N-((4-formylphenyl)sulfonyl)acetamide | 722492-55-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-((4-formylphenyl)sulfonyl)acetamide
• 英文别名: N-acetyl-4-formyl-benzenesulfonamide；acetyl-(4-formyl-benzenesulfonyl)-amine；Acetyl-(4-formyl-benzolsulfonyl)-amin；Acetamide, N-[(4-formylphenyl)sulfonyl]-；N-(4-formylphenyl)sulfonylacetamide
• CAS: 722492-55-9
• 化学式: C₉H₉NO₄S
• 分子量: 227.241
• InChiKey: SPGVYJJISCFDBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  88.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-((4-formylphenyl)sulfonyl)acetamide 在 羟胺 作用下， 生成 acetyl-(4-aminomethyl-benzenesulfonyl)-amine
  参考文献：
  名称：

  Ueno, Takeda Kenkyusho Nenpo, 1954, vol. 13, p. 31

  摘要：

  DOI：
• 作为产物：
  描述：

  [4-(acetylsulfamoyl)phenyl]methanediyl diacetate 在 4-二甲氨基吡啶 、 硫酸 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 3.0h， 生成 N-((4-formylphenyl)sulfonyl)acetamide
  参考文献：
  名称：

  [EN] SUBSTITUTED TRICYCLIC COMPOUNDS WITH ACTIVITY TOWARDS EP1 RECEPTORS
  [FR] COMPOSÉS TRICYCLIQUES SUBSTITUÉS POSSÉDANT UNE ACTIVITÉ CONTRE LES RÉCEPTEURS EP1

  摘要：

  公开号：

  WO2013149996A9

文献信息

• Compositions for repelling crawling insects
  申请人：——

  公开号：US20020094993A1

  公开（公告）日：2002-07-18

  The present invention relates to novel compositions, comprising a repellent and an additive, where the additive is selected from the group consisting of phenol, benzaldehyde, benzoic acid or derivatives thereof and is present in a ratio of from 10:100 to 200:100% by weight to the repellent, and to their use for repelling crawling harmful insects, in particular ants or cockroaches.

  本发明涉及新型组合物，包括一种驱虫剂和一种添加剂，其中所述添加剂选自苯酚、苯甲醛、苯甲酸或其衍生物组成的群体，并以10:100至200:100％重量的比例存在于驱虫剂中，以及其用于驱赶爬行有害昆虫，特别是蚂蚁或蟑螂。
• 2,3-Diarylpropenoic acids as selective non-steroidal inhibitors of type-5 17β-hydroxysteroid dehydrogenase (AKR1C3)
  作者：Martin Gazvoda、Nataša Beranič、Samo Turk、Bojan Burja、Marijan Kočevar、Tea Lanišnik Rižner、Stanislav Gobec、Slovenko Polanc

  DOI：10.1016/j.ejmech.2012.12.045

  日期：2013.4

  The aldo-keto reductase AKR1C3 is an important target for the development of new drugs. Selective inhibitors of this enzyme are needed because they should not inhibit other, structurally closely related AKR1C isoforms. A comprehensive series of 2,3-diarylpropenoic acids was synthesized and evaluated for the inhibition of AKR1C1-AKR1C3. We found that the 4-methylsulfonylphenyl substituent at position 2 of these acids is required to exhibit the selective inhibition of AKR1C3. The best results were obtained for the compounds that fulfill the above requirement and possess a 4-bromophenyl, 4-methylthiophenyl, 4-methylphenyl or 4-ethylphenyl substituent at position 3 of the substituted propenoic acids (i.e., acids 28, 29, 37, and 39, respectively). These compounds represent an important step toward the development of drug candidates for a treatment of the hormone-dependent and hormone-independent forms of prostate and breast cancers. (C) 2013 Elsevier Masson SAS. All rights reserved.
• Peretazhko,M.Z.; Pel'kis,P.S., Journal of general chemistry of the USSR, 1964, vol. 34, p. 3527 - 3529
  作者：Peretazhko,M.Z.、Pel'kis,P.S.

  DOI：——

  日期：——