(-)-S-malathion | 145307-17-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (-)-S-malathion
• 英文别名: malathion；S_c-malathion；(S)-Malathion；diethyl (2S)-2-dimethoxyphosphinothioylsulfanylbutanedioate
• CAS: 145307-17-1
• 化学式: C₁₀H₁₉O₆PS₂
• 分子量: 330.363
• InChiKey: JXSJBGJIGXNWCI-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  128
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (-)-S-malathion 在 单过氧邻苯二甲酸 、 magnesium salt 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以53%的产率得到(S)-malaoxon
  参考文献：
  名称：

  Stereoselective and chemoselective oxidation of phosphorothionates using MMPP

  摘要：

  MMPP (monoperoxyphthalic acid, magnesium salt) converts phosphorothionates to the corresponding oxons in good yield with excellent chemoselectivity and stereoselectivity.

  DOI：

  10.1016/s0040-4039(00)60006-0
• 作为产物：
  描述：

  D-(+)-苹果酸二乙酯 在 lutidine 作用下， 生成 (-)-S-malathion
  参考文献：
  名称：

  Synthesis of chiral malathion and isomalathion

  摘要：

  The first synthesis of the chiral isomers of isomalathion and malathion are reported herein.

  DOI：

  10.1016/s0040-4039(00)91635-6

文献信息

• Furfural derivatives as a vehicle
  申请人：RHODIA OPERATIONS

  公开号：US20160000066A1

  公开（公告）日：2016-01-07

  The present invention concerns the use of a furfural derivative of formula (I) in which R represents (i) a —CH═CR′ 1 —COR 1 group, a group a group a group or a —CHO and R′ represents a hydrogen atom or a (C 1 -C 4 )alkyl group, as a chemical vehicle, as a solvent, co-solvent, coalescing agent, crystallization inhibitor, plasticising agent, degreasing agent, etchant, cleaning agent or agent for increasing biological activity, and more particularly as a solvent. It also concerns phytosanitary formulations or resin-solubilising formulations comprising at least one such furfural derivative of formula (I).

  本发明涉及将式(I)中R代表(i) -CH═CR′1-COR1基团，一个基团，一个基团，或-CHO，R′代表氢原子或(C1-C4)烷基基团的糠醛衍生物用作化学载体、溶剂、共溶剂、凝聚剂、结晶抑制剂、增塑剂、脱脂剂、蚀刻剂、清洁剂或增加生物活性的剂，更特别地作为溶剂。还涉及包含至少一种上述式(I)的糠醛衍生物的植物保健配方或树脂溶解配方。
• Enantiomeric separation of malathion and malaoxon and the chiral residue analysis in food and environmental matrix
  作者：Yifan Hua、Qian Zhou、Peng Wang、Zhiqiang Zhou、Donghui Liu

  DOI：10.1002/chir.23229

  日期：2020.8

  used chiral phosphorus insecticide, which has a more toxic chiral metabolite malaoxon. In this work, the enantiomers of malathion and malaoxon were separated by high‐performance liquid chromatography‐mass/mass (HPLC‐MS/MS) with chiral columns using acetonitrile/water or methanol/water as mobile phase, and the chromatographic conditions were optimized. Based on the chiral separation, the chiral residue

  马拉硫磷是一种广泛使用的手性磷杀虫剂，它具有更强的手性代谢产物马拉oxon。在这项工作中，使用乙腈/水或甲醇/水作为流动相的高效液相色谱-质量/质量（HPLC-MS / MS）手性色谱柱分离了马拉硫磷和马拉松的对映体，并优化了色谱条件。基于手性分离，建立了土壤，水果和蔬菜中对映体的手性残留分析方法。在CHIRALPAK IC手性色谱柱上可以更好地分离两对对映异构体，并以乙腈/水（40/60，v / v）作为流动相，以0.5 mL / min的流速实现马拉硫磷和丙二酮对映体的基线同时分离。通过旋光检测器测得的马拉硫磷和马拉松的洗脱顺序为-/ +。通过线性，回收率，精密度，检测限（LOD）和定量限（LOQ）验证了土壤，水果和蔬菜中的手性残留物分析。马拉硫磷对映体的LOD和LOQ为1μg/ kg，3-5μg/ kg，0.08μg/ kg和0.20–0.25μg/ kg。在0.02-12 mg /
• The separation of several organophosphate pesticides on immobilized polysaccharide chiral stationary phases
  作者：William L. Champion、William L. Watts、Weston J. Umstead

  DOI：10.1002/chir.23473

  日期：2022.8

  enantiomers of widely used pesticides. Of particular note are organophosphorus-based pesticides like fenamiphos and profenofos, as examples. This work explores the enantioselective high-performance liquid chromatography (HPLC) separations of seven such organophosphorus pesticides (OP's) on the library of immobilized polysaccharide-based chiral stationary phases (CSPs) with normal phase hexane/alcohol mixtures

  虽然最初不是重点或优先事项，但近几十年来，重点放在了广泛使用的农药的单个对映异构体的活性上。特别值得注意的是基于有机磷的杀虫剂，例如杀灭磷和丙溴磷。这项工作探索了七种此类有机磷农药 (OP) 在正相己烷/酒精混合物的固定化多糖基手性固定相 (CSP) 库上的对映选择性高效液相色谱 (HPLC) 分离。使用简单因子设计进一步探索流动相强度和温度对几种分离的影响。比较了几种温度和流动相组合的第一个洗脱对映异构体的等效保留峰形、选择性和分离度。类似地，在峰形、第一个洗脱对映异构体的保留和分离度方面比较了几种温度和流动相组合的等效选择性。本研究的结果提供了工作中包含的几种新的手性分离，这些手性分离包含在以前没有记录的工作中，包括最近商业化的三个阶段的分离，Chiralpak IH、IJ 和 IK。此外，获得了充分的理解，能够预测分辨率、分析时间、峰锐度（从而提高检测限 [LOD]/定量限 [LOQ
• Microcapsules and microencapsulation process
  申请人：STAUFFER CHEMICAL COMPANY

  公开号：EP0158449A1

  公开（公告）日：1985-10-16

  Novel microcapsules are disclosed in which a liquid material which is substantially insoluble in water is enclosed within a solid permeable shell of etherified urea-formaldehyde polymer, prepared by a process which comprises: (a) providing an organic solution comprising said material and a urea-formaldehyde prepolymer in which from about 50% to about 98% of the methylol groups of said prepolymer have been etherified with a C4-C10 alcohol; (b) creating an emulsion of said organic solution in an aqueous solution comprising water and a surface-active agent, wherein said emulsion comprises discrete droplets of said organic solution dispersed in said aqueous solution; (c) causing in situ self-condensation of said urea-formaldehyde prepolymers by adding to said emulsion an acidifying agent and maintaining said emulsion at a pH of between about 0 and about 4 for a sufficient period of time to allow substantial completion of in situ condensation of said resin prepolymers to convert the liquid droplets of said organic solution to capsules consisting of solid permeable polymer shells enclosing said liquid material; and (d) heating said emulsion to a temperature between about 20°C and about 100°C to cause curing of said in situ formed polymers.

  本发明公开了一种新型微胶囊，在这种微胶囊中，基本上不溶于水的液态材料被包裹在由醚化脲醛聚合物构成的固体可渗透外壳中，其制备过程包括(a) 提供一种有机溶液，该有机溶液包括所述材料和脲醛预聚物，其中所述预聚物约 50% 至约 98% 的甲醇基团已被 C4-C10 醇醚化；(b) 在由水和表面活性剂组成的水溶液中形成所述有机溶液的乳液，其中所述乳液包括分散在所述水溶液中的所述有机溶液的离散液滴；(c) 通过向所述乳液中添加酸化剂，并将所述乳液的 pH 值保持在约 0 至约 4 之间足够长的时间，使所述树脂预聚物的原位缩合基本完成，从而将所述有机溶液的液滴转化为由固态可渗透聚合物外壳组成的胶囊，将所述液态材料包裹起来，从而使所述脲醛预聚物原位自缩合；以及 (d) 将所述乳液加热至约 20°C 至约 100°C 之间的温度，使所述原位形成的聚合物固化。
• Stabilized agrochemical compositions
  申请人：NIHON BAYER AGROCHEM K.K.

  公开号：EP0431362A1

  公开（公告）日：1991-06-12

  Compositions which contain, as the active ingredients, a combination of a heterocyclic compound of the general formula (I) and an organophosphous compound, in addition to an amorphous silica additive selected from the class consisting of: (a) an amorphous silica obtained by a process, wherein an amorphous silica hydrate, which has been produced by a wet synthetic method, is either silylated or heated to effect an etherification so as to decrease the surface silanol radicals of the amorphous silica hydrate, and (b) an anhydrous, amorphous silica obtained by a dry synthetic method, or a silylated derivative thereof, and optionally one or more compounds having a polyethyleneglycol or polypropyleneglycol chain or an ethyleneglycolpropyleneglycol copolymeric chain, or a mixture of these compounds which results in a stabilization of the active ingredients without any adverse influences on the physical properties of the ingredients.

  含有通式(I)杂环化合物和有机膦化合物的组合物作为活性成分，此外还含有一种无定形二氧化硅添加剂，该添加剂从以下类别中选出： (a) 通过以下工艺获得的无定形二氧化硅：将用湿合成方法制得的无定形二氧化硅水合物进行硅烷化或加热以实现醚化，从而减少无定形二氧化硅水合物的表面硅烷醇基，以及 (b) 用干法合成法得到的无水无定形二氧化硅或其硅烷化衍生物、 以及一种或多种具有聚乙二醇或聚丙二醇链或乙二醇-丙二醇共聚物链的化合物，或这 些化合物的混合物，它们能稳定活性成分，而不会对成分的物理性质产生任何不利影响。