palmitoyl-(S)-ornithine | 59012-45-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: palmitoyl-(S)-ornithine
• 英文别名: Palmitoylornithine；(2S)-2-amino-5-(hexadecanoylamino)pentanoic acid
• CAS: 59012-45-2
• 化学式: C₂₁H₄₂N₂O₃
• 分子量: 370.576
• InChiKey: WBINZUXJGSJGPL-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  棕榈酸 在 magnesium sulfate 、 对甲苯磺酸 、 三乙胺 作用下， 以 1,4-二氧六环 、 水 、 xylene 为溶剂， 反应 9.0h， 生成 palmitoyl-(S)-ornithine
  参考文献：
  名称：

  Higher N-acyl-L-amino acid derivatives

  摘要：

  A preparative method is proposed for obtaining higher N-acylamino acids by reaction of free amino acids with fatty acid nitrophenyl esters. It was shown that these acids can transport positive ions through a liquid lipophilic medium. A direct method is proposed for obtaining fatty acid 4-nitrophenyl esters by boiling 4-nitrophenol and the fatty acid in xylene in a Soxhlet apparatus in the presence of an acid catalyst.

  DOI：

  10.1007/bf00958844

文献信息

• GALACTOSE CLUSTER-PHARMACOKINETIC MODULATOR TARGETING MOIETY FOR siRNA
  申请人：Hadwiger Philipp

  公开号：US20120157509A1

  公开（公告）日：2012-06-21

  The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co-targeted delivery polymers.

  本发明涉及用于靶向递送RNA干扰（RNAi）多核苷酸至体内细胞的组合物。与单独的靶向配体相比，药代动力学调节剂改善了体内靶向。靶向配体-药代动力学调节剂靶向基团靶向的RNAi多核苷酸可以单独或与共靶向递送聚合物一起在体内给予。
• Stereochemical studies in crystal nucleation. Oriented crystal growth of glycine at interfaces covered with Langmuir and Langmuir-Blodgett films of resolved .alpha.-amino acids
  作者：E. Meir Landau、S. Grayer Wolf、M. Levanon、L. Leiserowitz、M. Lahav、J. Sagiv

  DOI：10.1021/ja00186a044

  日期：1989.2
• Higher N-acyl-L-amino acid derivatives
  作者：K. A. Kochetkov、Zh. S. Urmambetova、V. M. Belikov、Z. B. Bakasova

  DOI：10.1007/bf00958844

  日期：1990.11

  A preparative method is proposed for obtaining higher N-acylamino acids by reaction of free amino acids with fatty acid nitrophenyl esters. It was shown that these acids can transport positive ions through a liquid lipophilic medium. A direct method is proposed for obtaining fatty acid 4-nitrophenyl esters by boiling 4-nitrophenol and the fatty acid in xylene in a Soxhlet apparatus in the presence of an acid catalyst.