4-amino-3-methyl-1H-pyrazolo[3,4-c]pyridazin-5-ylamine | 1216885-08-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 4-amino-3-methyl-1H-pyrazolo[3,4-c]pyridazin-5-ylamine
• 英文别名: 4-Amino-3-methyl-1h-pyrazolo[3,4-c]pyridazin-5-yl amine；3-methyl-2H-pyrazolo[3,4-c]pyridazine-4,5-diamine
• CAS: 1216885-08-3
• 化学式: C₆H₈N₆
• 分子量: 164.17
• InChiKey: PHKNLYVWXMWLGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  丁二酸 、 4-amino-3-methyl-1H-pyrazolo[3,4-c]pyridazin-5-ylamine 在 盐酸 作用下， 以 水 为溶剂， 反应 4.0h， 以86%的产率得到3-(8-methyl-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazin-2-yl)propionic acid
  参考文献：
  名称：

  2-Substituted-8-methyl-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazine as an anti-inflammatory agent

  摘要：

  A series of 8-methyl-2-substituted-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazine compounds have been synthesized in the present investigation utilizing Philips condensation (Philips, J Chem Soc 2393-2399, 1928). The anti-inflammatory activity of the synthesized compounds was evaluated using a carrageenin rat model.

  DOI：

  10.1007/s00044-009-9290-9
• 作为产物：
  描述：

  4,5-Dichloro-3-methyl-1H-pyrazolo[3,4-c]pyridazine 在 氨 作用下， 反应 6.0h， 以90%的产率得到4-amino-3-methyl-1H-pyrazolo[3,4-c]pyridazin-5-ylamine
  参考文献：
  名称：

  2-Substituted-8-methyl-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazine as an anti-inflammatory agent

  摘要：

  A series of 8-methyl-2-substituted-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazine compounds have been synthesized in the present investigation utilizing Philips condensation (Philips, J Chem Soc 2393-2399, 1928). The anti-inflammatory activity of the synthesized compounds was evaluated using a carrageenin rat model.

  DOI：

  10.1007/s00044-009-9290-9

文献信息

• 2-Substituted-8-methyl-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazine as an anti-inflammatory agent
  作者：Ashish Kumar Tewari、Rashmi Dubey、Anil Mishra

  DOI：10.1007/s00044-009-9290-9

  日期：2011.1

  A series of 8-methyl-2-substituted-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazine compounds have been synthesized in the present investigation utilizing Philips condensation (Philips, J Chem Soc 2393-2399, 1928). The anti-inflammatory activity of the synthesized compounds was evaluated using a carrageenin rat model.