methyl 2-hydroxyamino-2,3-dimethylbutanoate | 79751-33-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 2-hydroxyamino-2,3-dimethylbutanoate
• 英文别名: 2-(Hydroxyamino)-2,3-dimethylbutansaeure-methylester；Methyl 2-(hydroxyamino)-2,3-dimethylbutanoate；methyl 2-(hydroxyamino)-2,3-dimethylbutanoate
• CAS: 79751-33-0
• 化学式: C₇H₁₅NO₃
• 分子量: 161.201
• InChiKey: ARNYKOXXKSBTEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 2-hydroxyamino-2,3-dimethylbutanoate 在 potassium tert-butylate 、 sodium hydride 、 碳酸氢钠 作用下， 以 水 、 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 4-Hydroxy-5-isopropyl-1-methoxymethoxy-5-methyl-3-(2,4,6-trimethyl-phenyl)-1,5-dihydro-pyrrol-2-one
  参考文献：
  名称：

  Synthesis and insecticidal activity of novel N-oxydihydropyrroles: 4-hydroxy-3-mesityl-1-methoxymethoxy derivatives with various substituents at the 5-position

  摘要：

  This paper reports the synthesis and insecticidal activity of a series of novel 4-hydroxy-3-mesityl-1-methoxymethoxy-1,5-dihydro-2H-pyrrol-2-one derivatives, in which the substituents at the 5-position were varied with a number of alkyl and spirocycloalkyl groups. Investigation of the structure-activity relationships revealed that small alkyl and spirocyclohexyl groups had a favorable effect on the insecticidal activity of these agents against Myzus persicae. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00474-1
• 作为产物：
  描述：

  2-(Benzylidenamino)-2,3-dimethylbutansaeure-methylester-N-oxid 在 盐酸羟胺 作用下， 以 乙醇 为溶剂， 反应 0.5h， 以57%的产率得到methyl 2-hydroxyamino-2,3-dimethylbutanoate
  参考文献：
  名称：

  Lau, Hans-Hermann; Schoellkopf, Ulrich, Liebigs Annalen der Chemie, 1981, # 8, p. 1378 - 1387

  摘要：

  DOI：

文献信息

• Synthesis and insecticidal activity of novel N-oxydihydropyrroles: 4-hydroxy-3-mesityl-1-methoxymethoxy derivatives with various substituents at the 5-position
  作者：Mitsuru Ito、Hideshi Okui、Harumi Nakagawa、Shigeru Mio、Ayako Kinoshita、Takashi Obayashi、Takako Miura、Junko Nagai、Shinji Yokoi、Reiji Ichinose、Keiji Tanaka、Seiichiro Kodama、Toshiaki Iwasaki、Takaaki Miyake、Miho Takashio、Jun Iwabuchi

  DOI：10.1016/s0968-0896(02)00474-1

  日期：2003.3

  This paper reports the synthesis and insecticidal activity of a series of novel 4-hydroxy-3-mesityl-1-methoxymethoxy-1,5-dihydro-2H-pyrrol-2-one derivatives, in which the substituents at the 5-position were varied with a number of alkyl and spirocycloalkyl groups. Investigation of the structure-activity relationships revealed that small alkyl and spirocyclohexyl groups had a favorable effect on the insecticidal activity of these agents against Myzus persicae. (C) 2002 Elsevier Science Ltd. All rights reserved.
• Lau, Hans-Hermann; Schoellkopf, Ulrich, Liebigs Annalen der Chemie, 1981, # 8, p. 1378 - 1387
  作者：Lau, Hans-Hermann、Schoellkopf, Ulrich

  DOI：——

  日期：——