lidocainium hydrocarbonate | 856323-35-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: lidocainium hydrocarbonate
• 英文别名: Lidocaine bicarbonate；carbonic acid;2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
• CAS: 856323-35-8
• 化学式: CH₂O₃*C₁₄H₂₂N₂O
• 分子量: 296.367
• InChiKey: QOKQKHSBEYXQLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.81
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  89.9
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  二氧化碳 、 盐酸利多卡因 在 碳酸氢钠 作用下， 以 水 为溶剂， -4.0 ℃ 、101.33 kPa 条件下， 以93%的产率得到lidocainium hydrocarbonate
  参考文献：
  名称：

  [DE] AMMONIUMSALZE UND AMMONIUMSALZ-MINERALSALZCLATHRATE ALS TRANSPORT- UND WIRKFORM FÜR PHARMAZEUTISCH-MEDIZINISCHE UND ALS PHASENTRANSFERMIITEL FÜR CHEMISCHE ANWENDUNGEN
  [EN] AMMONIUM SALTS AND AMMONIUM SALT/MINERAL SALT CLATHRATE COMPOUNDS FOR USE AS VEHICLE AND EFFECTIVE FORM FOR PHARMACO-MEDICAL APPLICATIONS AND FOR USE AS PHASE TRANSFER AGENTS FOR CHEMICAL APPLICATIONS
  [FR] SELS D'AMMONIUM ET CLATHRATES DE SELS D'AMMONIUM ET DE SELS MINERAUX CONSTITUANT UNE FORME DE TRANSPORT ET UNE FORME ACTIVE POUR DES APPLICATIONS MEDICO-PHARMACEUTIQUES ET DES AGENTS DE TRANSFERT DE PHASE POUR DES APPLICATIONS CHIMIQUES

  摘要：

  公开号：

  WO2006007835A3

文献信息

• CARBONIC ACID ADDUCTS
  申请人：JENCLUSTER GMBH

  公开号：US20200216384A1

  公开（公告）日：2020-07-09

  The present invention relates to a carbonic acid adduct (CAA) comprising carbonic acid, at least one amine, and optionally at least one salt, said adduct being producible by a method comprising the following steps: a) providing a solution (A) comprising dissolved CO 2 ; optionally b) dissolving a base (BA) not corresponding to the amine (AM) in the solution (A) so as to obtain the solution (A1); c) dissolving the at least one amine (AM) in the solution (A) or (A1) so as to obtain the solution (B); d) freezing the solution obtained after completion of step c); and e) storing the solution frozen in step d) at −100 to 0° C. for no longer than 4 days. The content of CO 2 in the solution that is subjected to step c) is at least 6 g/l. The invention also relates to a method for producing the carbonic acid adduct (CAA), a pharmaceutical preparation (PP) comprising the carbonic acid adduct (CAA), and methods for the production thereof and use of the carbonic acid adduct (CAA) or the pharmaceutical preparation (PP) in therapy for a range of indications.
• [DE] AMMONIUMSALZE UND AMMONIUMSALZ-MINERALSALZCLATHRATE ALS TRANSPORT- UND WIRKFORM FÜR PHARMAZEUTISCH-MEDIZINISCHE UND ALS PHASENTRANSFERMIITEL FÜR CHEMISCHE ANWENDUNGEN<br/>[EN] AMMONIUM SALTS AND AMMONIUM SALT/MINERAL SALT CLATHRATE COMPOUNDS FOR USE AS VEHICLE AND EFFECTIVE FORM FOR PHARMACO-MEDICAL APPLICATIONS AND FOR USE AS PHASE TRANSFER AGENTS FOR CHEMICAL APPLICATIONS<br/>[FR] SELS D'AMMONIUM ET CLATHRATES DE SELS D'AMMONIUM ET DE SELS MINERAUX CONSTITUANT UNE FORME DE TRANSPORT ET UNE FORME ACTIVE POUR DES APPLICATIONS MEDICO-PHARMACEUTIQUES ET DES AGENTS DE TRANSFERT DE PHASE POUR DES APPLICATIONS CHIMIQUES
  申请人：KASCH HELMUT

  公开号：WO2006007835A3

  公开（公告）日：2006-04-13