trans-humulinic acid | 24184-13-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 乙烯基酸
• 英文名称: trans-humulinic acid
• 英文别名: trans-humulinsaeure；Humilinic acid A；Humulinsaeure A
• CAS: 24184-13-2
• 化学式: C₁₅H₂₂O₄
• 分子量: 266.337
• InChiKey: PPIJHFDNRWNWJU-YGRLFVJLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.33
• 重原子数：
  19.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  74.6
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  律草酮 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 2.0h， 以78%的产率得到
  参考文献：
  名称：

  Oxidation of Isohumulones Induces the Formation of Carboxylic Acids by Hydrolytic Cleavage

  摘要：

  The degradation of isohumulones in mechanistic experiments was investigated. Incubation of trans-isohumulone in the presence of L-proline led to the formation of carboxylic acids and their corresponding proline amides. In the context of isohumulones unknown amides were verified first in model incubations and then in beer for the first time by comparison with authentic reference standards via LC-MS analyses. Carboxylic acids and amides were formed preferably under oxidative conditions and increasing pH. Stable isotope experiments excluded the incorporation of molecular oxygen into carboxylic acids, strongly indicating a hydrolytic mechanism via beta-dicarbonyl cleavage. The proposed mechanism includes oxidation and thereby incorporation of molecular oxygen to the isohumulone ring structure followed by hydrolytic cleavage leading to acids and amides.

  DOI：

  10.1021/jf501826h

文献信息

• ALKALINE DECOMPOSITION PRODUCT OF HOP EXTRACT AND USE THEREOF
  申请人：Kirin Holdings Kabushiki Kaisha

  公开号：EP2441463A1

  公开（公告）日：2012-04-18

  According to the present invention, there are provided a food and a food additive obtained using an alkaline decomposition product of a hop extract, and an agent for suppressing fat accumulation or for suppressing weight gain comprising the same as an active ingredient.

  根据本发明，提供了一种利用酒花提取物的碱性分解产物获得的食品和食品添加剂，以及一种抑制脂肪堆积或抑制体重增加的制剂，其有效成分包括酒花提取物。
• Treating or preventing illness growth of clostridium difficile
  申请人：——

  公开号：US20010014365A1

  公开（公告）日：2001-08-16

  The present invention relates to the discovery that hop extract is useful as an antibacterial agent against the dangerous pathogens Clostridium botulinum, Clostridium difficile , and Helicobacter pylori at levels below that at which a flavor from the acids contained therein is objectionable. More specifically, a process and associated product is described herein, comprising applying a solution of hop extract to a food, beverage or other medium so that the final concentration of hop ingredients is about 1 ppm or higher in order to inhibit the growth of Clostridium botulinum, Clostridium difficile , and/or Helicobacter pylori.

  本发明涉及发现啤酒花提取物可作为抗菌剂用于抵抗以下危险病原体 肉毒梭状芽孢杆菌、艰难梭状芽孢杆菌 和 幽门螺旋杆菌 啤酒花萃取物的抗菌能力低于其中所含酸的味道会引起反感的水平。更具体地说，本文描述了一种工艺和相关产品，包括将酒花提取物溶液施加到食品、饮料或其他介质中，使酒花成分的最终浓度约为 1 ppm 或更高，以抑制以下细菌的生长：肉毒梭菌、艰难梭菌和幽门螺旋杆菌。 肉毒梭状芽孢杆菌、艰难梭状芽孢杆菌 和/或 幽门螺旋杆菌。
• COMPOSITIONS AND FOODS FOR IMPROVING LIPID METABOLISM
  申请人：KIRIN BEER KABUSHIKI KAISHA

  公开号：EP1481671B1

  公开（公告）日：2011-08-31
• Compositions and foods for improving lipid metabolism
  申请人：Yajima Hiroaki

  公开号：US20060233902A1

  公开（公告）日：2006-10-19

  It is intended to provide compositions and foods for use in the treatment, prophylaxis, or amelioration of diseases or symptoms which can be treated, prevented or ameliorated by activating PPAR, in particular, insulin resistant diabetes and hyperlipidemia. Namely, medicinal compositions usable in treating, preventing or improving diseases or symptoms which can be treated, prevented or ameliorated by activation PPAR which contain humulones, isohumulones or lupulones or pharmaceutically acceptable salts or solvates thereof.
• TASTE-MASKED DOSAGE FORMS
  申请人：MSB Holdings, Inc

  公开号：US20210346385A1

  公开（公告）日：2021-11-11

  Sublingual dosage forms comprising a bitter active ingredient (including sildenafil, tadalafil, tetrahydrocannabinol, and cannabidiol) and a bitterness reducing agent are described. Methods of treating sexual dysfunction by administering the sublingual dosage form to an individual in need thereof are also described.