4,6-dichloro-2-methyl-5-(2-imidazolin-2-yl)-aminopyrimidine | 352457-35-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4,6-dichloro-2-methyl-5-(2-imidazolin-2-yl)-aminopyrimidine
• 英文别名: 4,6-Dichloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2-methylpyrimidin-5-amine；4,6-dichloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2-methylpyrimidin-5-amine
• CAS: 352457-35-3
• 化学式: C₈H₉Cl₂N₅
• 分子量: 246.099
• InChiKey: FRCNQZFYEPYVDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  62.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  mono-Moxonidine oxalate 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 1.0h， 以94%的产率得到莫索尼啶
  参考文献：
  名称：

  The use of moxonidine salts for purification of moxonidine

  摘要：

  公开号：

  EP1894927B1

文献信息

• Process for the preparation of moxonidine
  申请人：Hetero Research Foundation

  公开号：EP2586779A1

  公开（公告）日：2013-05-01

  The present invention provides an improved process for the preparation of 4,6-dichloro-2-methyl-5-(1-acetyl-2-imidazolin-2-yl)aminopyrimidine. The present invention also provides an improved process for the preparation of moxonidine. The present invention further provides a process for the purification of moxonidine.

  本发明提供了一种改进的制备4,6-二氯-2-甲基-5-(1-乙酰-2-咪唑啉-2-基)氨基嘧啶的方法。本发明还提供了一种改进的制备莫西地辛的方法。本发明进一步提供了一种莫西地辛的纯化方法。
• [DE] MOXONIDINSYNTHESE MIT HILFE ORGANISCHER BASEN<br/>[EN] MOXONIDINE SYNTHESIS WITH THE AID OF ORGANIC BASES<br/>[FR] SYNTHÈSE DE MOXONIDINE À L'AIDE DE BASES ORGANIQUES
  申请人：WOERWAG PHARMA GMBH & CO KG

  公开号：WO2014037391A1

  公开（公告）日：2014-03-13

  Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von Moxonidin sowie allgemein von Verbindungen mit nachstehender Strukturformel (I) wobei R ein aliphatischer und/oder aromatischer Restbedeutet. Für die Herstellung wird 4,6-Dichloro-2-methyl-5-(1-acetyl-2-imidazolin-2-yl)-amino-pyrimidin mit wenigstens einer organischen Base in einem Alkohol, vorzugsweise Methanol,oder in einem alkoholhaltigen, vorzugsweise methanolhaltigen, Lösungsmittelgemisch zur Reaktion gebracht wird.

  这项发明涉及一种制备莫索地平及具有以下结构式（I）的化合物的方法，其中R表示脂肪族和/或芳香族基团。制备方法是将4,6-二氯-2-甲基-5-(1-乙酰基-2-咪唑啉-2-基)-氨基嘧啶与至少一种有机碱在醇中，优选为甲醇，或在含醇，优选为含甲醇的溶剂混合物中反应。
• SELF-CROSSLINKABLE POLYHYDROXY POLYURETHANE RESIN, RESINACEOUS MATERIAL THAT CONTAINS THE RESIN, PROCESS FOR PRODUCTION OF THE RESIN, AND IMITATION LEATHER, SURFACING MATERIAL AND WEATHERSTRIP MATERIAL, USING THE RESIN
  申请人：Dainichiseika Color & Chemicals Mfg. Co., Ltd.

  公开号：EP2586814A1

  公开（公告）日：2013-05-01

  Provided are a self-crosslinking polyhydroxy polyurethane resin derived from a reaction of a 5-membered cyclic carbonate compound and an amine compound and having masked isocyanate groups in its structure; a process for producing the resin; an imitation leather composed of a base fabric and a resin composition composed of the resin as its principal component and impregnated in or laminated on the base fabric; a skin material made of a thermoplastic polyolefin resin, said skin material including a thermoplastic polyolefin resin sheet and a top coat layer formed directly or via a primer layer on the sheet, wherein the top coat layer has been formed with a resin composition composed of the resin as its principal component; and a weather strip material composed, as its principal components, of the resin and a specific diorganopolysiloxane and/or a silicone oil.

  本发明提供了一种自交联聚羟基聚氨酯树脂，该树脂由 5 元环状碳酸酯化合物和胺化合物反应而得，其结构中具有掩蔽的异氰酸酯基团；一种生产该树脂的工艺；一种由基布和以该树脂为主要成分并浸渍在基布中或层压在基布上的树脂组合物组成的仿皮革；一种由热塑性聚烯烃树脂制成的表皮材料，所述表皮材料包括热塑性聚烯烃树脂薄片和直接或通过薄片上的底漆层形成的面漆层，其中面漆层是用以该树脂为主要成分的树脂组合物形成的；以及一种耐候带材料，其主要成分为该树脂和特定的二异聚硅氧烷和/或硅油。
• SELF-CROSSLINKING POLYSILOXANE-MODIFIED POLYHYDROXY POLYURETHANE RESIN, RESIN MATERIAL CONTAINING SAME, METHOD FOR PRODUCING SAME, ARTIFICIAL LEATHER COMPRISING SAME, AND THERMOPLASTIC POLYOLEFIN SKIN MATERIAL COMPRISING SAME
  申请人：Dainichiseika Color & Chemicals Mfg. Co., Ltd.

  公开号：EP2610276A1

  公开（公告）日：2013-07-03

  Provided are a self-crosslinking polysiloxane-modified polyhydroxy polyurethane resin derived from a reaction of a 5-membered cyclic carbonate polysiloxane compound represented by the following formula (1) and an amine compound and having polysiloxane segments and masked isocyanate groups in its structure: wherein A means and its production process. The present invention can provide a polyhydroxy polyurethane resin, the development of applications of which has not moved ahead in the prior art, as a novel self-crosslinking polyhydroxy polyurethane resin that enables to provide products excellent in lubricity, abrasion resistance, chemical resistance, non-tackiness, heat resistance and the like, is useful from the viewpoint of the reduction of warming gas, and is responsive to the environment.

  本发明提供了一种自交联聚硅氧烷改性聚羟基聚氨酯树脂，它由下式（1）表示的 5 元环碳酸酯聚硅氧烷化合物和胺化合物反应生成，其结构中具有聚硅氧烷段和掩蔽的异氰酸酯基团： 其中 A 表示 及其生产工艺。本发明可提供一种聚羟基聚氨酯树脂，其应用的开发在现有技术中尚未取得进展，本发明作为一种新型自交联聚羟基聚氨酯树脂，可提供润滑性、耐磨性、耐化学性、无粘性、耐热性等性能优异的产品，从减少变暖气体的角度来看是有用的，并且对环境反应灵敏。
• Novel purification process of moxonidine
  申请人：CHEMAGIS LTD.

  公开号：EP1873152B1

  公开（公告）日：2008-10-15