acrylic acid succinimidyl ester | 1026370-24-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: acrylic acid succinimidyl ester
• 英文别名: acryloxysuccinimide；n-acryloxysuccinimide；N-acryloyloxy succinimide；(2,5-dioxopyrrolidin-3-yl) prop-2-enoate
• CAS: 1026370-24-0
• 化学式: C₇H₇NO₄
• 分子量: 169.137
• InChiKey: UFHSKEHEWFGEFH-UHFFFAOYSA-N

物化性质

• 沸点：
  345.2±35.0 °C(Predicted)
• 密度：
  1.32±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  72.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-羟基丁二酰亚胺 、 丙烯酰氯 以 (2S)-N-methyl-1-phenylpropan-2-amine hydrate 、 正己烷 、 氯仿 、 乙酸乙酯 、 三乙胺 为溶剂， 生成 acrylic acid succinimidyl ester
  参考文献：
  名称：

  Polymeric delivery agents and delivery agents compounds

  摘要：

  提供了用于传递活性物质的聚合传递剂、传递剂化合物和包含它们的组合物。同时还提供了给药和制备方法。

  公开号：

  US06627228B1

文献信息

• [EN] FORCE-RESPONSIVE POLYMERSOMES AND NANOREACTORS; PROCESSES UTILIZING THE SAME<br/>[FR] POLYMERSOMES ET NANORÉACTEURS SENSIBLES À LA FORCE; PROCÉDÉS LES UTILISANT
  申请人：ADOLPHE MERKLE INSTITUTE UNIV OF FRIBOURG

  公开号：WO2019034597A1

  公开（公告）日：2019-02-21

  The mechanically induced melting properties of DNA were employed to achieve force labile membranes is described. Nucleobase pairs were used as mechanophores. Adenine and thymine functionalized complementary amphiphilic block copolymers were self-assembled into polymersomes. The nucleobases formed hydrogen bonds which were disrupted upon force stimulation. The exposure of the disconnected nucleobases to the hydrophobic matrix of the membranes lead to a change of permeability which permitted the exchange of water-soluble molecules throughout the polymer matrix. Moreover, the encapsulation of horseradish peroxidase enabled the reaction of luminol with hydrogen peroxide to yield a luminescence producing species similar to the marine bioluminescence. Moreover, the same nano-reactors were employed to catalyze the formation of a polyacrylamide gel when force was applied. Insights into the change of permeability of supramolecular networks upon force are provided. These systems are useful for drug delivery, as nanoreactors and for the selective release of curing agents for 3D printing, or fragrances.

  DNA的机械诱导熔化特性被用来实现易受力破裂的膜。核碱基对被用作机械感受器。腺嘌呤和胸腺嘧啶功能化的互补两性分块共聚物自组装成聚合体囊。核碱基形成氢键，在受力刺激下被破坏。断开的核碱基暴露在膜的疏水基质中，导致渗透性的改变，从而允许水溶性分子在聚合物基质中交换。此外，封装辣根过氧化物酶使得辣根酰胺与过氧化氢反应产生类似海洋生物发光的发光物种。此外，当施加力时，相同的纳米反应器被用来催化聚丙烯酰胺凝胶的形成。提供了关于受力下超分子网络渗透性变化的见解。这些系统可用于药物传递、纳米反应器以及用于3D打印的固化剂或香料的选择性释放。
• Innervated artificial tissues and uses thereof
  申请人：Griffith May

  公开号：US20060034807A1

  公开（公告）日：2006-02-16

  A three dimensional, innervated artificial tissue comprising a bio-synthetic matrix is provided. The artificial tissue supports cell growth, including surface coverage and three-dimensional cell in-growth, as well as nerve in-growth. Methods of preparing the innervated artificial tissue and methods of innervating artificial tissues or tissue substitutes are also provided. The artificial tissue is useful for in vitro testing of various pharmaceutical, cosmetic and household products.

  提供了一种包括生物合成基质的三维神经化人工组织。这种人工组织支持细胞生长，包括表面覆盖和三维细胞生长，以及神经生长。还提供了制备这种神经化人工组织的方法，以及神经化人工组织或组织替代品的方法。这种人工组织对于体外测试各种药物、化妆品和家用产品非常有用。
• THERMORESPONSIVE, BIODEGRADABLE, ELASTOMERIC MATERIAL
  申请人：Guan Jianjun

  公开号：US20080096975A1

  公开（公告）日：2008-04-24

  Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers and degradation products thereof are non-toxic and typically have an LCST between room temperature and 37° C. so that they are liquid at room temperature and gelled at 37° C. which facilitates their use in humans, for example for wound treatment and as a cellular growth matrix or niche. The copolymer comprises numerous ester linkages in its backbone so that the copolymers are erodeable in situ. Degradation products of the polymer are soluble and non-toxic. The copolymer is amine-reactive so that it can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymer.

  提供了一种新型的生物相容性共聚物和包含该共聚物的组合物。该共聚物及其降解产物无毒，并通常具有在室温和37℃之间的LCST，因此它们在室温下是液态，在37℃时是凝胶状的，有助于它们在人体内的应用，例如用于创伤治疗以及作为细胞生长基质或环境。该共聚物的骨架中包含众多的酯键，因此它们可以在原位被侵蚀。聚合物的降解产物可溶性且无毒。该共聚物具有胺反应性，因此可以与蛋白质（如胶原蛋白）结合。包含该共聚物的组合物中可以加入活性成分，如药物。
• Magnetic fine particles and process for producing the same
  申请人：——

  公开号：US20030175826A1

  公开（公告）日：2003-09-18

  The present invention relates to magnetic fine particles having immobilized thereto a polymer having an upper critical solution temperature, and a process for producing the same, a method of separating or concentrating a microorganism, a method of purifying, detecting, or concentrating a nucleic acid, a separating agent, a method of separating a biological substance, and a method of converting a substance.

  本发明涉及具有固定在其上具有上临界溶液温度的聚合物的磁性细粒子，以及其制备方法，一种分离或浓缩微生物的方法，一种纯化、检测或浓缩核酸的方法，一种分离剂，一种分离生物物质的方法和一种转化物质的方法。
• Magnetic fine particles having lower critical solution temperature
  申请人：Furukawa Hirotaka

  公开号：US20050158782A1

  公开（公告）日：2005-07-21

  The present invention relates to magnetic fine particles having a lower critical solution temperature to which at least one substance selected from biotin and avidin is immobilized, and a method of converting a substance, a method of separating or concentrating a microorganism, a method of modifying a denatured protein, a method of detecting a nucleic acid, a separating agent, and a method of separating a biological substance using the same.

  本发明涉及具有较低临界溶液温度的磁性细粒子，其上固定了生物素和亲和素中至少一种物质，以及一种将物质转化的方法、一种微生物的分离或浓缩方法、一种变性蛋白质的修饰方法、一种检测核酸的方法、一种分离剂和使用它们分离生物物质的方法。