ethyl 4-[(3-aminopyridin-2-yl)amino]-N-(3-oxospiro[3.5]non-1-en-1-yl)-L-phenylalaninate | 1031337-88-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 4-[(3-aminopyridin-2-yl)amino]-N-(3-oxospiro[3.5]non-1-en-1-yl)-L-phenylalaninate
• 英文别名: ethyl (2S)-3-[4-[(3-aminopyridin-2-yl)amino]phenyl]-2-[(3-oxospiro[3.5]non-1-en-1-yl)amino]propanoate
• CAS: 1031337-88-8
• 化学式: C₂₅H₃₀N₄O₃
• 分子量: 434.538
• InChiKey: KDSNCDXKJPKVSG-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  ethyl 4-[(3-aminopyridin-2-yl)amino]-N-(3-oxospiro[3.5]non-1-en-1-yl)-L-phenylalaninate 、 环丙乙酸 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 ethyl (S)-3-(4-((3-(2-cyclopropylacetamido)pyridin-2-yl)amino)phenyl)-2-((3-oxospiro[3.5]non-1-en-1-yl)amino)propanoate
  参考文献：
  名称：

  Imidazopyridines as VLA-4 integrin antagonists

  摘要：

  We describe a novel series of imidazopyridine substituted phenylalanines which are potent VLA-4 antagonists. A wide variety of substituents are tolerated as replacements for the pendant 3-pyridyl ring. A clear structure-activity relationship was identified around the substitution of the 3-amino-cyclobut-2-enone portion of the molecule. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.05.075
• 作为产物：
  描述：

  ethyl 4-[(3-nitropyridin-2-yl)amino]-N-(3-oxospiro[3.5]non-1-en-1-yl)-L-phenylalaninate 在 Pd/C 、 氢气 作用下， 以 乙醇 为溶剂， 以100%的产率得到ethyl 4-[(3-aminopyridin-2-yl)amino]-N-(3-oxospiro[3.5]non-1-en-1-yl)-L-phenylalaninate
  参考文献：
  名称：

  Imidazopyridines as VLA-4 integrin antagonists

  摘要：

  We describe a novel series of imidazopyridine substituted phenylalanines which are potent VLA-4 antagonists. A wide variety of substituents are tolerated as replacements for the pendant 3-pyridyl ring. A clear structure-activity relationship was identified around the substitution of the 3-amino-cyclobut-2-enone portion of the molecule. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.05.075

文献信息

• WO2008/64830
  申请人：——

  公开号：——

  公开（公告）日：——
• [EN] BICYCLIC AND HETEROBICYCLIC DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR PHARMACEUTICAL USES<br/>[FR] DÉRIVÉS BICYCLIQUES ET HÉTÉROBICYCLIQUES, LEURS PROCÉDÉS DE FABRICATION ET LEURS UTILISATIONS PHARMACEUTIQUES
  申请人：UCB PHARMA SA

  公开号：WO2008064830A1

  公开（公告）日：2008-06-05

  [EN] The present invention concerns bicyclic and heterobicyclic derivatives of formula I, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
  [FR] La présente invention concerne des dérivés bicycliques et hétérobicycliques de formule I, leurs procédés de fabrication, des compositions pharmaceutiques les contenant et leur utilisation comme produits pharmaceutiques.
• Imidazopyridines as VLA-4 integrin antagonists
  作者：David J. Phillips、Richard J. Davenport、Thierry A. Demaude、Fiona P. Galleway、Mark W. Jones、Laurent Knerr、Benjamin G. Perry、Andrew J. Ratcliffe

  DOI：10.1016/j.bmcl.2008.05.075

  日期：2008.7

  We describe a novel series of imidazopyridine substituted phenylalanines which are potent VLA-4 antagonists. A wide variety of substituents are tolerated as replacements for the pendant 3-pyridyl ring. A clear structure-activity relationship was identified around the substitution of the 3-amino-cyclobut-2-enone portion of the molecule. (c) 2008 Elsevier Ltd. All rights reserved.