2-({3,5-bis[N-(2-carboxyphenyl)carbamoyl]phenyl}carbonylamino)benzoic acid | 154751-42-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-({3,5-bis[N-(2-carboxyphenyl)carbamoyl]phenyl}carbonylamino)benzoic acid
• 英文别名: 2-[[[3,5-bis[N-(2-carboxyphenyl)-C-hydroxycarbonimidoyl]phenyl]-hydroxymethylidene]amino]benzoic acid
• CAS: 154751-42-5
• 化学式: C₃₀H₂₁N₃O₉
• 分子量: 567.511
• InChiKey: GADVSQGYCIXBNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  42
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  199
• 氢给体数：
  6
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  1,3,5-苯三甲酰氯 、 邻氨基苯甲酸 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 以88%的产率得到2-({3,5-bis[N-(2-carboxyphenyl)carbamoyl]phenyl}carbonylamino)benzoic acid
  参考文献：
  名称：

  A family of simple benzene 1,3,5-tricarboxamide (BTA) aromatic carboxylic acid hydrogels

  摘要：

  我们介绍了苯 1,3,5-三甲酰胺（BTA）芳香族羧酸衍生物水凝胶形成系列的特性。通过使用 pH 触发器，这里介绍的简单易合成的化合物在低浓度下就能稳定地形成凝胶。

  DOI：

  10.1039/c2cc37428e

文献信息

• Benzene tricarboxylic acid derivatives as insulin receptor activators
  申请人：——

  公开号：US20020103183A1

  公开（公告）日：2002-08-01

  Compounds of Formula I, and pharmaceutical compositions containing these compounds, activate the insulin receptor kinase, which leads to an increased sensitivity to insulin and an increase in glucose uptake, and are therefore useful for the treatment of animals, especially humans, with hyperglycemia, especially for the treatment of type 2 diabetes. Processes for preparation of the compounds, and their use in assays, are also disclosed.

  公式I的化合物及含有这些化合物的制药组合物，可以激活胰岛素受体激酶，从而提高对胰岛素的敏感性和葡萄糖摄取量，因此可用于治疗动物，尤其是人类的高血糖，特别是用于治疗2型糖尿病。还公开了制备这些化合物的过程以及它们在测定中的应用。
• BENZENE TRICARBOXYLIC ACID AMIDES AS INSULIN RECEPTOR ACTIVATORS
  申请人：Telik, Inc.

  公开号：EP1315695A2

  公开（公告）日：2003-06-04
• US6600069B2
  申请人：——

  公开号：US6600069B2

  公开（公告）日：2003-07-29
• [EN] BENZENE TRICARBOXYLIC ACID DERIVATIVES AS INSULIN RECEPTOR ACTIVATORS<br/>[FR] ACTIVATEURS DES RÉCEPTEURS DE L'INSULINE À BASE DE DÉRIVÉS D'ACIDE TRICARBOXYLIQUE DU BENZÈNE
  申请人：TELIK INC

  公开号：WO2002020464A2

  公开（公告）日：2002-03-14

  The present invention relates to trimesic acid amides, pharmaceutical compositions comprising said compounds, uses of said compounds and compositions, and processes for their preparation. Specifically, this invention relates to means to enhance insulin-dependent glucose uptake. More specifically, the invention concerns compounds and pharmaceutical compositions that active the insulin receptor kinase, which leads to an increased sensitivity to insulin and an increase in glucose uptake, as well as processes for preparation of the compounds. As such, the invention also concerns methods or uses of the compounds for the treatment of animals with hyperglycemia, especially for the treatment of type 2 diabetes.
• A family of simple benzene 1,3,5-tricarboxamide (BTA) aromatic carboxylic acid hydrogels
  作者：Richard C. T. Howe、Adam P. Smalley、Alexander P. M. Guttenplan、Matthew W. R. Doggett、Mark D. Eddleston、Jin Chong Tan、Gareth O. Lloyd

  DOI：10.1039/c2cc37428e

  日期：——

  We present the characterisation of a hydrogel forming family of benzene 1,3,5-tricarboxamide (BTA) aromatic carboxylic acid derivatives. The simple, easy to synthesise compounds presented here exhibit consistent gel formation at low concentrations through the use of a pH trigger.

  我们介绍了苯 1,3,5-三甲酰胺（BTA）芳香族羧酸衍生物水凝胶形成系列的特性。通过使用 pH 触发器，这里介绍的简单易合成的化合物在低浓度下就能稳定地形成凝胶。