Chlorophenoxy)butyric acid chloride 在 lithium hydroxide 、 正丁基锂 、 水 、 双氧水 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 1.25h， 生成 (R)-2-(4-chlorophenoxy)butanoic acid
  参考文献：
  名称：

  Direct resolution of α-monoalkyl-α-aryloxyacetic acids via ester or imide derivatives

  摘要：

  This paper describes a simple procedure for the resolution of racemic alpha-monoalkyl alpha-aryloxyacetic acids, using the chromatographic separation of their covalent derivatives. (R)-Ethyl mandelate, (R)-pantolactone and (S)-4-(1-methylethyl)-2-oxazolidinone are the resolving agents involved in the formation of equimolecular diastereomeric mixtures of esters or imides. Chromatograpkic resolutions were performed by means of gas chromatography (GC), thin-layer chromatography (TLC) and flash chromatography. Successive hydrolysis of separated diastereomers provided optically pure aryloxyacetic acids. (C) 1998 Elsevier Science S.A.

  DOI：

  10.1016/s0014-827x(97)00010-4
• 作为产物：
  描述：

  对氯苯酚 在 sodium hydroxide 、 氯化亚砜 作用下， 以 乙醇 为溶剂， 反应 26.0h， 生成 2-(4-Chlorophenoxy)butyric acid chloride
  参考文献：
  名称：

  突触前胆碱能调节剂可作为有效的认知增强剂和止痛药。2.2-苯氧基-，2-（苯硫基）-和2-（苯氨基）链烷酸酯。

  摘要：

  据报道，对铅的进一步修饰（（R）-（+）-水苏胺和（对-氯苯基）丙酸α-托帕尼酯），由于增加的中央突触前ACh释放而显示出止痛和促智活性。2-苯氧基-和2-（苯硫基）链烷酸酯显示了最佳结果。这些类别中的几个成员具有与吗啡相当的镇痛作用，同时能够逆转由二环胺引起的健忘症。证实作用机制是由于中央毒蕈碱突触中ACh释放的增加所致，控制ACh释放的自体和异体受体极有可能参与其中。根据（R）-（+）-硫辛胺获得的结果，镇痛活性与立体化学有关，因为R-（+）-对映异构体总是比相应的S-（-）-one更有效。根据其效力和急性毒性，选择化合物（+/-）-28（SM21）和（+/-）-42（SM32）进行进一步研究。

  DOI：

  10.1021/jm00037a023

文献信息

• Indane-1,3-dione derivatives
  申请人：Societe d'Etude et d'Eploitation de Marques Mar-Pha

  公开号：US03957879A1

  公开（公告）日：1976-05-18

  The invention provides compounds of formula: ##SPC1## Wherein each of the groups R.sub.1 and R.sub.2, which may be the same or different, is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms and R.sub.3 is a hydrogen or halogen atom, an alkyl group having 1 to 3 carbon atoms or a methoxy, trifluoromethyl or nitro group. The compounds are useful for inducing hypothrombinaemia.

  本发明提供了式子为：##SPC1## 的化合物，其中R.sub.1和R.sub.2两个基团可以相同也可以不同，分别为氢原子或者有1到3个碳原子的烷基基团，R.sub.3为氢原子、卤素原子、有1到3个碳原子的烷基基团、甲氧基、三氟甲基或者硝基。这些化合物可用于诱导低凝血素血症。
• 2-(4-R-Phenoxy/phenylthio)alkanoic esters of l-lupinine
  作者：Anna Sparatore、Fabio Sparatore

  DOI：10.1016/s0014-827x(01)01036-9

  日期：2001.4

  Considering the great pharmacological interest in phenoxy/phenylthioalkanoic esters of open-chain or cyclic aminoalcohols, a set of ten such esters of lupinine was prepared. Initially, their ability to displace [H-3]QNB from rat brain preparation was investigated. With the exception of two, all the prepared esters exhibited good affinity to muscarinic receptors (on a non-selective basis), with pK(i) in the range 6.67-7.68. (C) 2001 Elsevier Science S.A. All rights reserved.
• TAKEHMATSU, TEHTSUO;TAKEHUTI, YASUTOMO;TAKEHNAKA, MITSUAKI;TAKAMURA, SAJD+
  作者：TAKEHMATSU, TEHTSUO、TAKEHUTI, YASUTOMO、TAKEHNAKA, MITSUAKI、TAKAMURA, SAJD+

  DOI：——

  日期：——
• Direct resolution of α-monoalkyl-α-aryloxyacetic acids via ester or imide derivatives
  作者：Rosa Amoroso、Giancarlo Bettoni、Maria Luisa Tricca、Fulvio Loiodice、Savina Ferorelli

  DOI：10.1016/s0014-827x(97)00010-4

  日期：1998.1

  This paper describes a simple procedure for the resolution of racemic alpha-monoalkyl alpha-aryloxyacetic acids, using the chromatographic separation of their covalent derivatives. (R)-Ethyl mandelate, (R)-pantolactone and (S)-4-(1-methylethyl)-2-oxazolidinone are the resolving agents involved in the formation of equimolecular diastereomeric mixtures of esters or imides. Chromatograpkic resolutions were performed by means of gas chromatography (GC), thin-layer chromatography (TLC) and flash chromatography. Successive hydrolysis of separated diastereomers provided optically pure aryloxyacetic acids. (C) 1998 Elsevier Science S.A.
• Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 2. 2-Phenoxy-, 2-(Phenylthio)-, and 2-(Phenylamino)alkanoic Acid Esters
  作者：Fulvio Gualtieri、Claudia Bottalico、Anna Calandrella、Silvia Dei、Maria Paola Giovannoni、Stefania Mealli、Maria Novella Romanelli、Serena Scapecchi、Elisabetta Teodori

  DOI：10.1021/jm00037a023

  日期：1994.5

  leads ((R)-(+)-hyoscyamine and (p-chlorophenyl)propionic acid alpha-tropanyl ester), which show analgesic and nootropic activities as a consequence of increased central presynaptic ACh release, are reported. 2-Phenoxy- and 2-(phenylthio)alkanoic acid esters showed the best results. Several members of these classes possess analgesic properties which are comparable to that of morphine and at the same time

  据报道，对铅的进一步修饰（（R）-（+）-水苏胺和（对-氯苯基）丙酸α-托帕尼酯），由于增加的中央突触前ACh释放而显示出止痛和促智活性。2-苯氧基-和2-（苯硫基）链烷酸酯显示了最佳结果。这些类别中的几个成员具有与吗啡相当的镇痛作用，同时能够逆转由二环胺引起的健忘症。证实作用机制是由于中央毒蕈碱突触中ACh释放的增加所致，控制ACh释放的自体和异体受体极有可能参与其中。根据（R）-（+）-硫辛胺获得的结果，镇痛活性与立体化学有关，因为R-（+）-对映异构体总是比相应的S-（-）-one更有效。根据其效力和急性毒性，选择化合物（+/-）-28（SM21）和（+/-）-42（SM32）进行进一步研究。