(5-hydroxy-4-oxo-4H-pyran-2-yl)methyl propionate | 40838-39-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: (5-hydroxy-4-oxo-4H-pyran-2-yl)methyl propionate
• 英文别名: 5-hydroxy-4H-pyran-4-on-2-methyl propionate；(5-Hydroxy-4-oxopyran-2-yl)methyl propanoate
• CAS: 40838-39-9
• 化学式: C₉H₁₀O₅
• 分子量: 198.175
• InChiKey: BKPJZKMZFJHWQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  曲酸 在 吡啶 、 5%-palladium/activated carbon 、 氢气 、 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 26.0h， 生成 (5-hydroxy-4-oxo-4H-pyran-2-yl)methyl propionate
  参考文献：
  名称：

  A FACILE SYNTHESIS OF (5-HYDROXY-4-OXO-4H-PYRAN-2-YL)METHYL CARBOXYLATES AND THEIR ANTIVIRAL ACTIVITY AGAINST HEPATITIS C VIRUS

  摘要：

  5-Benzyloxy-2-hydroxymethyl-4H-pyran-4-one (2) was synthesized from kojic acid (1) and subsequently reacted with carboxylic anhydride (3a) and a series of carboxylic acid chlorides (3b-l) to give the corresponding (5-benzyloxy-4-oxo-4H-pyran-2-yl)methyl carboxylates (4a-l). These compounds were, then reductively debenzylated to afford the (5-hydroxy-4-oxo-4H-pyran-2-yl)methyl carboxylates (5a-l), which were tested for their inhibitory activities against the hepatitis C virus.

  DOI：

  10.3987/com-13-12726

文献信息

• Hydroxybenzyl or hydroxypyranonemethyl esters as tyrosinase inhibitors
  申请人：Clendennen Stephanie Kay

  公开号：US20080306144A1

  公开（公告）日：2008-12-11

  Method for the preparation of ester compounds for use as skin brightening agents and compositions for brightening skin containing the ester compounds.

  用作皮肤美白剂的酯化合物的制备方法和含有该酯化合物的美白皮肤组合物。
• A FACILE SYNTHESIS OF (5-HYDROXY-4-OXO-4H-PYRAN-2-YL)METHYL CARBOXYLATES AND THEIR ANTIVIRAL ACTIVITY AGAINST HEPATITIS C VIRUS
  作者：Tetsuro Shimo、Yuki Taketsugu、Takuya Goto、Masaaki Toyama、Kohji Yoshimura、Masanori Baba

  DOI：10.3987/com-13-12726

  日期：——

  5-Benzyloxy-2-hydroxymethyl-4H-pyran-4-one (2) was synthesized from kojic acid (1) and subsequently reacted with carboxylic anhydride (3a) and a series of carboxylic acid chlorides (3b-l) to give the corresponding (5-benzyloxy-4-oxo-4H-pyran-2-yl)methyl carboxylates (4a-l). These compounds were, then reductively debenzylated to afford the (5-hydroxy-4-oxo-4H-pyran-2-yl)methyl carboxylates (5a-l), which were tested for their inhibitory activities against the hepatitis C virus.