1-(furan-2-ylmethyl)-pyrrolidine-2,5-dione | 343791-91-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-(furan-2-ylmethyl)-pyrrolidine-2,5-dione
• 英文别名: 1-(Furan-2-ylmethyl)pyrrolidine-2,5-dione
• CAS: 343791-91-3
• 化学式: C₉H₉NO₃
• 分子量: 179.175
• InChiKey: MRNLKAQIZDOWMU-UHFFFAOYSA-N

物化性质

• 熔点：
  110 °C(Solvent: Methanol)
• 沸点：
  379.3±25.0 °C(Predicted)
• 密度：
  1.338±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  50.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(furan-2-ylmethyl)-pyrrolidine-2,5-dione 、 硝酸 以56%的产率得到
  参考文献：
  名称：

  BARTROLI RIVAS R.; DIAZ LUZBET M.; COSTA BRAVO M.; LAMI IZQUIERDO L.; OLA+, ICIDCA , 1978, 12, NO 1, 46-55

  摘要：

  DOI：
• 作为产物：
  描述：

  2-呋喃甲胺 、 丁二酸 以 水 为溶剂， 反应 2.5h， 以36%的产率得到1-(furan-2-ylmethyl)-pyrrolidine-2,5-dione
  参考文献：
  名称：

  N-烷基和N-芳基琥珀酰亚胺在热水中的简单高效合成

  摘要：

  摘要描述了一种新的、简单的琥珀酰亚胺合成方法。反应在最终绿色条件下进行，不包括催化剂和有机溶剂，在 100 °C 下进行简单搅拌。已经通过在热水中使用琥珀酸和伯胺以高产率制备了多种 N-取代的琥珀酰亚胺。发现N-烷基取代的琥珀酰亚胺的产率高于N-芳基取代的琥珀酰亚胺的产率。图形概要

  DOI：

  10.1080/00397911.2016.1258479

文献信息

• Direct Synthesis of Cyclic Imides from Carboxylic Anhydrides and Amines by Nb₂ O₅ as a Water-Tolerant Lewis Acid Catalyst
  作者：Md. A. Ali、Sondomoyee K. Moromi、Abeda S. Touchy、Ken-ichi Shimizu

  DOI：10.1002/cctc.201501172

  日期：2016.3.7

  highest activity for the synthesis of N‐phenylsuccinimide by dehydrative condensation of succinic anhydride and aniline. Nb2O5 was used in the direct imidation of a wide range of carboxylic anhydrides with NH3 or amines with various functional groups and could be reused. Kinetic studies showed that the Lewis acid Nb2O5 catalyst was more water tolerant than both the Lewis acidic oxide TiO2 and the homogeneous

  在筛选的20种非均相和均相催化剂中，Nb 2 O 5通过琥珀酸酐和苯胺的脱水缩合合成N-苯基琥珀酰亚胺的活性最高。Nb 2 O 5用于直接将各种羧酸酐与NH 3或具有各种官能团的胺直接酰亚胺化，可以重复使用。动力学研究表明，路易斯酸Nb 2 O 5催化剂比路易斯酸性氧化物TiO 2和均相路易斯酸ZrCl 4具有更高的耐水性，这通过使用Nb可以提高酰亚胺的收率。2 O 5。
• Versatile and Sustainable Synthesis of Cyclic Imides from Dicarboxylic Acids and Amines by Nb₂O₅as a Base-Tolerant Heterogeneous Lewis Acid Catalyst
  作者：Md. Ayub Ali、S. M. A. Hakim Siddiki、Kenichi Kon、Junya Hasegawa、Ken-ichi Shimizu

  DOI：10.1002/chem.201404538

  日期：2014.10.27

  Catalytic condensation of dicarboxylics acid and amines without excess amount of activating reagents is the most atom‐efficient but unprecedented synthetic method of cyclic imides. Here we present the first general catalytic method, proceeding selectively and efficiently in the presence of a commercial Nb2O5 as a reusable and base‐tolerant heterogeneous Lewis acid catalyst. The method is effective for

  二羧酸和胺的催化缩合反应没有过量的活化剂是最高效，最空前的环状酰亚胺合成方法。在这里，我们介绍了第一种通用催化方法，该方法在作为可重用和耐碱多相路易斯酸催化剂的商业Nb 2 O 5的存在下选择性而有效地进行。该方法可有效地从二羧酸或酸酐与胺，羟胺或氨直接合成药学上或工业上重要的环状酰亚胺，例如苯甲酰亚胺，N-羟基邻苯二甲酰亚胺（NHPI）和未取代的环状酰亚胺。
• Sondhi, Sham M.; Jain, Shubhi; Rani, Reshma, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2007, vol. 46, # 11, p. 1848 - 1854
  作者：Sondhi, Sham M.、Jain, Shubhi、Rani, Reshma、Kumar, Ashok

  DOI：——

  日期：——
• REVERSIBLE CROSSLINKING REACTANT COMPOSITION
  申请人：INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

  公开号：US20210047282A1

  公开（公告）日：2021-02-18

  A reversible crosslinking reactant composition is provided. The composition includes at least one furan-group-containing oligomer and a bismaleimide compound having a structure represented by Formula (II), wherein the furan-group-containing oligomer is an oligomer having a structure represented by Formula (IV), an oligomer having a structure represented by Formula (V), or an oligomer having a first repeating unit and a second repeating unit, wherein the first repeating unit has a structure represented by Formula (VI), the second repeating unit has a structure represented by Formula (VII), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 19 , R 20 , R 21 , R 22 , R 23 , R 24 , R 25 , q, z and E are as defined in specification.
• Simple and efficient synthesis of N-alkyl and N-aryl succinimides in hot water
  作者：Burcu Bozdoğan、Mehmet Erşatır、Onur Demirkol、Dilek Akbaşlar、E. Sultan Giray

  DOI：10.1080/00397911.2016.1258479

  日期：2017.2.1

  ABSTRACT A new, simple synthesis of succinimides is described. The reactions were carried out under the ultimate green conditions excluding both catalyst and organic solvent by applying simple stirring at 100 °C. A wide variety of N-susbstituted succinimides have been prepared in high yields by using succinic acid and primary amines in hot water. Yield of N-alkyl substituted succinimides were found

  摘要描述了一种新的、简单的琥珀酰亚胺合成方法。反应在最终绿色条件下进行，不包括催化剂和有机溶剂，在 100 °C 下进行简单搅拌。已经通过在热水中使用琥珀酸和伯胺以高产率制备了多种 N-取代的琥珀酰亚胺。发现N-烷基取代的琥珀酰亚胺的产率高于N-芳基取代的琥珀酰亚胺的产率。图形概要