2-(2-bromoethoxy)tetrahydro-2H-pyran | 57626-16-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 2-(2-bromoethoxy)tetrahydro-2H-pyran
• 英文别名: 2-(2-Bromoethoxy)-2H-pyran
• CAS: 57626-16-1
• 化学式: C₇H₉BrO₂
• 分子量: 205.051
• InChiKey: ADGUPKFOOCCMII-UHFFFAOYSA-N

物化性质

• 沸点：
  285.4±40.0 °C(Predicted)
• 密度：
  1.47±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(2-bromoethoxy)tetrahydro-2H-pyran 、 乙酰苯 在 potassium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 生成
  参考文献：
  名称：

  Olefins Turned Alkylating Agents:  Diastereoselective Intramolecular Zr-Catalyzed Olefin Alkylations

  摘要：

  The first examples of intramolecular Zr-catalyzed electrophilic alkylation of aryl olefins are disclosed. Substituted carbo- and heterocycles are prepared efficiently and diastereoselectively.

  DOI：

  10.1021/ol017090c

文献信息

• Substituted piperazines and diazepanes
  申请人：——

  公开号：US20040019039A1

  公开（公告）日：2004-01-29

  A novel class of substituted piperazines and diazepanes, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.

  一种新型的取代哌嗪和二氮杂环庚烷类化合物，包括它们的药物组合物以及在治疗与组胺H3受体相关的疾病和紊乱中的应用。更具体地说，这些化合物对于治疗需要与组胺H3受体相互作用有益的疾病和紊乱是有用的。
• Cyclopropyl derivative lipoxygenase inhibitors
  申请人：Abbott Laboratories

  公开号：US05120752A1

  公开（公告）日：1992-06-09

  Certain carbocyclic aryl- and heterocyclic aryl- substituted cyclopropyl N-hydroxyureas, N-hydroxy-carboxamides, and N-acyl-N-hydroxyamines inhibit 5- and/or 12-lipoxygenase and are useful in the treatment of inflammatory disease states.

  某些含有碳环芳基和杂环芳基的环丙基N-羟基脲、N-羟基羧酰胺和N-酰基-N-羟基胺抑制5-和/或12-脂氧合酶，并且在治疗炎症性疾病状态方面有用。
• Lipid derivatives their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0157609A2

  公开（公告）日：1985-10-09

  Novel lipid derivatives of the formula [wherein R1 is alkyl or alkylcarbamoyl; R2 is hydrogen, hydroxy which may be substituted, amino which may be substituted or cyclic amino; R3 is chemical binding or alkylene which may be substituted; R4 is hydrogen, alkyl or aralkyl; X and Y are independently 0, S or an imino group which may be substituted, and when Y is an imino group, Y, together with the imino group represented by X or R4, may form a ring; and Z is imino or a nitrogen-containing heterocyclic ring which may be substituted] and salts thereof have inhibiting activity on platelet activating factor and are useful as a preventive or therapeutic agent for a variety of circulatory diseases and allergic disorders and also as an antineoplastic agent.

  式[其中 R1 是烷基或烷基氨基甲酰基；R2 是氢、可被取代的羟基、可被取代的氨基或环状氨基；R3 是化合价或可被取代的亚烷基；R4 是氢、烷基或芳烷基；X 和 Y 独立地是 0、S 或可被取代的亚氨基，当 Y 是亚氨基时，Y 与 X 或 R4 所代表的亚氨基可形成一个环；Z 是亚氨基或可被取代的含氮杂环]的新型脂质衍生物及其盐类对血小板活化因子具有抑制活性，可用作各种循环系统疾病和过敏性疾病的预防或治疗剂，也可用作抗肿瘤剂。
• SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS
  申请人：High Point Pharmaceuticals, LLC

  公开号：EP1421071B1

  公开（公告）日：2009-11-18
• JPH0418078A
  申请人：——

  公开号：JPH0418078A

  公开（公告）日：1992-01-22