1-methyl-4-vinylpyridinium bromide | 45708-76-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-methyl-4-vinylpyridinium bromide
• 英文别名: 4-vinyl-1-methylpyridinium bromide；N-methyl-4-vinylpyridinium bromide)；4-ethenyl-1-methylpyridin-1-ium;bromide
• CAS: 45708-76-7
• 化学式: Br*C₈H₁₀N
• 分子量: 200.078
• InChiKey: IITUOFIPZOFBRF-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.84
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-methyl-4-vinylpyridinium bromide 在 sodium amalgam 作用下， 以 乙腈 为溶剂， 生成 1,2-bis(1-methyl-1,4-dihydro-4-pyridinylidene)cyclobutane
  参考文献：
  名称：

  Formation of 1,2-Bis(1-methyl-1,4-dihydro-4-pyridinylidene)cyclobutane by Dehydrogenated Intermolecular Cyclization of 4-Vinyl-1-methylpyridinyl Radical

  摘要：

  在0°C下，4-乙烯基-1-甲基吡啶溴化物通过钠汞齐在脱气乙腈中的单电子还原反应，形成了1,2-双(1-甲基-1,4-二氢-4-吡啶亚胺基)环丁烷，该化合物通过1H NMR、13C NMR及紫外-可见光吸收光谱进行了表征。

  DOI：

  10.1246/cl.2009.896
• 作为产物：
  描述：

  4-乙烯基吡啶 、 溴甲烷 以 甲醇 为溶剂， 生成 1-methyl-4-vinylpyridinium bromide
  参考文献：
  名称：

  Formation of 1,2-Bis(1-methyl-1,4-dihydro-4-pyridinylidene)cyclobutane by Dehydrogenated Intermolecular Cyclization of 4-Vinyl-1-methylpyridinyl Radical

  摘要：

  在0°C下，4-乙烯基-1-甲基吡啶溴化物通过钠汞齐在脱气乙腈中的单电子还原反应，形成了1,2-双(1-甲基-1,4-二氢-4-吡啶亚胺基)环丁烷，该化合物通过1H NMR、13C NMR及紫外-可见光吸收光谱进行了表征。

  DOI：

  10.1246/cl.2009.896

文献信息

• [EN] MACROMOLECULAR PRODRUGS FOR HARD TISSUE AND METHODS OF USE THEREOF<br/>[FR] PROMÉDICAMENTS MACROMOLÉCULAIRES POUR TISSU DUR ET LEURS PROCÉDÉS D'UTILISATION
  申请人：NEW YORK SOC RUPTURED & CRIPPLED MAINTAINING HOSPITAL FOR SPECIAL SURGERY

  公开号：WO2014036548A1

  公开（公告）日：2014-03-06

  Compositions for intravenous administration and methods for treating bone diseases, disorders, and fractures comprising macromolecular prodrugs of hydrophobic bone anabolic agents are provided. Specifically, novel macromolecular amphiphilic prodrugs wherein at least three molecules of simvastatin are conjugated to polyethylene glycol, which spontaneously form micelles in aqueous solutions are provided.

  提供用于静脉给药的组成物以及包括疏水性骨骼合成剂的巨分子前药治疗骨骼疾病、紊乱和骨折的方法。具体而言，提供新颖的巨分子两亲性前药，其中至少三分子辛伐他汀与聚乙二醇共轭，它们在水溶液中自发形成胶束。
• RADIATION ENHANCED MACROMOLECULAR DELIVERY OF THERAPEUTIC AGENTS FOR CHEMOTHERAPY
  申请人：UNIVERSITY OF UTAH RESEARCH FOUNDATION

  公开号：US20160166693A1

  公开（公告）日：2016-06-16

  Described herein are anti-cancer compounds composed of a macromolecule comprising (1) at least one anti-cancer agent directly or indirectly bonded to the macromolecule and (2) at least one high Z element directly or indirectly bonded to the macromolecule that is capable of producing Auger electrons upon exposure to X-ray energy. When the compounds are exposed to low energy X-ray (e.g., kilo electron volts KeV) Auger electrons are produced by the high Z elements present in the compound. Because lower energy is required when compared to typical radiotherapy, which uses therapeutic X-ray energy in the million electron volt range (MeV), the subject experiences lower collateral damage when compared to radiation therapy. Additionally, the presence of the anti-cancer agent provides a second mechanism for killing cancer cells. Methods for making and using the anti-cancer compounds are also described herein.

  本文描述了一种抗癌化合物，由包括（1）至少一种直接或间接与大分子结合的抗癌药物和（2）至少一种直接或间接与大分子结合的高Z元素组成，该高Z元素在暴露于X射线能量时能够产生奥古尔电子。当这些化合物暴露于低能量X射线（例如，千电子伏特KeV）时，化合物中存在的高Z元素会产生奥古尔电子。与使用百万电子伏特范围内的治疗性X射线能量（MeV）的典型放射疗法相比，所需的能量更低，因此受试者在与放射疗法相比时经历较低的附带损伤。此外，抗癌药物的存在提供了杀死癌细胞的第二机制。本文还描述了制备和使用抗癌化合物的方法。
• [EN] MACROMOLECULAR DELIVERY SYSTEMS FOR NON-INVASIVE IMAGING, EVALUATION AND TREATMENT OF ARTHRITIS AND OTHER INFLAMMATORY DISEASES<br/>[FR] SYSTEMES D'ADMINISTRATION MACROMOLECULAIRES DESTINES A L'IMAGERIE, A L'EVALUATION ET AU TRAITEMENT NON INVASIFS DE L'ARTHRITE ET D'AUTRES MALADIES INFLAMMATOIRES
  申请人：UNIV UTAH RES FOUND

  公开号：WO2005097073A1

  公开（公告）日：2005-10-20

  This invention relates to biotechnology, more particularly, to water-soluble polymeric delivery systems for the imaging, evaluation and/or treatment of rheumatoid arthritis and other inflammatory diseases. Using modern MR imaging techniques, the specific accumulation of macromolecules in arthritic joints in adjuvant-induced arthritis in rats is demonstrated. The strong correlation between the uptake and retention of the MR contrast agent labeled polymer with histopathological features of inflammation and local tissue damage demonstrates the practical applications of the macromolecular delivery system of the invention.

  本发明涉及生物技术，更具体地说，涉及用于成像、评估和/或治疗类风湿性关节炎和其他炎症性疾病的水溶性高分子递送系统。利用现代磁共振成像技术，证明了大分子在大鼠佐剂诱导性关节炎中的关节特异性积累。MR对比剂标记的聚合物的摄取和保留与炎症和局部组织损伤的组织病理学特征之间的强相关性证明了本发明的高分子递送系统的实际应用。
• Microbial adsorbent and microbial sensor using the same
  申请人：KAO CORPORATION

  公开号：EP0360276A2

  公开（公告）日：1990-03-28

  A microbial sensor, which comprises a container packed with a microbial adsorbent on which an aerobic microorganism is immobilized and an electrochemical device whereby a substance consumed or produced under the effects of said microorganism is determined, is disclosed. The microbial sensor of the present invention makes it possible to rapidly and readily determine, for example, BOD at a high accuracy.

  本发明公开了一种微生物传感器，它包括一个装有微生物吸附剂的容器，容器上固定有好氧微生物，还包括一个电化学装置，用于测定在所述微生物作用下消耗或产生的物质。本发明的微生物传感器可以快速、方便、高精度地测定生化需氧量等。
• Process for the treatment of oily residues coming from the oil industry
  申请人：ENI S.p.A.

  公开号：EP2336268A1

  公开（公告）日：2011-06-22

  Process for the treatment of oily residues coming from the oil industry comprising: - subjecting said oily residues to extraction by mixing with at least one organic solvent obtaining an oily residues-solvent mixture; - subjecting said oily residues-solvent mixture to separation to obtain an oily phase, a solid phase and an aqueous phase.

  处理石油工业油性残留物的工艺，包括 - 将油性残留物与至少一种有机溶剂混合进行萃取，得到油性残留物-溶剂混合物； - 将所述油性残留物-溶剂混合物进行分离，以获得油相、固相和水相。